6o5c - Revision history

OCA at 07:04, 11 October 2023

2023-10-11T07:04:50Z

←Older revision		Revision as of 07:04, 11 October 2023
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	<StructureSection load='6o5c' size='340' side='right'caption='[[6o5c]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='6o5c' size='340' side='right'caption='[[6o5c]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o5c]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Streptococcus_pyogenes_(serotype_m3)~~ Streptococcus pyogenes (serotype ~~m3)~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O5C OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6O5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M3 Streptococcus pyogenes serotype M3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O5C FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6o5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5c OCA], [~~http~~://pdbe.org/6o5c PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6o5c RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6o5c PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5c ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5c OCA], [https://pdbe.org/6o5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o5c RCSB], [https://www.ebi.ac.uk/pdbsum/6o5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5c ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A0H2UTK0_STRP3 A0A0H2UTK0_STRP3]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Do, H~~]]	+	[[Category: Streptococcus pyogenes serotype M3]]
-	[[Category: ~~Kumaraswami, M~~]]	+	[[Category: Do H]]
-	[[Category: ~~Dna binding protein]]~~	+	[[Category: Kumaraswami M]]
-	~~[[Category: Manganese]]~~	+
-	~~[[Category: Transcription regulator~~]]	+

OCA at 16:02, 28 August 2019

2019-08-28T16:02:06Z

←Older revision		Revision as of 16:02, 28 August 2019
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	<StructureSection load='6o5c' size='340' side='right'caption='[[6o5c]], [[Resolution\|resolution]] 3.10Å' scene=''>		<StructureSection load='6o5c' size='340' side='right'caption='[[6o5c]], [[Resolution\|resolution]] 3.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6o5c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O5C FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6o5c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_(serotype_m3) Streptococcus pyogenes (serotype m3)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O5C FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5c OCA], [http://pdbe.org/6o5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o5c RCSB], [http://www.ebi.ac.uk/pdbsum/6o5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5c OCA], [http://pdbe.org/6o5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o5c RCSB], [http://www.ebi.ac.uk/pdbsum/6o5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5c ProSAT]</span></td></tr>

OCA at 07:38, 26 June 2019

2019-06-26T07:38:09Z

←Older revision		Revision as of 07:38, 26 June 2019
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5c OCA], [http://pdbe.org/6o5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o5c RCSB], [http://www.ebi.ac.uk/pdbsum/6o5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5c ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5c OCA], [http://pdbe.org/6o5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o5c RCSB], [http://www.ebi.ac.uk/pdbsum/6o5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5c ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Pathogenic bacteria encounter host-imposed manganese (Mn) limitation during infection. Herein we report that in the human pathogen Streptococcus pyogenes, the adaptive response to Mn limitation is controlled by a DtxR family metalloregulator, MtsR. Genes upregulated by MtsR during Mn limitation include Mn (mtsABC) and Fe acquisition systems (sia operon), and a metal-independent DNA synthesis enzyme (nrdFEI.2). To elucidate the mechanism of metal sensing and gene regulation by MtsR, we determined the crystal structure of MtsR. MtsR employs two Mn-sensing sites to monitor metal availability, and metal occupancy at each site influences MtsR regulatory activity. The site 1 acts as the primary Mn sensing site, and loss of metal at site 1 causes robust upregulation of mtsABC. The vacant site 2 causes partial induction of mtsABC, indicating that site 2 functions as secondary Mn sensing site. Furthermore, we show that the C-terminal FeoA domains of adjacent dimers participate in the oligomerization of MtsR on DNA, and multimerization is critical for MtsR regulatory activity. Finally, the mtsR mutant strains defective in metal sensing and oligomerization are attenuated for virulence in a mouse model of invasive infection, indicating that Mn sensing and gene regulation by MtsR are critical processes during S. pyogenes infection.
		+
		+	Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.,Do H, Makthal N, Chandrangsu P, Olsen RJ, Helmann JD, Musser JM, Kumaraswami M Nucleic Acids Res. 2019 Jun 12. pii: 5514186. doi: 10.1093/nar/gkz524. PMID:31188450<ref>PMID:31188450</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6o5c" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 05:42, 12 June 2019

2019-06-12T05:42:11Z

←Older revision		Revision as of 05:42, 12 June 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6o5c is ON HOLD~~	+	==X-ray crystal structure of metal-dependent transcriptional regulator MtsR==
-		+	<StructureSection load='6o5c' size='340' side='right'caption='[[6o5c]], [[Resolution\|resolution]] 3.10Å' scene=''>
-	~~Authors: Do, H., Kumaraswami, M.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6o5c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O5C FirstGlance]. <br>
-	~~Description:~~ X-ray crystal structure of metal-dependent transcriptional regulator MtsR	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o5c OCA], [http://pdbe.org/6o5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o5c RCSB], [http://www.ebi.ac.uk/pdbsum/6o5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o5c ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Do, H]]		[[Category: Do, H]]
	[[Category: Kumaraswami, M]]		[[Category: Kumaraswami, M]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Manganese]]
		+	[[Category: Transcription regulator]]

OCA: Protected "6o5c" [edit=sysop:move=sysop]

2019-03-13T10:13:47Z

Protected "6o5c" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:13, 13 March 2019

OCA: New page: '''Unreleased structure''' The entry 6o5c is ON HOLD Authors: Do, H., Kumaraswami, M. Description: X-ray crystal structure of metal-dependent transcriptional regulator MtsR [[Category:...

2019-03-13T10:13:46Z

New page: '''Unreleased structure''' The entry 6o5c is ON HOLD Authors: Do, H., Kumaraswami, M. Description: X-ray crystal structure of metal-dependent transcriptional regulator MtsR [[Category:...

New page

'''Unreleased structure'''

The entry 6o5c is ON HOLD

Authors: Do, H., Kumaraswami, M.

Description: X-ray crystal structure of metal-dependent transcriptional regulator MtsR
[[Category: Unreleased Structures]]
[[Category: Do, H]]
[[Category: Kumaraswami, M]]