6nc8 - Revision history

OCA at 06:49, 11 October 2023

2023-10-11T06:49:20Z

←Older revision		Revision as of 06:49, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6nc8' size='340' side='right'caption='[[6nc8]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6nc8' size='340' side='right'caption='[[6nc8]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nc8]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Theab Theab~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NC8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nc8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermosipho_africanus_TCF52B Thermosipho africanus TCF52B]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NC8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.601Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murJ, mviN, THA_1814 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484019 THEAB])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nc8 OCA], [~~http~~://pdbe.org/6nc8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6nc8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6nc8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6nc8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nc8 OCA], [https://pdbe.org/6nc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nc8 RCSB], [https://www.ebi.ac.uk/pdbsum/6nc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nc8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MURJ_THEAB MURJ_THEAB]] Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.[HAMAP-Rule:MF_02078]<ref>PMID:28024149</ref>	+	[https://www.uniprot.org/uniprot/MURJ_THEAB MURJ_THEAB] Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.[HAMAP-Rule:MF_02078]<ref>PMID:28024149</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Theab~~]]	+	[[Category: Thermosipho africanus TCF52B]]
-	[[Category: Kuk~~, A C.Y~~]]	+	[[Category: Kuk ACY]]
-	[[Category: Lee, S Y]]	+	[[Category: Lee S-Y]]
-	~~[[Category: Cell wall]]~~	+
-	~~[[Category: Flippase]]~~	+
-	~~[[Category: Peptidoglycan]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Transporter~~]]	+

OCA at 09:20, 1 May 2019

2019-05-01T09:20:33Z

←Older revision		Revision as of 09:20, 1 May 2019
Line 3:		Line 3:
	<StructureSection load='6nc8' size='340' side='right'caption='[[6nc8]], [[Resolution\|resolution]] 2.60Å' scene=''>		<StructureSection load='6nc8' size='340' side='right'caption='[[6nc8]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nc8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NC8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nc8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Theab Theab]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NC8 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">murJ, mviN, THA_1814 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=484019 THEAB])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nc8 OCA], [http://pdbe.org/6nc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nc8 RCSB], [http://www.ebi.ac.uk/pdbsum/6nc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nc8 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nc8 OCA], [http://pdbe.org/6nc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nc8 RCSB], [http://www.ebi.ac.uk/pdbsum/6nc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nc8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MURJ_THEAB MURJ_THEAB]] Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.[HAMAP-Rule:MF_02078]<ref>PMID:28024149</ref>		[[http://www.uniprot.org/uniprot/MURJ_THEAB MURJ_THEAB]] Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.[HAMAP-Rule:MF_02078]<ref>PMID:28024149</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The biosynthesis of many polysaccharides, including bacterial peptidoglycan and eukaryotic N-linked glycans, requires transport of lipid-linked oligosaccharide (LLO) precursors across the membrane by specialized flippases. MurJ is the flippase for the lipid-linked peptidoglycan precursor Lipid II, a key player in bacterial cell wall synthesis, and a target of recently discovered antibacterials. However, the flipping mechanism of LLOs including Lipid II remains poorly understood due to a dearth of structural information. Here we report crystal structures of MurJ captured in inward-closed, inward-open, inward-occluded and outward-facing conformations. Together with mutagenesis studies, we elucidate the conformational transitions in MurJ that mediate lipid flipping, identify the key ion for function, and provide a framework for the development of inhibitors.
		+
		+	Visualizing conformation transitions of the Lipid II flippase MurJ.,Kuk ACY, Hao A, Guan Z, Lee SY Nat Commun. 2019 Apr 15;10(1):1736. doi: 10.1038/s41467-019-09658-0. PMID:30988294<ref>PMID:30988294</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6nc8" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
Line 14:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Theab]]
	[[Category: Kuk, A C.Y]]		[[Category: Kuk, A C.Y]]
	[[Category: Lee, S Y]]		[[Category: Lee, S Y]]

OCA at 06:03, 17 April 2019

2019-04-17T06:03:40Z

←Older revision		Revision as of 06:03, 17 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6nc8 is ~~ON HOLD until Paper Publication~~	+	==Lipid II flippase MurJ, inward occluded conformation==
-		+	<StructureSection load='6nc8' size='340' side='right'caption='[[6nc8]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nc8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NC8 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nc8 OCA], [http://pdbe.org/6nc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nc8 RCSB], [http://www.ebi.ac.uk/pdbsum/6nc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nc8 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MURJ_THEAB MURJ_THEAB]] Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.[HAMAP-Rule:MF_02078]<ref>PMID:28024149</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kuk, A C.Y]]
		+	[[Category: Lee, S Y]]
		+	[[Category: Cell wall]]
		+	[[Category: Flippase]]
		+	[[Category: Peptidoglycan]]
		+	[[Category: Transport protein]]
		+	[[Category: Transporter]]

OCA at 05:02, 9 January 2019

2019-01-09T05:02:54Z

←Older revision		Revision as of 05:02, 9 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nc8 is ON HOLD	+	The entry 6nc8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6nc8" [edit=sysop:move=sysop]

2018-12-19T06:36:32Z

Protected "6nc8" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:36, 19 December 2018

OCA: New page: '''Unreleased structure''' The entry 6nc8 is ON HOLD Authors: Description: Category: Unreleased Structures

2018-12-19T06:36:31Z

New page: '''Unreleased structure''' The entry 6nc8 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6nc8 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]