6nfc - Revision history

OCA at 03:22, 11 April 2020

2020-04-11T03:22:10Z

←Older revision		Revision as of 03:22, 11 April 2020
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	<SX load='6nfc' size='340' side='right' viewer='molstar' caption='[[6nfc]], [[Resolution\|resolution]] 3.43Å' scene=''>		<SX load='6nfc' size='340' side='right' viewer='molstar' caption='[[6nfc]], [[Resolution\|resolution]] 3.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nfc]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1], [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFC OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nfc]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1], [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFC OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6NFC FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfc OCA], [http://pdbe.org/6nfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nfc RCSB], [http://www.ebi.ac.uk/pdbsum/6nfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfc ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6nfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfc OCA], [http://pdbe.org/6nfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nfc RCSB], [http://www.ebi.ac.uk/pdbsum/6nfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfc ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 22:51, 6 March 2020

2020-03-06T22:51:04Z

←Older revision		Revision as of 22:51, 6 March 2020
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	==BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding==		==BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding==
-	<~~StructureSection~~ load='6nfc' size='340' side='right'caption='[[6nfc]], [[Resolution\|resolution]] 3.43Å' scene=''>	+	<SX load='6nfc' size='340' side='right' viewer='molstar' caption='[[6nfc]], [[Resolution\|resolution]] 3.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6nfc]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1], [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFC FirstGlance]. <br>		<table><tr><td colspan='2'>[[6nfc]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1], [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFC FirstGlance]. <br>
Line 19:		Line 19:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 11:42, 13 November 2019

2019-11-13T11:42:32Z

←Older revision		Revision as of 11:42, 13 November 2019
Line 3:		Line 3:
	<StructureSection load='6nfc' size='340' side='right'caption='[[6nfc]], [[Resolution\|resolution]] 3.43Å' scene=''>		<StructureSection load='6nfc' size='340' side='right'caption='[[6nfc]], [[Resolution\|resolution]] 3.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nfc]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFC FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nfc]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1], [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFC FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfc OCA], [http://pdbe.org/6nfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nfc RCSB], [http://www.ebi.ac.uk/pdbsum/6nfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfc ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfc OCA], [http://pdbe.org/6nfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nfc RCSB], [http://www.ebi.ac.uk/pdbsum/6nfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfc ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Vaccine induction of broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV) remains a major challenge. Germline-targeting immunogens hold promise for initiating the induction of certain bnAb classes; yet for most bnAbs, a strong dependence on antibody heavy chain complementarity determining region 3 (HCDR3) is a major barrier. Exploiting ultra-deep human antibody sequencing data, we identified a diverse set of potential antibody precursors for a bnAb with dominant HCDR3 contacts. We then developed HIV envelope trimer-based immunogens that primed responses from rare bnAb-precursor B cells in a mouse model, and in ex-vivo screens bound a range of potential bnAb-precursor human naive B cells. Our repertoire-guided germline-targeting approach provides a framework for priming the induction of many HIV bnAbs, and could be applied to most HCDR3-dominant antibodies from other pathogens.
		+
		+	A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses.,Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR Science. 2019 Oct 31. pii: science.aax4380. doi: 10.1126/science.aax4380. PMID:31672916<ref>PMID:31672916</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6nfc" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Macmu]]
	[[Category: Ozorowski, G]]		[[Category: Ozorowski, G]]
	[[Category: Torres, J L]]		[[Category: Torres, J L]]

OCA at 06:44, 6 November 2019

2019-11-06T06:44:16Z

←Older revision		Revision as of 06:44, 6 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6nfc is ON HOLD until Paper Publication~~	+	==BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding==
-		+	<StructureSection load='6nfc' size='340' side='right'caption='[[6nfc]], [[Resolution\|resolution]] 3.43Å' scene=''>
-	~~Authors: Ozorowski, G., Torres, J.L., Ward, A.B.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nfc]] is a 14 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NFC FirstGlance]. <br>
-	~~Description:~~ BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nfc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfc OCA], [http://pdbe.org/6nfc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nfc RCSB], [http://www.ebi.ac.uk/pdbsum/6nfc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfc ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Ward~~, A.B]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Ozorowski, G]]		[[Category: Ozorowski, G]]
-	[[Category: Torres, J.L]]	+	[[Category: Torres, J L]]
		+	[[Category: Ward, A B]]
		+	[[Category: Antibody]]
		+	[[Category: Hiv envelope]]
		+	[[Category: Hiv-1]]
		+	[[Category: Precursor antibody]]
		+	[[Category: Sosip]]
		+	[[Category: Trimer]]
		+	[[Category: Viral protein]]

OCA at 04:10, 19 June 2019

2019-06-19T04:10:24Z

←Older revision		Revision as of 04:10, 19 June 2019
Line 5:		Line 5:
	Authors: Ozorowski, G., Torres, J.L., Ward, A.B.		Authors: Ozorowski, G., Torres, J.L., Ward, A.B.

-	Description: BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 ~~fragment antigen~~ binding and base-binding ~~8D11~~ fragment antigen binding	+	Description: BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragmentantigen binding and base-binding RM20A3 fragment antigen binding
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Ward, A.B]]		[[Category: Ward, A.B]]
	[[Category: Ozorowski, G]]		[[Category: Ozorowski, G]]
	[[Category: Torres, J.L]]		[[Category: Torres, J.L]]

OCA at 05:04, 21 February 2019

2019-02-21T05:04:05Z

←Older revision		Revision as of 05:04, 21 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nfc is ON HOLD	+	The entry 6nfc is ON HOLD until Paper Publication

	Authors: Ozorowski, G., Torres, J.L., Ward, A.B.		Authors: Ozorowski, G., Torres, J.L., Ward, A.B.

OCA: Protected "6nfc" [edit=sysop:move=sysop]

2018-12-26T06:51:33Z

Protected "6nfc" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:51, 26 December 2018

OCA: New page: '''Unreleased structure''' The entry 6nfc is ON HOLD Authors: Ozorowski, G., Torres, J.L., Ward, A.B. Description: BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor ...

2018-12-26T06:51:32Z

New page: '''Unreleased structure''' The entry 6nfc is ON HOLD Authors: Ozorowski, G., Torres, J.L., Ward, A.B. Description: BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor ...

New page

'''Unreleased structure'''

The entry 6nfc is ON HOLD

Authors: Ozorowski, G., Torres, J.L., Ward, A.B.

Description: BG505 MD64 N332-GT5 SOSIP trimer in complex with BG18-like precursor HMP42 fragment antigen binding and base-binding 8D11 fragment antigen binding
[[Category: Unreleased Structures]]
[[Category: Ward, A.B]]
[[Category: Ozorowski, G]]
[[Category: Torres, J.L]]