6qf4 - Revision history

OCA at 11:58, 24 January 2024

2024-01-24T11:58:51Z

←Older revision		Revision as of 11:58, 24 January 2024
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	<StructureSection load='6qf4' size='340' side='right'caption='[[6qf4]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6qf4' size='340' side='right'caption='[[6qf4]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QF4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QF4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.495Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6qf1\|6qf1]], [[6qf2\|6qf2]], [[6qf3\|6qf3]]</div></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STK17B, DRAK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf4 OCA], [https://pdbe.org/6qf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qf4 RCSB], [https://www.ebi.ac.uk/pdbsum/6qf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf4 OCA], [https://pdbe.org/6qf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qf4 RCSB], [https://www.ebi.ac.uk/pdbsum/6qf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ST17B_HUMAN ST17B_HUMAN]] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.<ref>PMID:9786912</ref>	+	[https://www.uniprot.org/uniprot/ST17B_HUMAN ST17B_HUMAN] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.<ref>PMID:9786912</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Non-specific serine/threonine protein kinase]]~~	+	[[Category: Barthelmess M]]
-	[[Category: Barthelmess, M]]	+	[[Category: Bergtholdt J]]
-	[[Category: Bergtholdt, J]]	+	[[Category: Burkhardt A]]
-	[[Category: Burkhardt, A]]	+	[[Category: Cerv M]]
-	[[Category: Cerv, M]]	+	[[Category: Chapman HN]]
-	[[Category: Chapman~~, H N~~]]	+	[[Category: Crosas E]]
-	[[Category: Crosas, E]]	+	[[Category: Fischer P]]
-	[[Category: Fischer, P]]	+	[[Category: Guenther S]]
-	[[Category: Guenther, S]]	+	[[Category: Kreida S]]
-	[[Category: Kreida, S]]	+	[[Category: Lane TJ]]
-	[[Category: Lane~~, T J~~]]	+	[[Category: Lieske J]]
-	[[Category: Lieske, J]]	+	[[Category: Lorbeer O]]
-	[[Category: Lorbeer, O]]	+	[[Category: Mariani V]]
-	[[Category: Mariani, V]]	+	[[Category: Meents A]]
-	[[Category: Meents, A]]	+	[[Category: Pakendorf T]]
-	[[Category: Pakendorf, T]]	+	[[Category: Ross BH]]
-	[[Category: Ross~~, B H~~]]	+	[[Category: Schoen S]]
-	[[Category: Schoen, S]]	+	[[Category: Seine T]]
-	[[Category: Seine, T]]	+	[[Category: Tornroth-Horsefield S]]
-	[[Category: Tornroth-Horsefield, S]]	+	[[Category: Yefanov O]]
-	[[Category: Yefanov, O]]	+
-	~~[[Category: Adp]]~~	+
-	~~[[Category: Drak2]]~~	+
-	~~[[Category: On-chip ligand soaking]]~~	+
-	~~[[Category: Stk17b]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 11:04, 30 March 2022

2022-03-30T11:04:39Z

←Older revision		Revision as of 11:04, 30 March 2022
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	<StructureSection load='6qf4' size='340' side='right'caption='[[6qf4]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6qf4' size='340' side='right'caption='[[6qf4]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qf4]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF4 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QF4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qf4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QF4 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qf1\|6qf1]], [[6qf2\|6qf2]], [[6qf3\|6qf3]]</td></tr>	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6qf1\|6qf1]], [[6qf2\|6qf2]], [[6qf3\|6qf3]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STK17B, DRAK2 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STK17B, DRAK2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf4 OCA], [~~http~~://pdbe.org/6qf4 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qf4 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qf4 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf4 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf4 OCA], [https://pdbe.org/6qf4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qf4 RCSB], [https://www.ebi.ac.uk/pdbsum/6qf4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf4 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ST17B_HUMAN ST17B_HUMAN]] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.<ref>PMID:9786912</ref>	+	[[https://www.uniprot.org/uniprot/ST17B_HUMAN ST17B_HUMAN]] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.<ref>PMID:9786912</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6qf4" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6qf4" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Serine/threonine protein kinase 3D structures\|Serine/threonine protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:03, 31 July 2019

