6mfa - Revision history

OCA at 06:30, 11 October 2023

2023-10-11T06:30:23Z

←Older revision		Revision as of 06:30, 11 October 2023
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	<StructureSection load='6mfa' size='340' side='right'caption='[[6mfa]], [[Resolution\|resolution]] 1.75Å' scene=''>		<StructureSection load='6mfa' size='340' side='right'caption='[[6mfa]], [[Resolution\|resolution]] 1.75Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mfa]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MFA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MFA FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~FN1~~, ~~FN (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.754Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfa OCA], [~~http~~://pdbe.org/6mfa PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mfa RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mfa PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfa ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfa OCA], [https://pdbe.org/6mfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mfa RCSB], [https://www.ebi.ac.uk/pdbsum/6mfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfa ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[~~http~~://omim.org/entry/601894 601894]]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>	+	[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[https://omim.org/entry/601894 601894]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>	+	[https://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
		+
		+	==See Also==
		+	*[[Fibronectin 3D structures\|Fibronectin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Briknarova, K]]	+	[[Category: Briknarova K]]
-	[[Category: Loa, S]]	+	[[Category: Loa S]]
-	[[Category: Mou~~, T C~~]]	+	[[Category: Mou TC]]
-	[[Category: Sprang~~, S R]]~~	+	[[Category: Sprang SR]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Fibronectin]]~~	+
-	~~[[Category: Fn3 domain~~]]	+

OCA at 10:55, 18 December 2019

2019-12-18T10:55:06Z

←Older revision		Revision as of 10:55, 18 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6mfa is ~~ON HOLD~~ ~~until Paper Publication~~	+	==Fragment of human fibronectin containing the 4th-7th type III domains==
-		+	<StructureSection load='6mfa' size='340' side='right'caption='[[6mfa]], [[Resolution\|resolution]] 1.75Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mfa]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MFA FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FN1, FN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mfa OCA], [http://pdbe.org/6mfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mfa RCSB], [http://www.ebi.ac.uk/pdbsum/6mfa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mfa ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2) [MIM:[http://omim.org/entry/601894 601894]]; also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life.<ref>PMID:18268355</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FINC_HUMAN FINC_HUMAN]] Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref> Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.<ref>PMID:8114919</ref> <ref>PMID:11209058</ref> <ref>PMID:15665290</ref> <ref>PMID:19379667</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Briknarova, K]]
		+	[[Category: Loa, S]]
		+	[[Category: Mou, T C]]
		+	[[Category: Sprang, S R]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Fibronectin]]
		+	[[Category: Fn3 domain]]

OCA at 06:24, 3 October 2018

2018-10-03T06:24:11Z

←Older revision		Revision as of 06:24, 3 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mfa is ON HOLD	+	The entry 6mfa is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6mfa" [edit=sysop:move=sysop]

2018-09-19T18:26:09Z

Protected "6mfa" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:26, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6mfa is ON HOLD Authors: Description: Category: Unreleased Structures

2018-09-19T18:26:08Z

New page: '''Unreleased structure''' The entry 6mfa is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mfa is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]