6pc1 - Revision history

OCA at 07:26, 11 October 2023

2023-10-11T07:26:47Z

←Older revision		Revision as of 07:26, 11 October 2023
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	<StructureSection load='6pc1' size='340' side='right'caption='[[6pc1]], [[Resolution\|resolution]] 2.76Å' scene=''>		<StructureSection load='6pc1' size='340' side='right'caption='[[6pc1]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pc1]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Helpg Helpg~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PC1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6PC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pc1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_G27 Helicobacter pylori G27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PC1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.76Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPG27_257 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=563041 HELPG])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6pc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pc1 OCA], [~~http~~://pdbe.org/6pc1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pc1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pc1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pc1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pc1 OCA], [https://pdbe.org/6pc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pc1 RCSB], [https://www.ebi.ac.uk/pdbsum/6pc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pc1 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B5ZA44_HELPG B5ZA44_HELPG]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Helpg~~]]	+	[[Category: Helicobacter pylori G27]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ji, X]]	+	[[Category: Ji X]]
-	[[Category: Shaw~~, G X~~]]	+	[[Category: Shaw GX]]
-	[[Category: Song, H]]	+	[[Category: Song H]]
-	[[Category: Wang, C]]	+	[[Category: Wang C]]
-	~~[[Category: Gppa]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Polyphosphate]]~~	+
-	~~[[Category: Ppgpp]]~~	+
-	~~[[Category: Pppgpp]]~~	+
-	~~[[Category: Ppx~~]]	+

OCA at 06:02, 20 May 2020

2020-05-20T06:02:34Z

←Older revision		Revision as of 06:02, 20 May 2020
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	<StructureSection load='6pc1' size='340' side='right'caption='[[6pc1]], [[Resolution\|resolution]] 2.76Å' scene=''>		<StructureSection load='6pc1' size='340' side='right'caption='[[6pc1]], [[Resolution\|resolution]] 2.76Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pc1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PC1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pc1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Helpg Helpg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PC1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PC1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pc1 OCA], [http://pdbe.org/6pc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6pc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pc1 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HPG27_257 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=563041 HELPG])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pc1 OCA], [http://pdbe.org/6pc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6pc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pc1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Helpg]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Ji, X]]		[[Category: Ji, X]]

OCA at 15:30, 20 November 2019

2019-11-20T15:30:13Z

←Older revision		Revision as of 15:30, 20 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6pc1 is ~~ON HOLD~~	+	==Crystal structure of Helicobacter pylori PPX/GppA (E143A) in complex with ppGpp==
		+	<StructureSection load='6pc1' size='340' side='right'caption='[[6pc1]], [[Resolution\|resolution]] 2.76Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6pc1]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PC1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=G4P:GUANOSINE-5,3-TETRAPHOSPHATE'>G4P</scene>, <scene name='pdbligand=LMR:(2S)-2-HYDROXYBUTANEDIOIC+ACID'>LMR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pc1 OCA], [http://pdbe.org/6pc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pc1 RCSB], [http://www.ebi.ac.uk/pdbsum/6pc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pc1 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rapid adaptation to environmental changes is crucial for bacterial survival. Almost all bacteria possess a conserved stringent response system to prompt transcriptional and metabolic responses toward stress. The adaptive process relies on alarmones, guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), to regulate global gene expression. The ppGpp is more potent than pppGpp in the regulatory activity and pppGpp phosphohydrolase (GppA) plays a key role in (p)ppGpp homeostasis. Sharing a similar domain structure, GppA is indistinguishable from exopolyphosphatase (PPX), which mediates the metabolism of cellular inorganic polyphosphate. Here, our phylogenetic analysis of PPX/GppA homologs in bacteria shows a wide distribution with several distinct subfamilies, and our structural and functional analysis of Escherichia coli GppA and Helicobacter pylori PPX/GppA reveals unique properties of each homolog. These results explain how each homolog possesses its distinct functionality.

-	~~Authors~~:	+	Structure and Activity of PPX/GppA Homologs from Escherichia coli and Helicobacter pylori.,Song H, Dharmasena MN, Wang C, Shaw GX, Cherry S, Tropea JE, Jin DJ, Ji X FEBS J. 2019 Nov 2. doi: 10.1111/febs.15120. PMID:31679177<ref>PMID:31679177</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6pc1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ji, X]]
		+	[[Category: Shaw, G X]]
		+	[[Category: Song, H]]
		+	[[Category: Wang, C]]
		+	[[Category: Gppa]]
		+	[[Category: Hydrolase]]
		+	[[Category: Polyphosphate]]
		+	[[Category: Ppgpp]]
		+	[[Category: Pppgpp]]
		+	[[Category: Ppx]]

OCA: Protected "6pc1" [edit=sysop:move=sysop]

2019-06-26T05:15:16Z

Protected "6pc1" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:15, 26 June 2019

OCA: New page: '''Unreleased structure''' The entry 6pc1 is ON HOLD Authors: Description: Category: Unreleased Structures

2019-06-26T05:15:15Z

New page: '''Unreleased structure''' The entry 6pc1 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6pc1 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]