6m4c - Revision history

OCA at 15:14, 29 November 2023

2023-11-29T15:14:55Z

←Older revision		Revision as of 15:14, 29 November 2023
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	<StructureSection load='6m4c' size='340' side='right'caption='[[6m4c]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6m4c' size='340' side='right'caption='[[6m4c]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6m4c]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Canal Canal~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M4C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6M4C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6m4c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans_SC5314 Candida albicans SC5314]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M4C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M4C FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~orf19.92~~, ~~CAALFM_C600910CA (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=237561 CANAL])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m4c OCA], [~~http~~://pdbe.org/6m4c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6m4c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6m4c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6m4c ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m4c OCA], [https://pdbe.org/6m4c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m4c RCSB], [https://www.ebi.ac.uk/pdbsum/6m4c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m4c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A1D8PPH3_CANAL A0A1D8PPH3_CANAL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canal~~]]	+	[[Category: Candida albicans SC5314]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao~~, Y G~~]]	+	[[Category: Gao YG]]
-	[[Category: Loh~~, Z Y~~]]	+	[[Category: Loh ZY]]
-	[[Category: Miao, Y]]	+	[[Category: Miao Y]]
-	[[Category: Xie, Y]]	+	[[Category: Xie Y]]
-	~~[[Category: Actin]]~~	+
-	~~[[Category: Cytosolic protein]]~~	+
-	~~[[Category: Nucleation promoting factor]]~~	+
-	~~[[Category: Polarisome~~]]	+

OCA at 09:50, 9 September 2020

2020-09-09T09:50:30Z

←Older revision		Revision as of 09:50, 9 September 2020
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	==C. albicans actin interacting protein Aip5==		==C. albicans actin interacting protein Aip5==
-	<StructureSection load='6m4c' size='340' side='right'caption='[[6m4c]]' scene=''>	+	<StructureSection load='6m4c' size='340' side='right'caption='[[6m4c]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M4C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M4C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6m4c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M4C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M4C FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m4c OCA], [http://pdbe.org/6m4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m4c RCSB], [http://www.ebi.ac.uk/pdbsum/6m4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m4c ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">orf19.92, CAALFM_C600910CA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m4c OCA], [http://pdbe.org/6m4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m4c RCSB], [http://www.ebi.ac.uk/pdbsum/6m4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m4c ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Candida albicans is a dimorphic fungus that converts from a yeast form to a hyphae form during infection. This switch requires the formation of an actin cable to coordinate polarized cell growth. It's known that nucleation of this cable requires a multiprotein complex localized at the tip called the polarisome, but the mechanisms underpinning this process were unclear. Here, we found that C. albicans Aip5, a homolog of polarisome component ScAip5 in S. cerevisiae that nucleates actin polymerization and synergizes with the formin ScBni1, regulates actin assembly and hyphae growth synergistically with other polarisome proteins Bni1, Bud6, and Spa2. The C-terminus of Aip5 binds directly to G-actin, Bni1 and the C-terminal of Bud6, which form the core of the nucleation complex to polymerize F-actin. Based on insights from structural biology and molecular dynamic simulations, we propose a possible complex conformation of the actin nucleation core, which provides cooperative positioning and supports the synergistic actin nucleation activity of a tri-protein complex Bni1-Bud6-Aip5. Together with known interactions of Bni1 with Bud6 and Aip5 in S. cerevisiae, our findings unravel molecular mechanisms of C. albicans by which the tri-protein complex coordinates the actin nucleation in actin cable assembly and hyphal growth, which is likely a conserved mechanism in different filamentous fungi and yeast.
		+
		+	Orchestrated actin nucleation by the Candida albicans polarisome complex enables filamentous growth.,Xie Y, Loh ZY, Xue J, Zhou F, Sun J, Qiao Z, Jin S, Deng Y, Li H, Wang Y, Lu L, Gao YG, Miao Y J Biol Chem. 2020 Aug 26. pii: RA120.013890. doi: 10.1074/jbc.RA120.013890. PMID:32848016<ref>PMID:32848016</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6m4c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Canal]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gao YG]]	+	[[Category: Gao, Y G]]
-	[[Category: Loh ZY]]	+	[[Category: Loh, Z Y]]
-	[[Category: Miao Y]]	+	[[Category: Miao, Y]]
-	[[Category: Xie Y]]	+	[[Category: Xie, Y]]
		+	[[Category: Actin]]
		+	[[Category: Cytosolic protein]]
		+	[[Category: Nucleation promoting factor]]
		+	[[Category: Polarisome]]

OCA at 11:12, 26 August 2020

2020-08-26T11:12:05Z

←Older revision		Revision as of 11:12, 26 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6m4c is ~~ON HOLD until Paper Publication~~	+	==C. albicans actin interacting protein Aip5==
-		+	<StructureSection load='6m4c' size='340' side='right'caption='[[6m4c]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M4C OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6M4C FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6m4c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m4c OCA], [http://pdbe.org/6m4c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6m4c RCSB], [http://www.ebi.ac.uk/pdbsum/6m4c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6m4c ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gao YG]]
		+	[[Category: Loh ZY]]
		+	[[Category: Miao Y]]
		+	[[Category: Xie Y]]

OCA at 05:29, 8 April 2020

2020-04-08T05:29:08Z

←Older revision		Revision as of 05:29, 8 April 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6m4c is ON HOLD	+	The entry 6m4c is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6m4c" [edit=sysop:move=sysop]

2020-03-11T06:00:57Z

Protected "6m4c" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:00, 11 March 2020

OCA: New page: '''Unreleased structure''' The entry 6m4c is ON HOLD Authors: Description: Category: Unreleased Structures

2020-03-11T06:00:56Z

New page: '''Unreleased structure''' The entry 6m4c is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6m4c is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]