6o19 - Revision history

OCA at 07:02, 11 October 2023

2023-10-11T07:02:58Z

←Older revision		Revision as of 07:02, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6o19' size='340' side='right'caption='[[6o19]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6o19' size='340' side='right'caption='[[6o19]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o19]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cbs_356 Cbs 356~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O19 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o19]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O19 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.596Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[6e33\|6e33]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">pi067, SPBC27B12.11c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o19 OCA], [https://pdbe.org/6o19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o19 RCSB], [https://www.ebi.ac.uk/pdbsum/6o19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o19 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o19 OCA], [~~http~~://pdbe.org/6o19 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o19 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o19 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o19 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/YBCB_SCHPO YBCB_SCHPO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Cbs 356]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Garg, A~~]]	+	[[Category: Schizosaccharomyces pombe]]
-	[[Category: ~~Goldgur, Y~~]]	+	[[Category: Garg A]]
-	[[Category: ~~Shuman, S~~]]	+	[[Category: Goldgur Y]]
-	[[Category: ~~Pho7]]~~	+	[[Category: Shuman S]]
-	~~[[Category: Transcription]]~~	+
-	~~[[Category: Transcription factor-dna complex]]~~	+
-	~~[[Category: Transcription-dna complex]]~~	+
-	~~[[Category: Zinc binuclear cluster transcription factor]]~~	+
-	~~[[Category: Zn2cys6~~]]	+

OCA at 13:43, 10 May 2019

2019-05-10T13:43:25Z

←Older revision		Revision as of 13:43, 10 May 2019
Line 3:		Line 3:
	<StructureSection load='6o19' size='340' side='right'caption='[[6o19]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='6o19' size='340' side='right'caption='[[6o19]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o19]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o19]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_356 Cbs 356]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O19 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6e33\|6e33]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6e33\|6e33]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">pi067, SPBC27B12.11c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4896 CBS 356])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o19 OCA], [http://pdbe.org/6o19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o19 RCSB], [http://www.ebi.ac.uk/pdbsum/6o19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o19 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o19 OCA], [http://pdbe.org/6o19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o19 RCSB], [http://www.ebi.ac.uk/pdbsum/6o19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o19 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pho7 is the fission yeast Zn2Cys6 transcriptional factor that drives a response to phosphate starvation in which phosphate acquisition genes are upregulated. Here we report a crystal structure at 1.6 A resolution of the Pho7 DNA-binding domain (DBD) bound at its target site 2 in the pho1 promoter (5'-TCGGAAATTAAAAA). Comparison to the previously reported structure of Pho7 DBD in complex with its binding site in the tgp1 promoter (5'-TCGGACATTCAAAT) reveals shared determinants of target site specificity as well as variations in the protein-DNA interface that accommodate different promoter DNA sequences. Mutagenesis of Pho7 amino acids at the DNA interface identified nucleobase contacts at the periphery of the footprint that are essential for the induction of pho1 expression in response to phosphate starvation and for Pho7 binding to site 1 in the pho1 promoter.
		+
		+	Structure of fission yeast transcription factor Pho7 bound to pho1 promoter DNA and effect of Pho7 mutations on DNA binding and phosphate homeostasis.,Garg A, Goldgur Y, Sanchez AM, Schwer B, Shuman S Mol Cell Biol. 2019 Apr 22. pii: MCB.00132-19. doi: 10.1128/MCB.00132-19. PMID:31010807<ref>PMID:31010807</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6o19" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 356]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Garg, A]]		[[Category: Garg, A]]

OCA at 07:03, 24 April 2019

2019-04-24T07:03:34Z

←Older revision		Revision as of 07:03, 24 April 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6o19 is ~~ON HOLD until Paper Publication~~	+	==Crystal Structure of Pho7 complex with pho1 promoter site 2==
-		+	<StructureSection load='6o19' size='340' side='right'caption='[[6o19]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Garg~~, A., ~~Goldgur~~, Y., ~~Shuman~~, S.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6o19]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O19 FirstGlance]. <br>
-	~~Description: Crystal Structure of Pho7 complex with pho1 promoter site 2~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6e33\|6e33]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o19 OCA], [http://pdbe.org/6o19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o19 RCSB], [http://www.ebi.ac.uk/pdbsum/6o19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o19 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Garg, A]]
	[[Category: Goldgur, Y]]		[[Category: Goldgur, Y]]
-	[[Category: Garg, A]]
	[[Category: Shuman, S]]		[[Category: Shuman, S]]
		+	[[Category: Pho7]]
		+	[[Category: Transcription]]
		+	[[Category: Transcription factor-dna complex]]
		+	[[Category: Transcription-dna complex]]
		+	[[Category: Zinc binuclear cluster transcription factor]]
		+	[[Category: Zn2cys6]]

OCA: Protected "6o19" [edit=sysop:move=sysop]

2019-02-27T13:49:36Z

Protected "6o19" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:49, 27 February 2019

OCA: New page: '''Unreleased structure''' The entry 6o19 is ON HOLD until Paper Publication Authors: Garg, A., Goldgur, Y., Shuman, S. Description: Crystal Structure of Pho7 complex with pho1 promote...

2019-02-27T13:49:35Z

New page: '''Unreleased structure''' The entry 6o19 is ON HOLD until Paper Publication Authors: Garg, A., Goldgur, Y., Shuman, S. Description: Crystal Structure of Pho7 complex with pho1 promote...

New page

'''Unreleased structure'''

The entry 6o19 is ON HOLD until Paper Publication

Authors: Garg, A., Goldgur, Y., Shuman, S.

Description: Crystal Structure of Pho7 complex with pho1 promoter site 2
[[Category: Unreleased Structures]]
[[Category: Goldgur, Y]]
[[Category: Garg, A]]
[[Category: Shuman, S]]