6oap - Revision history

OCA at 07:07, 11 October 2023

2023-10-11T07:07:06Z

←Older revision		Revision as of 07:07, 11 October 2023
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	<StructureSection load='6oap' size='340' side='right'caption='[[6oap]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='6oap' size='340' side='right'caption='[[6oap]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6oap]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Leptolyngbya_sp.~~_jsc~~-1 Leptolyngbya sp. ~~jsc~~-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OAP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OAP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6oap]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leptolyngbya_sp._JSC-1 Leptolyngbya sp. JSC-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OAP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OAP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.97Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6oap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oap OCA], [~~http~~://pdbe.org/6oap PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6oap RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6oap PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6oap ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oap OCA], [https://pdbe.org/6oap PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oap RCSB], [https://www.ebi.ac.uk/pdbsum/6oap PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oap ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Leptolyngbya sp. jsc-1]]~~	+	[[Category: Heewhan S]]
-	[[Category: Heewhan, S]]	+	[[Category: Sepalika B]]
-	[[Category: Sepalika, B]]	+	[[Category: Xiaojing Y]]
-	[[Category: Xiaojing, Y]]	+	[[Category: Xiaoli Z]]
-	[[Category: Xiaoli, Z]]	+	[[Category: Zhong R]]
-	[[Category: Zhong, R]]	+
-	~~[[Category: Cyanobacteriochrome]]~~	+
-	~~[[Category: Photoreceptor]]~~	+
-	~~[[Category: Signaling protein]]~~	+
-	~~[[Category: Tandem sensor~~]]	+

OCA at 11:44, 13 November 2019

2019-11-13T11:44:31Z

←Older revision		Revision as of 11:44, 13 November 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6oap is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of a dual sensor histidine kinase in the green-light absorbing Pg state==
		+	<StructureSection load='6oap' size='340' side='right'caption='[[6oap]], [[Resolution\|resolution]] 1.97Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6oap]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Leptolyngbya_sp._jsc-1 Leptolyngbya sp. jsc-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OAP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OAP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYC:PHYCOCYANOBILIN'>CYC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oap FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oap OCA], [http://pdbe.org/6oap PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oap RCSB], [http://www.ebi.ac.uk/pdbsum/6oap PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oap ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Signal detection and integration by sensory proteins constitute the critical molecular events as living organisms respond to changes in a complex environment. Many sensory proteins adopt a modular architecture that integrates the perception of distinct chemical or physical signals and the generation of a biological response in the same protein molecule. Currently, how signal perception and integration are achieved in such a modular, often dimeric, framework remains elusive. Here, we report a dynamic crystallography study on the tandem sensor domains of a dual-sensor histidine kinase PPHK (phosphorylation-responsive photosensitive histidine kinase) that operates a molecular logic OR, by which the output kinase activity is modulated by a phosphorylation signal and a light signal. A joint analysis of approximately 170 crystallographic datasets probing different signaling states shows remarkable dimer asymmetry as PPHK responds to the input signals and transitions from one state to the other. Supported by mutational data and structural analysis, these direct observations reveal the working mechanics of the molecular logic OR in PPHK, where the light-induced bending of a long signaling helix at the dimer interface is counteracted by the ligand-induced structural changes from a different sensor domain. We propose that the logic OR of PPHK, together with an upstream photoreceptor, implements a "long-pass" red light response distinct from those accomplished by classical phytochromes.

-	~~Authors~~:	+	Structural basis of molecular logic OR in a dual-sensor histidine kinase.,Shin H, Ren Z, Zeng X, Bandara S, Yang X Proc Natl Acad Sci U S A. 2019 Oct 1;116(40):19973-19982. doi:, 10.1073/pnas.1910855116. Epub 2019 Sep 16. PMID:31527275<ref>PMID:31527275</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6oap" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Leptolyngbya sp. jsc-1]]
		+	[[Category: Heewhan, S]]
		+	[[Category: Sepalika, B]]
		+	[[Category: Xiaojing, Y]]
		+	[[Category: Xiaoli, Z]]
		+	[[Category: Zhong, R]]
		+	[[Category: Cyanobacteriochrome]]
		+	[[Category: Photoreceptor]]
		+	[[Category: Signaling protein]]
		+	[[Category: Tandem sensor]]

OCA at 04:10, 19 June 2019

2019-06-19T04:10:56Z

←Older revision		Revision as of 04:10, 19 June 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6oap is ON HOLD	+	The entry 6oap is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6oap" [edit=sysop:move=sysop]

2019-03-27T05:03:26Z

Protected "6oap" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:03, 27 March 2019

OCA: New page: '''Unreleased structure''' The entry 6oap is ON HOLD Authors: Description: Category: Unreleased Structures

2019-03-27T05:03:25Z

New page: '''Unreleased structure''' The entry 6oap is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6oap is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]