6nrw - Revision history

OCA at 06:58, 11 October 2023

2023-10-11T06:58:38Z

←Older revision		Revision as of 06:58, 11 October 2023
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	<StructureSection load='6nrw' size='340' side='right'caption='[[6nrw]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6nrw' size='340' side='right'caption='[[6nrw]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nrw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nrw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NRW FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BMA:BETA~~-~~D-MANNOSE'>BMA</scene>~~, ~~<scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max~~-~~height: 3em;~~'>~~[[5eo9\|5eo9]], [[6nrq\|6nrq]], [[6nrr\|6nrr]]~~</~~div~~><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td><~~td class~~=~~"sblockDat">dpr1, dpr, CG13439 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode=5&id=7227 DROME]), DIP-eta, 14010, CT33567, Dmel\CG14010, CG14010, Dmel_CG14010 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nrw OCA], [https://pdbe.org/6nrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nrw RCSB], [https://www.ebi.ac.uk/pdbsum/6nrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nrw ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nrw OCA], [https://pdbe.org/6nrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nrw RCSB], [https://www.ebi.ac.uk/pdbsum/6nrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nrw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8T603_DROME Q8T603_DROME]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cheng, S]]	+	[[Category: Cheng S]]
-	[[Category: Kurleto~~, J D~~]]	+	[[Category: Kurleto JD]]
-	[[Category: Ozkan, E]]	+	[[Category: Ozkan E]]
-	[[Category: Park~~, Y J]]~~	+	[[Category: Park YJ]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Cell surface receptor]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Immunoglobulin superfamily]]~~	+
-	~~[[Category: Neuronal~~]]	+

OCA at 10:37, 18 March 2021

2021-03-18T10:37:08Z

←Older revision		Revision as of 10:37, 18 March 2021
Line 3:		Line 3:
	<StructureSection load='6nrw' size='340' side='right'caption='[[6nrw]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6nrw' size='340' side='right'caption='[[6nrw]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6nrw]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NRW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6NRW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6nrw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NRW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NRW FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=~~FUC~~:~~ALPHA~~-L-~~FUCOSE~~'>~~FUC~~</scene>, <scene name='pdbligand=~~NAG~~:~~N-ACETYL-D-GLUCOSAMINE~~'>~~NAG~~</scene>, <scene name='pdbligand=~~SO4~~:~~SULFATE+ION~~'>~~SO4~~</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5eo9\|5eo9]], [[6nrq\|6nrq]], [[6nrr\|6nrr]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[5eo9\|5eo9]], [[6nrq\|6nrq]], [[6nrr\|6nrr]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dpr1, dpr, CG13439 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), DIP-eta, 14010, CT33567, Dmel\CG14010, CG14010, Dmel_CG14010 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dpr1, dpr, CG13439 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), DIP-eta, 14010, CT33567, Dmel\CG14010, CG14010, Dmel_CG14010 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6nrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nrw OCA], [~~http~~://pdbe.org/6nrw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6nrw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6nrw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6nrw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nrw OCA], [https://pdbe.org/6nrw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nrw RCSB], [https://www.ebi.ac.uk/pdbsum/6nrw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nrw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 11:43, 18 December 2019

2019-12-18T11:43:05Z

←Older revision		Revision as of 11:43, 18 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6nrw is ~~ON HOLD~~	+	==Crystal structure of Dpr1 IG1 bound to DIP-eta IG1==
		+	<StructureSection load='6nrw' size='340' side='right'caption='[[6nrw]], [[Resolution\|resolution]] 2.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6nrw]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NRW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NRW FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5eo9\|5eo9]], [[6nrq\|6nrq]], [[6nrr\|6nrr]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">dpr1, dpr, CG13439 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME]), DIP-eta, 14010, CT33567, Dmel\CG14010, CG14010, Dmel_CG14010 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nrw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nrw OCA], [http://pdbe.org/6nrw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nrw RCSB], [http://www.ebi.ac.uk/pdbsum/6nrw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nrw ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In stereotyped neuronal networks, synaptic connectivity is dictated by cell surface proteins, which assign unique identities to neurons, and physically mediate axon guidance and synapse targeting. We recently identified two groups of immunoglobulin superfamily proteins in Drosophila, Dprs and DIPs, as strong candidates for synapse targeting functions. Here, we uncover the molecular basis of specificity in Dpr-DIP mediated cellular adhesions and neuronal connectivity. First, we present five crystal structures of Dpr-DIP and DIP-DIP complexes, highlighting the evolutionary and structural origins of diversification in Dpr and DIP proteins and their interactions. We further show that structures can be used to rationally engineer receptors with novel specificities or modified affinities, which can be used to study specific circuits that require Dpr-DIP interactions to help establish connectivity. We investigate one pair, engineered Dpr10 and DIP-alpha, for function in the neuromuscular circuit in flies, and reveal roles for homophilic and heterophilic binding in wiring.

-	~~Authors: Cheng~~, S., ~~Park, Y.~~J., Kurleto, ~~J.D.~~, ~~Ozkan~~, E.	+	Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila.,Cheng S, Ashley J, Kurleto JD, Lobb-Rabe M, Park YJ, Carrillo RA, Ozkan E Elife. 2019 Jan 28;8. pii: 41028. doi: 10.7554/eLife.41028. PMID:30688651<ref>PMID:30688651</ref>

-	~~Description: Crystal structure~~ of ~~Dpr1 IG1 bound to DIP~~-~~eta IG1~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Ozkan, E~~]]	+	<div class="pdbe-citations 6nrw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Cheng, S]]		[[Category: Cheng, S]]
-	[[Category: Kurleto, J.D]]	+	[[Category: Kurleto, J D]]
-	[[Category: Park, Y.J]]	+	[[Category: Ozkan, E]]
		+	[[Category: Park, Y J]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Cell surface receptor]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Immunoglobulin superfamily]]
		+	[[Category: Neuronal]]

OCA: Protected "6nrw" [edit=sysop:move=sysop]

2019-01-30T06:50:10Z

Protected "6nrw" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:50, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6nrw is ON HOLD Authors: Cheng, S., Park, Y.J., Kurleto, J.D., Ozkan, E. Description: Crystal structure of Dpr1 IG1 bound to DIP-eta IG1 [[Category...

2019-01-30T06:50:08Z

New page: '''Unreleased structure''' The entry 6nrw is ON HOLD Authors: Cheng, S., Park, Y.J., Kurleto, J.D., Ozkan, E. Description: Crystal structure of Dpr1 IG1 bound to DIP-eta IG1 [[Category...

New page

'''Unreleased structure'''

The entry 6nrw is ON HOLD

Authors: Cheng, S., Park, Y.J., Kurleto, J.D., Ozkan, E.

Description: Crystal structure of Dpr1 IG1 bound to DIP-eta IG1
[[Category: Unreleased Structures]]
[[Category: Ozkan, E]]
[[Category: Cheng, S]]
[[Category: Kurleto, J.D]]
[[Category: Park, Y.J]]