6n3p - Revision history

OCA at 06:44, 11 October 2023

2023-10-11T06:44:31Z

←Older revision		Revision as of 06:44, 11 October 2023
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	<StructureSection load='6n3p' size='340' side='right'caption='[[6n3p]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6n3p' size='340' side='right'caption='[[6n3p]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n3p]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_coli"_migula_1895 "bacillus~~ coli~~" migula 1895~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3P OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6N3P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n3p]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6N3P FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=XLN:N~3~-{(2R)-4~~-[~~(dihydroxyphosphanyl)oxy~~]-2~~-hydroxy-3,3-dimethylbutanoyl}-N-(3-{[(1Z)-pent-1-en-1-yl]sulfonyl}propyl)-beta-alaninamide'>XLN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>fabZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id=~~562~~ "~~Bacillus coli~~" ~~Migula 1895]), acpP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td~~><~~/tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=XLN:N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(3-{[(1Z)-pent-1-en-1-yl]sulfonyl}propyl)-beta-alaninamide'>XLN</scene></td></tr>
-	~~<tr id~~='~~activity'><td class~~=~~"sblockLbl"><b>Activity~~:~~</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/~~3-~~hydroxyacyl~~-[~~acyl~~-~~carrier~~-~~protein]_dehydratase~~ 3-~~hydroxyacyl~~-~~[acyl~~-~~carrier~~-~~protein] dehydratase], with EC number~~ [~~http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=4.2.~~1~~.59 4.2.~~1~~.59~~] </~~span~~></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6n3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3p OCA], [https://pdbe.org/6n3p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6n3p RCSB], [https://www.ebi.ac.uk/pdbsum/6n3p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3p ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6n3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3p OCA], [~~http~~://pdbe.org/6n3p PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6n3p RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6n3p PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3p ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~FABZ_ECO45 FABZ_ECO45]~~] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. ~~[[http~~://~~www.uniprot.org~~/~~uniprot/ACP_ECO45 ACP_ECO45]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217]~~	+	[https://www.uniprot.org/uniprot/FABZ_ECOLI FABZ_ECOLI] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.<ref>PMID:10629181</ref> <ref>PMID:7806516</ref> <ref>PMID:8910376</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
		+	*[[Acyl carrier protein 3D structures\|Acyl carrier protein 3D structures]]
	*[[Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures\|Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures]]		*[[Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures\|Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures]]
	== References ==		== References ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ coli ~~migula 1895~~]]	+	[[Category: Escherichia coli]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dodge~~, G J~~]]	+	[[Category: Dodge GJ]]
-	[[Category: Smith~~, J L]]~~	+	[[Category: Smith JL]]
-	~~[[Category: Acp]]~~	+
-	~~[[Category: Acpp]]~~	+
-	~~[[Category: Acyl carrier protein]]~~	+
-	~~[[Category: Biosynthetic protein]]~~	+
-	~~[[Category: Crosslinking]]~~	+
-	~~[[Category: Dehydratase]]~~	+
-	~~[[Category: E. coli]]~~	+
-	~~[[Category: Fa]]~~	+
-	~~[[Category: Fabz]]~~	+
-	~~[[Category: Fatty acid biosynthsis~~]]	+

OCA at 07:58, 10 April 2019

2019-04-10T07:58:07Z

←Older revision		Revision as of 07:58, 10 April 2019
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	</div>		</div>
	<div class="pdbe-citations 6n3p" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6n3p" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures\|Beta-hydroxyacyl-acyl carrier protein dehydratase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:08, 27 March 2019

