6mym - Revision history

OCA at 06:41, 11 October 2023

2023-10-11T06:41:53Z

←Older revision		Revision as of 06:41, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6mym' size='340' side='right'caption='[[6mym]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='6mym' size='340' side='right'caption='[[6mym]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6mym]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~I82a9 I82a9~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6MYM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6mym]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Philippines/2/1982(H3N2)) Influenza A virus (A/Philippines/2/1982(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MYM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.45Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HA ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=382825 I82A9])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6mym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mym OCA], [~~http~~://pdbe.org/6mym PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6mym RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6mym PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6mym ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mym OCA], [https://pdbe.org/6mym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mym RCSB], [https://www.ebi.ac.uk/pdbsum/6mym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mym ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/D8KS88_I82A9 D8KS88_I82A9]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072][SAAS:SAAS01039073] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]	+	[https://www.uniprot.org/uniprot/D8KS88_I82A9 D8KS88_I82A9] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072][SAAS:SAAS01039073] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: I82a9]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Dai YN]]
-	[[Category: Dai~~, Y N~~]]	+	[[Category: Fremont DH]]
-	[[Category: Fremont~~, D H]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Influenza hemagglutinin crystal structure]]~~	+
-	~~[[Category: Viral protein~~]]	+

OCA at 07:32, 21 May 2019

2019-05-21T07:32:42Z

←Older revision		Revision as of 07:32, 21 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6mym is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of hemagglutinin from influenza virus A/Phillipines/2/1982 (H3N2)==
-		+	<StructureSection load='6mym' size='340' side='right'caption='[[6mym]], [[Resolution\|resolution]] 2.45Å' scene=''>
-	~~Authors~~: ~~Dai~~, Y.N., ~~Fremont~~, D.H., ~~Center for Structural Genomics of Infectious Diseases (CSGID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6mym]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/I82a9 I82a9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MYM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MYM FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of hemagglutinin from influenza virus A~~/~~Phillipines~~/2/~~1982 (H3N2)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=382825 I82A9])</td></tr>
-	[[Category: Fremont, D.H]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mym OCA], [http://pdbe.org/6mym PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mym RCSB], [http://www.ebi.ac.uk/pdbsum/6mym PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mym ProSAT]</span></td></tr>
-	[[Category: ~~Center For Structural Genomics Of Infectious Diseases (~~Csgid)]]	+	</table>
-	[[Category: ~~Dai, Y.N~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/D8KS88_I82A9 D8KS88_I82A9]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[HAMAP-Rule:MF_04072][SAAS:SAAS01039073] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: I82a9]]
		+	[[Category: Large Structures]]
		+	[[Category: Structural genomic]]
		+	[[Category: Dai, Y N]]
		+	[[Category: Fremont, D H]]
		+	[[Category: Csgid]]
		+	[[Category: Influenza hemagglutinin crystal structure]]
		+	[[Category: Viral protein]]

OCA at 06:44, 26 December 2018

2018-12-26T06:44:16Z

←Older revision		Revision as of 06:44, 26 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6mym is ON HOLD	+	The entry 6mym is ON HOLD until Paper Publication

	Authors: Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID)		Authors: Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID)
Line 8:		Line 8:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Fremont, D.H]]		[[Category: Fremont, D.H]]
-	[[Category: Dai, Y.N]]
	[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]		[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
		+	[[Category: Dai, Y.N]]

OCA at 06:40, 14 November 2018

2018-11-14T06:40:03Z

←Older revision		Revision as of 06:40, 14 November 2018
Line 3:		Line 3:
	The entry 6mym is ON HOLD		The entry 6mym is ON HOLD

-	Authors: Dai, Y.N., Fremont, D.H.	+	Authors: Dai, Y.N., Fremont, D.H., Center for Structural Genomics of Infectious Diseases (CSGID)

	Description: Crystal structure of hemagglutinin from influenza virus A/Phillipines/2/1982 (H3N2)		Description: Crystal structure of hemagglutinin from influenza virus A/Phillipines/2/1982 (H3N2)
Line 9:		Line 9:
	[[Category: Fremont, D.H]]		[[Category: Fremont, D.H]]
	[[Category: Dai, Y.N]]		[[Category: Dai, Y.N]]
		+	[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]

OCA: Protected "6mym" [edit=sysop:move=sysop]

2018-11-07T10:59:47Z

Protected "6mym" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:59, 7 November 2018

OCA: New page: '''Unreleased structure''' The entry 6mym is ON HOLD Authors: Dai, Y.N., Fremont, D.H. Description: Crystal structure of hemagglutinin from influenza virus A/Phillipines/2/1982 (H3N2) ...

2018-11-07T10:59:45Z

New page: '''Unreleased structure''' The entry 6mym is ON HOLD Authors: Dai, Y.N., Fremont, D.H. Description: Crystal structure of hemagglutinin from influenza virus A/Phillipines/2/1982 (H3N2) ...

New page

'''Unreleased structure'''

The entry 6mym is ON HOLD

Authors: Dai, Y.N., Fremont, D.H.

Description: Crystal structure of hemagglutinin from influenza virus A/Phillipines/2/1982 (H3N2)
[[Category: Unreleased Structures]]
[[Category: Fremont, D.H]]
[[Category: Dai, Y.N]]