6q64 - Revision history

OCA at 06:21, 12 June 2019

2019-06-12T06:21:07Z

←Older revision		Revision as of 06:21, 12 June 2019
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	<StructureSection load='6q64' size='340' side='right'caption='[[6q64]], [[Resolution\|resolution]] 2.40Å' scene=''>		<StructureSection load='6q64' size='340' side='right'caption='[[6q64]], [[Resolution\|resolution]] 2.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6q64]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q64 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q64 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6q64]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q64 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q64 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BJP75_026240, BSIG_0571, Btheta7330_02659, ERS852430_00349, ERS852511_00641, HMPREF2534_00734 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=818 "Bacillus thetaiotaomicron" Distaso 1912])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q64 OCA], [http://pdbe.org/6q64 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q64 RCSB], [http://www.ebi.ac.uk/pdbsum/6q64 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q64 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q64 OCA], [http://pdbe.org/6q64 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q64 RCSB], [http://www.ebi.ac.uk/pdbsum/6q64 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q64 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Glycans are the major carbon sources available to the human colonic microbiota. Numerous N-glycosylated proteins are found in the human gut, from both dietary and host sources, including immunoglobulins such as IgA that are secreted into the intestine at high levels. Here, we show that many mutualistic gut Bacteroides spp. have the capacity to utilize complex N-glycans (CNGs) as nutrients, including those from immunoglobulins. Detailed mechanistic studies using transcriptomic, biochemical, structural and genetic techniques reveal the pathway employed by Bacteroides thetaiotaomicron (Bt) for CNG degradation. The breakdown process involves an extensive enzymatic apparatus encoded by multiple non-adjacent loci and comprises 19 different carbohydrate-active enzymes from different families, including a CNG-specific endo-glycosidase activity. Furthermore, CNG degradation involves the activity of carbohydrate-active enzymes that have previously been implicated in the degradation of other classes of glycan. This complex and diverse apparatus provides Bt with the capacity to access the myriad different structural variants of CNGs likely to be found in the intestinal niche.
		+
		+	Complex N-glycan breakdown by gut Bacteroides involves an extensive enzymatic apparatus encoded by multiple co-regulated genetic loci.,Briliute J, Urbanowicz PA, Luis AS, Basle A, Paterson N, Rebello O, Hendel J, Ndeh DA, Lowe EC, Martens EC, Spencer DIR, Bolam DN, Crouch LI Nat Microbiol. 2019 Jun 3. pii: 10.1038/s41564-019-0466-x. doi:, 10.1038/s41564-019-0466-x. PMID:31160824<ref>PMID:31160824</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6q64" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus thetaiotaomicron distaso 1912]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Basle, A]]		[[Category: Basle, A]]

OCA at 11:25, 10 May 2019

2019-05-10T11:25:34Z

←Older revision		Revision as of 11:25, 10 May 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6q64 is ~~ON HOLD~~	+	==BT1044SeMet E190Q==
-		+	<StructureSection load='6q64' size='340' side='right'caption='[[6q64]], [[Resolution\|resolution]] 2.40Å' scene=''>
-	~~Authors~~: ~~Basle~~, A., ~~Paterson~~, N., ~~Crouch, L~~., ~~Bolam, D~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6q64]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Q64 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6Q64 FirstGlance]. <br>
-	~~Description: BT1044SeMet E190Q~~	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6q64 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6q64 OCA], [http://pdbe.org/6q64 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6q64 RCSB], [http://www.ebi.ac.uk/pdbsum/6q64 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6q64 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Basle, A]]
	[[Category: Bolam, D]]		[[Category: Bolam, D]]
		+	[[Category: Crouch, L]]
	[[Category: Paterson, N]]		[[Category: Paterson, N]]
-	[[Category: ~~Crouch, L~~]]	+	[[Category: Complex n-glycan]]
-	[[Category: ~~Basle, A~~]]	+	[[Category: Glycoside hydrolase family 18]]
		+	[[Category: Hydrolase]]

OCA: Protected "6q64" [edit=sysop:move=sysop]

2018-12-19T06:45:52Z

Protected "6q64" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:45, 19 December 2018

OCA: New page: '''Unreleased structure''' The entry 6q64 is ON HOLD Authors: Basle, A., Paterson, N., Crouch, L., Bolam, D. Description: BT1044SeMet E190Q Category: Unreleased Structures [[Catego...

2018-12-19T06:45:50Z

New page: '''Unreleased structure''' The entry 6q64 is ON HOLD Authors: Basle, A., Paterson, N., Crouch, L., Bolam, D. Description: BT1044SeMet E190Q Category: Unreleased Structures [[Catego...

New page

'''Unreleased structure'''

The entry 6q64 is ON HOLD

Authors: Basle, A., Paterson, N., Crouch, L., Bolam, D.

Description: BT1044SeMet E190Q
[[Category: Unreleased Structures]]
[[Category: Bolam, D]]
[[Category: Paterson, N]]
[[Category: Crouch, L]]
[[Category: Basle, A]]