2019-03-27T07:08:55Z

←Older revision		Revision as of 07:08, 27 March 2019
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	<StructureSection load='6n3p' size='340' side='right'caption='[[6n3p]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6n3p' size='340' side='right'caption='[[6n3p]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6n3p]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3P FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6n3p]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3P FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XLN:N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(3-{[(1Z)-pent-1-en-1-yl]sulfonyl}propyl)-beta-alaninamide'>XLN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XLN:N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(3-{[(1Z)-pent-1-en-1-yl]sulfonyl}propyl)-beta-alaninamide'>XLN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fabZ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), acpP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyacyl-[acyl-carrier-protein]_dehydratase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.59 4.2.1.59] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyacyl-[acyl-carrier-protein]_dehydratase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.59 4.2.1.59] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3p OCA], [http://pdbe.org/6n3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3p RCSB], [http://www.ebi.ac.uk/pdbsum/6n3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3p ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3p OCA], [http://pdbe.org/6n3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3p RCSB], [http://www.ebi.ac.uk/pdbsum/6n3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3p ProSAT]</span></td></tr>
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FABZ_ECO45 FABZ_ECO45]] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. [[http://www.uniprot.org/uniprot/ACP_ECO45 ACP_ECO45]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217]		[[http://www.uniprot.org/uniprot/FABZ_ECO45 FABZ_ECO45]] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. [[http://www.uniprot.org/uniprot/ACP_ECO45 ACP_ECO45]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Fatty acid biosynthesis in alpha- and gamma-proteobacteria requires two functionally distinct dehydratases, FabA and FabZ. Here, mechanistic cross-linking facilitates the structural characterization of a stable hexameric complex of six Escherichia coli FabZ dehydratase subunits with six AcpP acyl carrier proteins. The crystal structure sheds light on the divergent substrate selectivity of FabA and FabZ by revealing distinct architectures of the binding pocket. Molecular dynamics simulations demonstrate differential biasing of substrate orientations and conformations within the active sites of FabA and FabZ such that FabZ is preorganized to catalyze only dehydration, while FabA is primed for both dehydration and isomerization.
		+
		+	Structural and dynamical rationale for fatty acid unsaturation in Escherichia coli.,Dodge GJ, Patel A, Jaremko KL, McCammon JA, Smith JL, Burkart MD Proc Natl Acad Sci U S A. 2019 Mar 14. pii: 1818686116. doi:, 10.1073/pnas.1818686116. PMID:30872475<ref>PMID:30872475</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6n3p" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus coli migula 1895]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Dodge, G J]]		[[Category: Dodge, G J]]

OCA at 12:10, 13 March 2019

2019-03-13T12:10:04Z

←Older revision		Revision as of 12:10, 13 March 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6n3p is ~~ON HOLD until Paper Publication~~	+	==Crosslinked AcpP=FabZ complex from E. coli Type II FAS==
-		+	<StructureSection load='6n3p' size='340' side='right'caption='[[6n3p]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6n3p]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6N3P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6N3P FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=XLN:N~3~-{(2R)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-(3-{[(1Z)-pent-1-en-1-yl]sulfonyl}propyl)-beta-alaninamide'>XLN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3-hydroxyacyl-[acyl-carrier-protein]_dehydratase 3-hydroxyacyl-[acyl-carrier-protein] dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.59 4.2.1.59] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6n3p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6n3p OCA], [http://pdbe.org/6n3p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6n3p RCSB], [http://www.ebi.ac.uk/pdbsum/6n3p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6n3p ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FABZ_ECO45 FABZ_ECO45]] Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. [[http://www.uniprot.org/uniprot/ACP_ECO45 ACP_ECO45]] Carrier of the growing fatty acid chain in fatty acid biosynthesis.[HAMAP-Rule:MF_01217]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Dodge, G J]]
		+	[[Category: Smith, J L]]
		+	[[Category: Acp]]
		+	[[Category: Acpp]]
		+	[[Category: Acyl carrier protein]]
		+	[[Category: Biosynthetic protein]]
		+	[[Category: Crosslinking]]
		+	[[Category: Dehydratase]]
		+	[[Category: E. coli]]
		+	[[Category: Fa]]
		+	[[Category: Fabz]]
		+	[[Category: Fatty acid biosynthsis]]

OCA at 06:44, 26 December 2018

2018-12-26T06:44:42Z

←Older revision		Revision as of 06:44, 26 December 2018
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6n3p is ON HOLD	+	The entry 6n3p is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6n3p" [edit=sysop:move=sysop]

2018-12-02T19:13:24Z

Protected "6n3p" [edit=sysop:move=sysop]

←Older revision

Revision as of 19:13, 2 December 2018

OCA: New page: '''Unreleased structure''' The entry 6n3p is ON HOLD Authors: Description: Category: Unreleased Structures

2018-12-02T19:13:23Z

New page: '''Unreleased structure''' The entry 6n3p is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6n3p is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]