6mg5 - Revision history

OCA at 08:15, 24 April 2019

2019-04-24T08:15:43Z

←Older revision		Revision as of 08:15, 24 April 2019
Line 3:		Line 3:
	<StructureSection load='6mg5' size='340' side='right'caption='[[6mg5]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='6mg5' size='340' side='right'caption='[[6mg5]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mg5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mg5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG5 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ZW:7-(DIETHYLAMINO)-4-METHYL-2H-1-BENZOPYRAN-2-ONE'>6ZW</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ZW:7-(DIETHYLAMINO)-4-METHYL-2H-1-BENZOPYRAN-2-ONE'>6ZW</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg5 OCA], [http://pdbe.org/6mg5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg5 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg5 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg5 OCA], [http://pdbe.org/6mg5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg5 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg5 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In Ig light-chain (LC) amyloidosis (AL), the unique antibody LC protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. As a step toward developing treatments for AL patients with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, we introduce small-molecule kinetic stabilizers of the native dimeric structure of full-length LCs, which can slow or stop the amyloidogenicity cascade at its origin. A protease-coupled fluorescence polarization-based high-throughput screen was employed to identify small molecules that kinetically stabilize LCs. NMR and X-ray crystallographic data demonstrate that at least one structural family of hits bind at the LC-LC dimerization interface within full-length LCs, utilizing variable-domain residues that are highly conserved in most AL patients. Stopping the amyloidogenesis cascade at the beginning is a proven strategy to ameliorate postmitotic tissue degeneration.
		+
		+	Stabilization of amyloidogenic immunoglobulin light chains by small molecules.,Morgan GJ, Yan NL, Mortenson DE, Rennella E, Blundon JM, Gwin RM, Lin CY, Stanfield RL, Brown SJ, Rosen H, Spicer TP, Fernandez-Vega V, Merlini G, Kay LE, Wilson IA, Kelly JW Proc Natl Acad Sci U S A. 2019 Apr 10. pii: 1817567116. doi:, 10.1073/pnas.1817567116. PMID:30971495<ref>PMID:30971495</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6mg5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Kelly, J W]]		[[Category: Kelly, J W]]

OCA at 07:26, 10 April 2019

2019-04-10T07:26:28Z

←Older revision		Revision as of 07:26, 10 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mg5 ~~is ON HOLD until Paper Publication~~	+	==Structure of full-length human lambda-6A light chain JTO in complex with coumarin 1==
-		+	<StructureSection load='6mg5' size='340' side='right'caption='[[6mg5]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mg5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MG5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MG5 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6ZW:7-(DIETHYLAMINO)-4-METHYL-2H-1-BENZOPYRAN-2-ONE'>6ZW</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mg5 OCA], [http://pdbe.org/6mg5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mg5 RCSB], [http://www.ebi.ac.uk/pdbsum/6mg5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mg5 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kelly, J W]]
		+	[[Category: Morgan, G J]]
		+	[[Category: Mortenson, D E]]
		+	[[Category: Stanfield, R L]]
		+	[[Category: Wilson, I A]]
		+	[[Category: Yan, N L]]
		+	[[Category: Amyloidosis]]
		+	[[Category: Immune system]]
		+	[[Category: Light chain]]

OCA at 06:24, 3 October 2018

2018-10-03T06:24:45Z

←Older revision		Revision as of 06:24, 3 October 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mg5 is ON HOLD	+	The entry 6mg5 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6mg5" [edit=sysop:move=sysop]

2018-09-19T18:28:45Z

Protected "6mg5" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:28, 19 September 2018

OCA: New page: '''Unreleased structure''' The entry 6mg5 is ON HOLD Authors: Description: Category: Unreleased Structures

2018-09-19T18:28:43Z

New page: '''Unreleased structure''' The entry 6mg5 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6mg5 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]