6nhh - Revision history

OCA at 06:38, 21 August 2019

2019-08-21T06:38:08Z

←Older revision		Revision as of 06:38, 21 August 2019
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	<StructureSection load='6nhh' size='340' side='right'caption='[[6nhh]], [[Resolution\|resolution]] 3.00Å' scene=''>		<StructureSection load='6nhh' size='340' side='right'caption='[[6nhh]], [[Resolution\|resolution]] 3.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nhh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Rhodobacter_sphaeroides_(strain_atcc_17023_/_2.4.1_/_ncib_8253_/_dsm_158) Rhodobacter sphaeroides (strain atcc 17023 / 2.4.1 / ncib 8253 / dsm 158)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NHH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nhh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhos4 Rhos4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NHH FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PE:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>6PE</scene>, <scene name='pdbligand=8SP:O-[(R)-{[(2R)-2,3-BIS(OCTANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>8SP</scene>, <scene name='pdbligand=AZO:METHYL+(2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE'>AZO</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PE:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>6PE</scene>, <scene name='pdbligand=8SP:O-[(R)-{[(2R)-2,3-BIS(OCTANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>8SP</scene>, <scene name='pdbligand=AZO:METHYL+(2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE'>AZO</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kkz\|5kkz]], [[5kli\|5kli]], [[2fyn\|2fyn]], [[2qjk\|2qjk]], [[2qjp\|2qjp]], [[2qjy\|2qjy]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kkz\|5kkz]], [[5kli\|5kli]], [[2fyn\|2fyn]], [[2qjk\|2qjk]], [[2qjp\|2qjp]], [[2qjy\|2qjy]]</td></tr>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Rhos4]]
	[[Category: Ubiquinol--cytochrome-c reductase]]		[[Category: Ubiquinol--cytochrome-c reductase]]
	[[Category: Xia, D]]		[[Category: Xia, D]]

OCA at 07:35, 26 June 2019

2019-06-26T07:35:18Z

←Older revision		Revision as of 07:35, 26 June 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nhh OCA], [http://pdbe.org/6nhh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nhh RCSB], [http://www.ebi.ac.uk/pdbsum/6nhh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nhh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nhh OCA], [http://pdbe.org/6nhh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nhh RCSB], [http://www.ebi.ac.uk/pdbsum/6nhh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nhh ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cytochrome bc1 complexes (cyt bc1), also known as Complex III in mitochondria, are components of the cellular respiratory chain and of the photosynthetic apparatus of nonoxygeneic photosynthetic bacteria. They catalyze electron transfer (ET) from ubiquinol to cytochrome c and concomitantly translocate protons across the membrane, contributing to the cross-membrane potential essential for a myriad of cellular activities. This ET-coupled proton translocation reaction requires a gating mechanism that ensures bifurcated electron flow. Here, we report the observation of the Rieske iron-sulfur protein (ISP) in a mobile state, as revealed by the crystal structure of cyt bc1 from the photosynthetic bacterium Rhodobacter sphaeroides in complex with the fungicide azoxystrobin. Unlike cyt bc1 inhibitors stigmatellin and famoxadone that immobilize the ISP, azoxystrobin causes the ISP to separate from the cyt b subunit and to remain in a mobile state. Analysis of anomalous scattering signals from the iron-sulfur cluster of the ISP suggests the existence of a trajectory for electron delivery. This work supports and solidifies the hypothesis that the bimodal conformation switch of the ISP provides a gating mechanism for bifurcated ET, which is essential to the Qcycle mechanism of cyt bc1 function.
		+
		+	The Crystal Structure of Bacterial Cytochrome bc1 in Complex with Azoxystrobin Reveals a Conformation Switch of the Rieske Iron-Sulfur Protein Subunit.,Esser L, Zhou F, Yu CA, Xia D J Biol Chem. 2019 Jun 10. pii: RA119.008381. doi: 10.1074/jbc.RA119.008381. PMID:31182483<ref>PMID:31182483</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6nhh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:03, 19 June 2019

2019-06-19T06:03:30Z

←Older revision		Revision as of 06:03, 19 June 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6nhh is ~~ON HOLD until Paper Publication~~	+	==Rhodobacter sphaeroides bc1 with azoxystrobin==
-		+	<StructureSection load='6nhh' size='340' side='right'caption='[[6nhh]], [[Resolution\|resolution]] 3.00Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6nhh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides_(strain_atcc_17023_/_2.4.1_/_ncib_8253_/_dsm_158) Rhodobacter sphaeroides (strain atcc 17023 / 2.4.1 / ncib 8253 / dsm 158)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NHH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NHH FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6PE:1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>6PE</scene>, <scene name='pdbligand=8SP:O-[(R)-{[(2R)-2,3-BIS(OCTANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>8SP</scene>, <scene name='pdbligand=AZO:METHYL+(2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE'>AZO</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5kkz\|5kkz]], [[5kli\|5kli]], [[2fyn\|2fyn]], [[2qjk\|2qjk]], [[2qjp\|2qjp]], [[2qjy\|2qjy]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquinol--cytochrome-c_reductase Ubiquinol--cytochrome-c reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.2.2 1.10.2.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nhh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nhh OCA], [http://pdbe.org/6nhh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nhh RCSB], [http://www.ebi.ac.uk/pdbsum/6nhh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nhh ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ubiquinol--cytochrome-c reductase]]
		+	[[Category: Xia, D]]
		+	[[Category: Yu, C A]]
		+	[[Category: Zhou, F]]
		+	[[Category: Cytochrome bc1]]
		+	[[Category: Electron transfer]]
		+	[[Category: Inhibitor]]
		+	[[Category: Mitochondrial respiratory chain complex]]
		+	[[Category: Oxidoreductase]]

OCA at 06:31, 30 January 2019

2019-01-30T06:31:15Z

←Older revision		Revision as of 06:31, 30 January 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6nhh is ON HOLD	+	The entry 6nhh is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6nhh" [edit=sysop:move=sysop]

2019-01-02T04:57:22Z

Protected "6nhh" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:57, 2 January 2019

OCA: New page: '''Unreleased structure''' The entry 6nhh is ON HOLD Authors: Description: Category: Unreleased Structures

2019-01-02T04:57:20Z

New page: '''Unreleased structure''' The entry 6nhh is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6nhh is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]