6ohq - Revision history

OCA at 07:10, 11 October 2023

2023-10-11T07:10:50Z

←Older revision		Revision as of 07:10, 11 October 2023
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	<StructureSection load='6ohq' size='340' side='right'caption='[[6ohq]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='6ohq' size='340' side='right'caption='[[6ohq]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ohq]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OHQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6OHQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ohq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OHQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MKA:4-fluoro-N-{(2S)-1-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl}benzamide'>MKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.694Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MKA:4-fluoro-N-{(2S)-1-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl}benzamide'>MKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_D Phospholipase D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.4 3.1.4.4] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ohq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ohq OCA], [https://pdbe.org/6ohq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ohq RCSB], [https://www.ebi.ac.uk/pdbsum/6ohq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ohq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ohq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ohq OCA], [~~http~~://pdbe.org/6ohq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ohq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ohq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ohq ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PLD2_HUMAN PLD2_HUMAN]] May have a role in signal-induced cytoskeletal regulation and/or endocytosis.	+	[https://www.uniprot.org/uniprot/PLD2_HUMAN PLD2_HUMAN] May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6ohq" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6ohq" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Phospholipase D 3D structures\|Phospholipase D 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Phospholipase D]]~~	+	[[Category: Chodaparambil JV]]
-	[[Category: Chodaparambil~~, J V~~]]	+	[[Category: Metrick CM]]
-	[[Category: Metrick~~, C M]]~~	+
-	~~[[Category: Hkd motif]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Hydrolase-hydrolase inhibitor complex]]~~	+
-	~~[[Category: Phosphodiesterase~~]]	+

OCA at 09:36, 1 April 2020

2020-04-01T09:36:37Z

←Older revision		Revision as of 09:36, 1 April 2020
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	<StructureSection load='6ohq' size='340' side='right'caption='[[6ohq]], [[Resolution\|resolution]] 2.69Å' scene=''>		<StructureSection load='6ohq' size='340' side='right'caption='[[6ohq]], [[Resolution\|resolution]] 2.69Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ohq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OHQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ohq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OHQ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MKA:4-fluoro-N-{(2S)-1-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl}benzamide'>MKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MKA:4-fluoro-N-{(2S)-1-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl}benzamide'>MKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PLD2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_D Phospholipase D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.4 3.1.4.4] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_D Phospholipase D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.4 3.1.4.4] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ohq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ohq OCA], [http://pdbe.org/6ohq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ohq RCSB], [http://www.ebi.ac.uk/pdbsum/6ohq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ohq ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ohq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ohq OCA], [http://pdbe.org/6ohq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ohq RCSB], [http://www.ebi.ac.uk/pdbsum/6ohq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ohq ProSAT]</span></td></tr>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Phospholipase D]]		[[Category: Phospholipase D]]

OCA at 06:25, 19 February 2020

2020-02-19T06:25:16Z

←Older revision		Revision as of 06:25, 19 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ohq is ~~ON HOLD until Paper~~ Publication	+	==Structure of compound 4 bound human Phospholipase D2 catalytic domain==
		+	<StructureSection load='6ohq' size='340' side='right'caption='[[6ohq]], [[Resolution\|resolution]] 2.69Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6ohq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OHQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6OHQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MKA:4-fluoro-N-{(2S)-1-[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]propan-2-yl}benzamide'>MKA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_D Phospholipase D], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.4 3.1.4.4] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ohq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ohq OCA], [http://pdbe.org/6ohq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ohq RCSB], [http://www.ebi.ac.uk/pdbsum/6ohq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ohq ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PLD2_HUMAN PLD2_HUMAN]] May have a role in signal-induced cytoskeletal regulation and/or endocytosis.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phospholipase D enzymes (PLDs) are ubiquitous phosphodiesterases that produce phosphatidic acid (PA), a key second messenger and biosynthetic building block. Although an orthologous bacterial Streptomyces sp. strain PMF PLD structure was solved two decades ago, the molecular basis underlying the functions of the human PLD enzymes (hPLD) remained unclear based on this structure due to the low homology between these sequences. Here, we describe the first crystal structures of hPLD1 and hPLD2 catalytic domains and identify novel structural elements and functional differences between the prokaryotic and eukaryotic enzymes. Furthermore, structure-based mutation studies and structures of inhibitor-hPLD complexes allowed us to elucidate the binding modes of dual and isoform-selective inhibitors, highlight key determinants of isoenzyme selectivity and provide a basis for further structure-based drug discovery and functional characterization of this therapeutically important superfamily of enzymes.

-	~~Authors~~:	+	Human PLD structures enable drug design and characterization of isoenzyme selectivity.,Metrick CM, Peterson EA, Santoro JC, Enyedy IJ, Murugan P, Chen T, Michelsen K, Cullivan M, Spilker KA, Kumar PR, May-Dracka TL, Chodaparambil JV Nat Chem Biol. 2020 Feb 10. pii: 10.1038/s41589-019-0458-4. doi:, 10.1038/s41589-019-0458-4. PMID:32042197<ref>PMID:32042197</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6ohq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Phospholipase D]]
		+	[[Category: Chodaparambil, J V]]
		+	[[Category: Metrick, C M]]
		+	[[Category: Hkd motif]]
		+	[[Category: Hydrolase]]
		+	[[Category: Hydrolase-hydrolase inhibitor complex]]
		+	[[Category: Phosphodiesterase]]

OCA at 05:46, 18 December 2019

2019-12-18T05:46:19Z

←Older revision		Revision as of 05:46, 18 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ohq is ON HOLD	+	The entry 6ohq is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6ohq" [edit=sysop:move=sysop]

2019-04-17T04:10:56Z

Protected "6ohq" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:10, 17 April 2019

OCA: New page: '''Unreleased structure''' The entry 6ohq is ON HOLD Authors: Description: Category: Unreleased Structures

2019-04-17T04:10:55Z

New page: '''Unreleased structure''' The entry 6ohq is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ohq is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]