6mjl - Revision history

OCA at 14:43, 13 March 2024

2024-03-13T14:43:25Z

←Older revision		Revision as of 14:43, 13 March 2024
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-	====	+	==Crystal structure of ChREBP NLS peptide bound to importin alpha.==
-	<StructureSection load='6mjl' size='340' side='right'caption='[[6mjl]]' scene=''>	+	<StructureSection load='6mjl' size='340' side='right'caption='[[6mjl]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mjl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MJL FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6mjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjl OCA], [~~http~~://pdbe.org/6mjl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mjl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mjl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjl ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjl OCA], [https://pdbe.org/6mjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mjl RCSB], [https://www.ebi.ac.uk/pdbsum/6mjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjl ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IMA1_MOUSE IMA1_MOUSE] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
		+
		+	==See Also==
		+	*[[Importin 3D structures\|Importin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Mus musculus]]
		+	[[Category: Jung H]]
		+	[[Category: Uyeda K]]

OCA at 06:29, 7 October 2020

2020-10-07T06:29:50Z

←Older revision		Revision as of 06:29, 7 October 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6mjl ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6mjl' size='340' side='right'caption='[[6mjl]]' scene=''>
-	~~Authors~~: ~~Jung, H~~.~~, Uyeda, K~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description: Crystal~~ structure ~~of ChREBP NLS peptide bound to importin alpha~~.	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6mjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mjl OCA], [http://pdbe.org/6mjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mjl RCSB], [http://www.ebi.ac.uk/pdbsum/6mjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mjl ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[Category: ~~Uyeda, K~~]]	+	__TOC__
-	[[Category: ~~Jung, H~~]]	+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "6mjl" [edit=sysop:move=sysop]

2018-10-03T06:26:15Z

Protected "6mjl" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:26, 3 October 2018

OCA: New page: '''Unreleased structure''' The entry 6mjl is ON HOLD until Paper Publication Authors: Jung, H., Uyeda, K. Description: Crystal structure of ChREBP NLS peptide bound to importin alpha. ...

2018-10-03T06:26:14Z

New page: '''Unreleased structure''' The entry 6mjl is ON HOLD until Paper Publication Authors: Jung, H., Uyeda, K. Description: Crystal structure of ChREBP NLS peptide bound to importin alpha. ...

New page

'''Unreleased structure'''

The entry 6mjl is ON HOLD until Paper Publication

Authors: Jung, H., Uyeda, K.

Description: Crystal structure of ChREBP NLS peptide bound to importin alpha.
[[Category: Unreleased Structures]]
[[Category: Uyeda, K]]
[[Category: Jung, H]]