6p40 - Revision history

OCA at 10:08, 16 August 2023

2023-08-16T10:08:29Z

←Older revision		Revision as of 10:08, 16 August 2023
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	<StructureSection load='6p40' size='340' side='right'caption='[[6p40]], [[Resolution\|resolution]] 2.45Å' scene=''>		<StructureSection load='6p40' size='340' side='right'caption='[[6p40]], [[Resolution\|resolution]] 2.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6p40]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P40 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6P40 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6p40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6P40 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.452Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6p40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p40 OCA], [~~http~~://pdbe.org/6p40 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6p40 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6p40 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6p40 ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6p40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p40 OCA], [https://pdbe.org/6p40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6p40 RCSB], [https://www.ebi.ac.uk/pdbsum/6p40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6p40 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/M1GSK9_MACMU M1GSK9_MACMU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Chen, X J~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: ~~Li, S X~~]]	+	[[Category: Chen XJ]]
-	[[Category: ~~Yang, H J~~]]	+	[[Category: Li SX]]
-	[[Category: ~~Apobec3g]]~~	+	[[Category: Yang HJ]]
-	~~[[Category: Cytidine deaminase]]~~	+
-	~~[[Category: Hiv]]~~	+
-	~~[[Category: Rna binding protein~~]]	+

OCA at 04:18, 13 February 2020

2020-02-13T04:18:39Z

←Older revision		Revision as of 04:18, 13 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6p40 is ~~ON HOLD until Paper~~ Publication	+	==Crystal Structure of Full Length APOBEC3G FKL==
		+	<StructureSection load='6p40' size='340' side='right'caption='[[6p40]], [[Resolution\|resolution]] 2.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6p40]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P40 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P40 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p40 OCA], [http://pdbe.org/6p40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p40 RCSB], [http://www.ebi.ac.uk/pdbsum/6p40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p40 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	APOBEC3G, a member of the double-domain cytidine deaminase (CD) APOBEC, binds RNA to package into virions and restrict HIV-1 through deamination-dependent or deamination-independent inhibition. Mainly due to lack of a full-length double-domain APOBEC structure, it is unknown how CD1/CD2 domains connect and how dimerization/multimerization is linked to RNA binding and virion packaging for HIV-1 restriction. We report rhesus macaque A3G structures that show different inter-domain packing through a short linker and refolding of CD2. The A3G dimer structure has a hydrophobic dimer-interface matching with that of the previously reported CD1 structure. A3G dimerization generates a surface with intensified positive electrostatic potentials (PEP) for RNA binding and dimer stabilization. Unexpectedly, mutating the PEP surface and the hydrophobic interface of A3G does not abolish virion packaging and HIV-1 restriction. The data support a model in which only one RNA-binding mode is critical for virion packaging and restriction of HIV-1 by A3G.

-	~~Authors~~:	+	Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.,Yang H, Ito F, Wolfe AD, Li S, Mohammadzadeh N, Love RP, Yan M, Zirkle B, Gaba A, Chelico L, Chen XS Nat Commun. 2020 Jan 31;11(1):632. doi: 10.1038/s41467-020-14377-y. PMID:32005813<ref>PMID:32005813</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6p40" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chen, X J]]
		+	[[Category: Li, S X]]
		+	[[Category: Yang, H J]]
		+	[[Category: Apobec3g]]
		+	[[Category: Cytidine deaminase]]
		+	[[Category: Hiv]]
		+	[[Category: Rna binding protein]]

OCA at 05:12, 26 June 2019

2019-06-26T05:12:17Z

←Older revision		Revision as of 05:12, 26 June 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6p40 is ON HOLD	+	The entry 6p40 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6p40" [edit=sysop:move=sysop]

2019-06-05T21:11:56Z

Protected "6p40" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:11, 5 June 2019

OCA: New page: '''Unreleased structure''' The entry 6p40 is ON HOLD Authors: Description: Category: Unreleased Structures

2019-06-05T21:11:54Z

New page: '''Unreleased structure''' The entry 6p40 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6p40 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]