6mbx - Revision history

OCA at 06:28, 11 October 2023

2023-10-11T06:28:18Z

←Older revision		Revision as of 06:28, 11 October 2023
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	<StructureSection load='6mbx' size='340' side='right'caption='[[6mbx]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6mbx' size='340' side='right'caption='[[6mbx]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mbx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MBX OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MBX FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mbx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cucumis_melo Cucumis melo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MBX FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mbx OCA], [~~http~~://pdbe.org/6mbx PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mbx RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mbx PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mbx ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mbx OCA], [https://pdbe.org/6mbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mbx RCSB], [https://www.ebi.ac.uk/pdbsum/6mbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mbx ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PROF_CUCME PROF_CUCME]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6mbx" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6mbx" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Profilin 3D Structures\|Profilin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cucumis melo]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chruszcz, M]]	+	[[Category: Chruszcz M]]
-	[[Category: Hyduke~~, N P~~]]	+	[[Category: Hyduke NP]]
-	[[Category: Kapingidza~~, A B]]~~	+	[[Category: Kapingidza AB]]
-	~~[[Category: Allergen]]~~	+
-	~~[[Category: Food allergen]]~~	+
-	~~[[Category: Profilin~~]]	+

OCA at 05:54, 21 August 2019

2019-08-21T05:54:19Z

←Older revision		Revision as of 05:54, 21 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6mbx is ~~ON HOLD until Paper~~ Publication	+	==CRYSTAL STRUCTURE OF MUSKMELON ALLERGEN CUC M 2==
		+	<StructureSection load='6mbx' size='340' side='right'caption='[[6mbx]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6mbx]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MBX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MBX FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mbx OCA], [http://pdbe.org/6mbx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mbx RCSB], [http://www.ebi.ac.uk/pdbsum/6mbx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mbx ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Worldwide, more than one-third of the population suffers from allergies. A significant fraction of officially registered allergens originate from the profilin family of proteins. Profilins are small ubiquitous proteins which are found in plants, viruses and various eukaryotes including mammals. Although they are primarily regarded as minor allergens, profilins are important players in immunoglobulin E (IgE) cross-reactivity. However, in some populations profilins are recognized by IgE from at least 50% of patients allergic to a given allergen source. Cuc m 2.0101 is recognized by IgE in more than 80% of muskmelon-allergic patients. The recombinant isoallergen Cuc m 2.0101 was produced in significant quantities and its X-ray crystal structure was determined. In addition, a new Art v 4.0101 (mugwort profilin) structure was determined. The profilins Cuc m 2.0101 and Art v 4.0101 were compared in terms of their structure and thermal stability. Furthermore, structural similarities and IgE cross-reactivity between profilins from different sources are discussed to explain the molecular basis of various clinical syndromes involving this group of allergens. Special emphasis is placed on discussion of profilins' quaternary structures and their relation to biological function, as well as to protein allergenicity. Moreover, a potential impact of protein purification protocols on the structure of profilins is highlighted.

-	~~Authors: Kapingidza~~, A.B., ~~Hyduke~~, N~~.P.~~, ~~Chruszcz~~, M.	+	Comparative structural and thermal stability studies of Cuc m 2.0101, Art v 4.0101 and other allergenic profilins.,Kapingidza AB, Pye SE, Hyduke N, Dolamore C, Pote S, Schlachter CR, Commins SP, Kowal K, Chruszcz M Mol Immunol. 2019 Jul 18;114:19-29. doi: 10.1016/j.molimm.2019.07.004. PMID:31326654<ref>PMID:31326654</ref>

-	~~Description: CRYSTAL STRUCTURE OF MUSKMELON ALLERGEN CUC M 2~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Kapingidza, A.B~~]]	+	<div class="pdbe-citations 6mbx" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
-	[[Category: Hyduke, N.P]]	+	[[Category: Hyduke, N P]]
		+	[[Category: Kapingidza, A B]]
		+	[[Category: Allergen]]
		+	[[Category: Food allergen]]
		+	[[Category: Profilin]]

OCA at 18:23, 19 September 2018

2018-09-19T18:23:37Z

←Older revision		Revision as of 18:23, 19 September 2018
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mbx is ON HOLD	+	The entry 6mbx is ON HOLD until Paper Publication

	Authors: Kapingidza, A.B., Hyduke, N.P., Chruszcz, M.		Authors: Kapingidza, A.B., Hyduke, N.P., Chruszcz, M.

OCA: Protected "6mbx" [edit=sysop:move=sysop]

2018-09-05T08:56:31Z

Protected "6mbx" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:56, 5 September 2018

OCA: New page: '''Unreleased structure''' The entry 6mbx is ON HOLD Authors: Kapingidza, A.B., Hyduke, N.P., Chruszcz, M. Description: CRYSTAL STRUCTURE OF MUSKMELON ALLERGEN CUC M 2 [[Category: Unre...

2018-09-05T08:56:29Z

New page: '''Unreleased structure''' The entry 6mbx is ON HOLD Authors: Kapingidza, A.B., Hyduke, N.P., Chruszcz, M. Description: CRYSTAL STRUCTURE OF MUSKMELON ALLERGEN CUC M 2 [[Category: Unre...

New page

'''Unreleased structure'''

The entry 6mbx is ON HOLD

Authors: Kapingidza, A.B., Hyduke, N.P., Chruszcz, M.

Description: CRYSTAL STRUCTURE OF MUSKMELON ALLERGEN CUC M 2
[[Category: Unreleased Structures]]
[[Category: Kapingidza, A.B]]
[[Category: Chruszcz, M]]
[[Category: Hyduke, N.P]]