6pxz - Revision history

OCA at 07:37, 11 October 2023

2023-10-11T07:37:51Z

←Older revision		Revision as of 07:37, 11 October 2023
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	<StructureSection load='6pxz' size='340' side='right'caption='[[6pxz]], [[Resolution\|resolution]] 1.70Å' scene=''>		<StructureSection load='6pxz' size='340' side='right'caption='[[6pxz]], [[Resolution\|resolution]] 1.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6pxz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PXZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6PXZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6pxz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PXZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PXZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6pxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pxz OCA], [~~http~~://pdbe.org/6pxz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6pxz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6pxz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6pxz ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pxz OCA], [https://pdbe.org/6pxz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pxz RCSB], [https://www.ebi.ac.uk/pdbsum/6pxz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pxz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SAA3_MOUSE SAA3_MOUSE]] Major acute phase reactant. Apolipoprotein of the HDL complex.	+	[https://www.uniprot.org/uniprot/SAA3_MOUSE SAA3_MOUSE] Major acute phase reactant. Apolipoprotein of the HDL complex.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Serum amyloid A (SAA) proteins are strongly induced in the liver by systemic infection and in the intestine by bacterial colonization. In infected mice, SAA proteins circulate in association with the vitamin A derivative retinol, suggesting that SAAs transport retinol during infection. Here we illuminate a structural basis for the retinol-SAA interaction. In the bloodstream of infected mice, most SAA is complexed with high-density lipoprotein (HDL). However, we found that the majority of the circulating retinol was associated with the small fraction of SAA proteins that circulate without binding to HDL, thus identifying free SAA as the predominant retinol-binding form in vivo. We then determined the crystal structure of retinol-bound mouse SAA3 at a resolution of 2.2 A. Retinol-bound SAA3 formed a novel asymmetric trimeric assembly that was generated by the hydrophobic packing of the conserved amphipathic helices alpha1 and alpha3. This hydrophobic packing created a retinol-binding pocket in the center of the trimer, which was confirmed by mutagenesis studies. Together, these findings illuminate the molecular basis for retinol transport by SAA proteins during infection.
		+
		+	Molecular basis for retinol binding by serum amyloid A during infection.,Hu Z, Bang YJ, Ruhn KA, Hooper LV Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19077-19082. doi: , 10.1073/pnas.1910713116. Epub 2019 Sep 4. PMID:31484771<ref>PMID:31484771</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6pxz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hooper, L V~~]]	+	[[Category: Mus musculus]]
-	[[Category: ~~Hu, Z~~]]	+	[[Category: Hooper LV]]
-	[[Category: ~~Asymmetric]]~~	+	[[Category: Hu Z]]
-	~~[[Category: Retinol binding]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Trimer~~]]	+

OCA at 15:34, 28 August 2019

2019-08-28T15:34:20Z

←Older revision		Revision as of 15:34, 28 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6pxz is ~~ON HOLD~~	+	==Crystal Structure of mouse Serum Amyloid A3 (SAA3) in the trimeric form==
-		+	<StructureSection load='6pxz' size='340' side='right'caption='[[6pxz]], [[Resolution\|resolution]] 1.70Å' scene=''>
-	~~Authors~~: Hu, Z., ~~Hooper~~, L.V.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6pxz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PXZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PXZ FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure~~ of ~~mouse Serum Amyloid A3 (SAA3) in~~ the ~~trimeric form~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMU:DECYL-BETA-D-MALTOPYRANOSIDE'>DMU</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pxz OCA], [http://pdbe.org/6pxz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pxz RCSB], [http://www.ebi.ac.uk/pdbsum/6pxz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pxz ProSAT]</span></td></tr>
-	[[Category: Hooper, L.V]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SAA3_MOUSE SAA3_MOUSE]] Major acute phase reactant. Apolipoprotein of the HDL complex.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hooper, L V]]
	[[Category: Hu, Z]]		[[Category: Hu, Z]]
		+	[[Category: Asymmetric]]
		+	[[Category: Retinol binding]]
		+	[[Category: Transport protein]]
		+	[[Category: Trimer]]

OCA: Protected "6pxz" [edit=sysop:move=sysop]

2019-08-07T04:18:34Z

Protected "6pxz" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 7 August 2019

OCA: New page: '''Unreleased structure''' The entry 6pxz is ON HOLD Authors: Hu, Z., Hooper, L.V. Description: Crystal Structure of mouse Serum Amyloid A3 (SAA3) in the trimeric form [[Category: Unre...

2019-08-07T04:18:32Z

New page: '''Unreleased structure''' The entry 6pxz is ON HOLD Authors: Hu, Z., Hooper, L.V. Description: Crystal Structure of mouse Serum Amyloid A3 (SAA3) in the trimeric form [[Category: Unre...

New page

'''Unreleased structure'''

The entry 6pxz is ON HOLD

Authors: Hu, Z., Hooper, L.V.

Description: Crystal Structure of mouse Serum Amyloid A3 (SAA3) in the trimeric form
[[Category: Unreleased Structures]]
[[Category: Hooper, L.V]]
[[Category: Hu, Z]]