6oee - Revision history

OCA at 14:51, 13 March 2024

2024-03-13T14:51:41Z

←Older revision		Revision as of 14:51, 13 March 2024
Line 3:		Line 3:
	<SX load='6oee' size='340' side='right' viewer='molstar' caption='[[6oee]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6oee' size='340' side='right' viewer='molstar' caption='[[6oee]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6oee]] is a 14 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6OEE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6oee]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OEE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6oee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oee OCA], [~~http~~://pdbe.org/6oee PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6oee RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6oee PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6oee ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.8Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6oee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oee OCA], [https://pdbe.org/6oee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6oee RCSB], [https://www.ebi.ac.uk/pdbsum/6oee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6oee ProSAT]</span></td></tr>
	</table>		</table>
-	~~<div style~~=~~"background-color:#fffaf0;">~~	+	== Function ==
-	=~~= Publication Abstract from PubMed~~ ==	+	[https://www.uniprot.org/uniprot/CAGT_HELPY CAGT_HELPY]
-	Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS complex, which contains three sub-complexes: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and stalk domain. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system complexes ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.	+
-		+
-	Structure of the Helicobacter pylori Cag Type IV secretion system.,Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD Elife. 2019 Jun 18;8. pii: 47644. doi: 10.7554/~~eLife.47644. PMID:31210639<ref>PMID:31210639<~~/~~ref>~~	+
-		+
-	~~From MEDLINE®/PubMed®, a database of the U~~.S. ~~National Library of Medicine.<br>~~	+
-	</~~div>~~	+
-	~~<div class="pdbe-citations 6oee" style="background-color:#fffaf0;"></div>~~	+
-	~~== References ==~~	+
-	~~<references~~/>	+
	__TOC__		__TOC__
	</SX>		</SX>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Campbell, A]]	+	[[Category: Campbell A]]
-	[[Category: Chung~~, J M~~]]	+	[[Category: Chung JM]]
-	[[Category: Cover~~, T L~~]]	+	[[Category: Cover TL]]
-	[[Category: Frick-Cheng~~, A E~~]]	+	[[Category: Frick-Cheng AE]]
-	[[Category: Lacy~~, D B~~]]	+	[[Category: Lacy DB]]
-	[[Category: Ohi~~, M D~~]]	+	[[Category: Ohi MD]]
-	[[Category: Sawhney, N]]	+	[[Category: Sawhney N]]
-	[[Category: Sheedlo~~, M J]]~~	+	[[Category: Sheedlo MJ]]
-	~~[[Category: H. pylori]]~~	+
-	~~[[Category: Secretion]]~~	+
-	~~[[Category: T4ss]]~~	+
-	~~[[Category: Translocase~~]]	+

OCA at 03:52, 11 April 2020

2020-04-11T03:52:37Z

←Older revision		Revision as of 03:52, 11 April 2020
Line 3:		Line 3:
	<SX load='6oee' size='340' side='right' viewer='molstar' caption='[[6oee]], [[Resolution\|resolution]] 3.80Å' scene=''>		<SX load='6oee' size='340' side='right' viewer='molstar' caption='[[6oee]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6oee]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OEE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6oee]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6OEE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6oee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oee OCA], [http://pdbe.org/6oee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oee RCSB], [http://www.ebi.ac.uk/pdbsum/6oee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oee ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6oee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oee OCA], [http://pdbe.org/6oee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oee RCSB], [http://www.ebi.ac.uk/pdbsum/6oee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oee ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:10, 6 March 2020

2020-03-06T23:10:02Z

←Older revision		Revision as of 23:10, 6 March 2020
Line 1:		Line 1:

	==Structure of CagT from a cryo-EM reconstruction of a T4SS==		==Structure of CagT from a cryo-EM reconstruction of a T4SS==
-	<~~StructureSection~~ load='6oee' size='340' side='right'caption='[[6oee]], [[Resolution\|resolution]] 3.80Å' scene=''>	+	<SX load='6oee' size='340' side='right' viewer='molstar' caption='[[6oee]], [[Resolution\|resolution]] 3.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6oee]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEE FirstGlance]. <br>		<table><tr><td colspan='2'>[[6oee]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEE FirstGlance]. <br>
Line 18:		Line 18:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Helicobacter pylori]]		[[Category: Helicobacter pylori]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 05:57, 3 July 2019

2019-07-03T05:57:57Z

←Older revision		Revision as of 05:57, 3 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6oee is ~~ON HOLD~~	+	==Structure of CagT from a cryo-EM reconstruction of a T4SS==
		+	<StructureSection load='6oee' size='340' side='right'caption='[[6oee]], [[Resolution\|resolution]] 3.80Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6oee]] is a 14 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OEE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OEE FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6oee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6oee OCA], [http://pdbe.org/6oee PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6oee RCSB], [http://www.ebi.ac.uk/pdbsum/6oee PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6oee ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bacterial type IV secretion systems (T4SSs) are molecular machines that can mediate interbacterial DNA transfer through conjugation and delivery of effector molecules into host cells. The Helicobacter pylori Cag T4SS translocates CagA, a bacterial oncoprotein, into gastric cells, contributing to gastric cancer pathogenesis. We report the structure of a membrane-spanning Cag T4SS complex, which contains three sub-complexes: a 14-fold symmetric outer membrane core complex (OMCC), 17-fold symmetric periplasmic ring complex (PRC), and stalk domain. Features that differ markedly from those of prototypical T4SSs include an expanded OMCC and unexpected symmetry mismatch between the OMCC and PRC. This structure is one of the largest bacterial secretion system complexes ever reported and illustrates the remarkable structural diversity that exists among bacterial T4SSs.

-	~~Authors~~:	+	Structure of the Helicobacter pylori Cag Type IV secretion system.,Chung JM, Sheedlo MJ, Campbell AM, Sawhney N, Frick-Cheng AE, Lacy DB, Cover TL, Ohi MD Elife. 2019 Jun 18;8. pii: 47644. doi: 10.7554/eLife.47644. PMID:31210639<ref>PMID:31210639</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6oee" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Helicobacter pylori]]
		+	[[Category: Large Structures]]
		+	[[Category: Campbell, A]]
		+	[[Category: Chung, J M]]
		+	[[Category: Cover, T L]]
		+	[[Category: Frick-Cheng, A E]]
		+	[[Category: Lacy, D B]]
		+	[[Category: Ohi, M D]]
		+	[[Category: Sawhney, N]]
		+	[[Category: Sheedlo, M J]]
		+	[[Category: H. pylori]]
		+	[[Category: Secretion]]
		+	[[Category: T4ss]]
		+	[[Category: Translocase]]

OCA: Protected "6oee" [edit=sysop:move=sysop]

2019-04-03T04:46:47Z

Protected "6oee" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:46, 3 April 2019

OCA: New page: '''Unreleased structure''' The entry 6oee is ON HOLD Authors: Description: Category: Unreleased Structures

2019-04-03T04:46:46Z

New page: '''Unreleased structure''' The entry 6oee is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6oee is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]