6ocb - Revision history

OCA at 07:08, 11 October 2023

2023-10-11T07:08:05Z

←Older revision		Revision as of 07:08, 11 October 2023
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	<StructureSection load='6ocb' size='340' side='right'caption='[[6ocb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6ocb' size='340' side='right'caption='[[6ocb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ocb]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~I68a4 I68a4~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OCB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6OCB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ocb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Hong_Kong/1/1968(H3N2)) Influenza A virus (A/Hong Kong/1/1968(H3N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OCB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OCB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=NAG:N~~-~~ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=506350 I68A4])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ocb OCA], [~~http~~://pdbe.org/6ocb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ocb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ocb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ocb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ocb OCA], [https://pdbe.org/6ocb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ocb RCSB], [https://www.ebi.ac.uk/pdbsum/6ocb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ocb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).	+	[https://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]		*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
	== References ==		== References ==
Line 26:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: I68a4~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Lang, S]]	+	[[Category: Lang S]]
-	[[Category: Wilson~~, I A]]~~	+	[[Category: Wilson IA]]
-	~~[[Category: Anti-flu antibody]]~~	+
-	~~[[Category: Ha head domain]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 06:46, 9 December 2020

2020-12-09T06:46:26Z

←Older revision		Revision as of 06:46, 9 December 2020
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	<StructureSection load='6ocb' size='340' side='right'caption='[[6ocb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6ocb' size='340' side='right'caption='[[6ocb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ocb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/I68a4 I68a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OCB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OCB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ocb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/I68a4 I68a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OCB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OCB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=506350 I68A4])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=506350 I68A4])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ocb OCA], [http://pdbe.org/6ocb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ocb RCSB], [http://www.ebi.ac.uk/pdbsum/6ocb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ocb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ocb OCA], [http://pdbe.org/6ocb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ocb RCSB], [http://www.ebi.ac.uk/pdbsum/6ocb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ocb ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).		[[http://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here, we describe the discovery of a naturally occurring human antibody (Ab), FluA-20, that recognizes a new site of vulnerability on the hemagglutinin (HA) head domain and reacts with most influenza A viruses. Structural characterization of FluA-20 with H1 and H3 head domains revealed a novel epitope in the HA trimer interface, suggesting previously unrecognized dynamic features of the trimeric HA protein. The critical HA residues recognized by FluA-20 remain conserved across most subtypes of influenza A viruses, which explains the Ab's extraordinary breadth. The Ab rapidly disrupted the integrity of HA protein trimers, inhibited cell-to-cell spread of virus in culture, and protected mice against challenge with viruses of H1N1, H3N2, H5N1, or H7N9 subtypes when used as prophylaxis or therapy. The FluA-20 Ab has uncovered an exceedingly conserved protective determinant in the influenza HA head domain trimer interface that is an unexpected new target for anti-influenza therapeutics and vaccines.
		+
		+	A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface.,Bangaru S, Lang S, Schotsaert M, Vanderven HA, Zhu X, Kose N, Bombardi R, Finn JA, Kent SJ, Gilchuk P, Gilchuk I, Turner HL, Garcia-Sastre A, Li S, Ward AB, Wilson IA, Crowe JE Jr Cell. 2019 May 16;177(5):1136-1152.e18. doi: 10.1016/j.cell.2019.04.011. PMID:31100268<ref>PMID:31100268</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ocb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin 3D structures\|Hemagglutinin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 10:40, 4 December 2019

2019-12-04T10:40:26Z

←Older revision		Revision as of 10:40, 4 December 2019
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	<StructureSection load='6ocb' size='340' side='right'caption='[[6ocb]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='6ocb' size='340' side='right'caption='[[6ocb]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ocb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OCB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ocb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/I68a4 I68a4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OCB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=506350 I68A4])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ocb OCA], [http://pdbe.org/6ocb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ocb RCSB], [http://www.ebi.ac.uk/pdbsum/6ocb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ocb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ocb OCA], [http://pdbe.org/6ocb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ocb RCSB], [http://www.ebi.ac.uk/pdbsum/6ocb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ocb ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: I68a4]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Lang, S]]		[[Category: Lang, S]]

OCA at 06:18, 29 May 2019

2019-05-29T06:18:21Z

←Older revision		Revision as of 06:18, 29 May 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 6ocb is ON HOLD until Paper Publication~~	+	==Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/1968)==
-		+	<StructureSection load='6ocb' size='340' side='right'caption='[[6ocb]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors: Wilson, I.A., Lang, S.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ocb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OCB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OCB FirstGlance]. <br>
-	~~Description:~~ Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/1968)	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ocb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ocb OCA], [http://pdbe.org/6ocb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ocb RCSB], [http://www.ebi.ac.uk/pdbsum/6ocb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ocb ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Wilson~~, I.A]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/HEMA_I68A4 HEMA_I68A4]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lang, S]]		[[Category: Lang, S]]
		+	[[Category: Wilson, I A]]
		+	[[Category: Anti-flu antibody]]
		+	[[Category: Ha head domain]]
		+	[[Category: Immune system]]

OCA at 07:47, 10 May 2019

2019-05-10T07:47:59Z

←Older revision		Revision as of 07:47, 10 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ocb is ON HOLD	+	The entry 6ocb is ON HOLD until Paper Publication

	Authors: Wilson, I.A., Lang, S.		Authors: Wilson, I.A., Lang, S.

OCA: Protected "6ocb" [edit=sysop:move=sysop]

2019-04-03T04:38:47Z

Protected "6ocb" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:38, 3 April 2019

OCA: New page: '''Unreleased structure''' The entry 6ocb is ON HOLD Authors: Wilson, I.A., Lang, S. Description: Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/...

2019-04-03T04:38:45Z

New page: '''Unreleased structure''' The entry 6ocb is ON HOLD Authors: Wilson, I.A., Lang, S. Description: Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/...

New page

'''Unreleased structure'''

The entry 6ocb is ON HOLD

Authors: Wilson, I.A., Lang, S.

Description: Crystal structure of FluA-20 Fab in complex with the head domain of H3 (A/Hong Kong/1/1968)
[[Category: Unreleased Structures]]
[[Category: Wilson, I.A]]
[[Category: Lang, S]]