2019-07-31T07:03:40Z

←Older revision		Revision as of 07:03, 31 July 2019
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	<StructureSection load='6qf4' size='340' side='right'caption='[[6qf4]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='6qf4' size='340' side='right'caption='[[6qf4]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qf4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QF4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qf4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QF4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qf1\|6qf1]], [[6qf2\|6qf2]], [[6qf3\|6qf3]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qf1\|6qf1]], [[6qf2\|6qf2]], [[6qf3\|6qf3]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">STK17B, DRAK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf4 OCA], [http://pdbe.org/6qf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qf4 RCSB], [http://www.ebi.ac.uk/pdbsum/6qf4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf4 OCA], [http://pdbe.org/6qf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qf4 RCSB], [http://www.ebi.ac.uk/pdbsum/6qf4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf4 ProSAT]</span></td></tr>
Line 11:		Line 12:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/ST17B_HUMAN ST17B_HUMAN]] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.<ref>PMID:9786912</ref>		[[http://www.uniprot.org/uniprot/ST17B_HUMAN ST17B_HUMAN]] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.<ref>PMID:9786912</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallography experiments. Compared with other methods, fixed-target sample delivery offers the advantage of significantly reduced sample consumption and shorter data collection times owing to higher hit rates. Here, a new method of on-chip crystallization is reported which allows the efficient and reproducible growth of large numbers of protein crystals directly on micro-patterned silicon chips for in-situ serial crystallography experiments. Crystals are grown by sitting-drop vapor diffusion and previously established crystallization conditions can be directly applied. By reducing the number of crystal-handling steps, the method is particularly well suited for sensitive crystal systems. Excessive mother liquor can be efficiently removed from the crystals by blotting, and no sealing of the fixed-target sample holders is required to prevent the crystals from dehydrating. As a consequence, 'naked' crystals are obtained on the chip, resulting in very low background scattering levels and making the crystals highly accessible for external manipulation such as the application of ligand solutions. Serial diffraction experiments carried out at cryogenic temperatures at a synchrotron and at room temperature at an X-ray free-electron laser yielded high-quality X-ray structures of the human membrane protein aquaporin 2 and two new ligand-bound structures of thermolysin and the human kinase DRAK2. The results highlight the applicability of the method for future high-throughput on-chip screening of pharmaceutical compounds.
		+
		+	On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies.,Lieske J, Cerv M, Kreida S, Komadina D, Fischer J, Barthelmess M, Fischer P, Pakendorf T, Yefanov O, Mariani V, Seine T, Ross BH, Crosas E, Lorbeer O, Burkhardt A, Lane TJ, Guenther S, Bergtholdt J, Schoen S, Tornroth-Horsefield S, Chapman HN, Meents A IUCrJ. 2019 Jun 19;6(Pt 4):714-728. doi: 10.1107/S2052252519007395. eCollection, 2019 Jul 1. PMID:31316815<ref>PMID:31316815</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qf4" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Non-specific serine/threonine protein kinase]]		[[Category: Non-specific serine/threonine protein kinase]]

OCA at 05:54, 10 July 2019

2019-07-10T05:54:12Z

←Older revision		Revision as of 05:54, 10 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qf4 ~~is ON HOLD until Paper Publication~~	+	==X-Ray structure of human Serine/Threonine Kinase 17B (STK17B) aka DRAK2 in complex with ADP obtained by on-chip soaking==
-		+	<StructureSection load='6qf4' size='340' side='right'caption='[[6qf4]], [[Resolution\|resolution]] 2.50Å' scene=''>
-	~~Authors~~: ~~Lieske, J~~.~~, Cerv, M~~.~~, Kreida, S~~.~~, Barthelmess, M~~.~~, Fischer, P~~.~~, Pakendorf, T~~.~~, Yefanov, O~~., ~~Mariani~~, V., ~~Seine~~, T., ~~Ross~~, B.H., ~~Crosas, E~~.~~, Lorbeer, O~~.~~, Burkhardt, A~~.~~, Lane, T~~.J.~~, Guenther, S~~.~~, Bergtholdt, J~~.~~, Schoen, S~~., ~~Tornroth~~-~~Horsefield~~, S., ~~Chapman~~, H.N., ~~Meents, A~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6qf4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QF4 FirstGlance]. <br>
-	~~Description~~: ~~X-Ray structure of human Serine~~/~~Threonine Kinase 17B~~ (~~STK17B~~) ~~aka DRAK2 in complex with ADP obtained by on-chip soaking~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qf1\|6qf1]], [[6qf2\|6qf2]], [[6qf3\|6qf3]]</td></tr>
-	[[Category: ~~Schoen~~, S]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf4 OCA], [http://pdbe.org/6qf4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qf4 RCSB], [http://www.ebi.ac.uk/pdbsum/6qf4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf4 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ST17B_HUMAN ST17B_HUMAN]] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.<ref>PMID:9786912</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Non-specific serine/threonine protein kinase]]
		+	[[Category: Barthelmess, M]]
		+	[[Category: Bergtholdt, J]]
		+	[[Category: Burkhardt, A]]
		+	[[Category: Cerv, M]]
		+	[[Category: Chapman, H N]]
	[[Category: Crosas, E]]		[[Category: Crosas, E]]
		+	[[Category: Fischer, P]]
		+	[[Category: Guenther, S]]
		+	[[Category: Kreida, S]]
		+	[[Category: Lane, T J]]
		+	[[Category: Lieske, J]]
	[[Category: Lorbeer, O]]		[[Category: Lorbeer, O]]
-	[[Category: ~~Kreida~~, S]]	+	[[Category: Mariani, V]]
		+	[[Category: Meents, A]]
		+	[[Category: Pakendorf, T]]
		+	[[Category: Ross, B H]]
		+	[[Category: Schoen, S]]
	[[Category: Seine, T]]		[[Category: Seine, T]]
-	[[Category: Chapman, H.N]]
-	[[Category: Burkhardt, A]]
-	[[Category: Cerv, M]]
	[[Category: Tornroth-Horsefield, S]]		[[Category: Tornroth-Horsefield, S]]
-	[[Category: Pakendorf, T]]
-	[[Category: Ross, B.H]]
	[[Category: Yefanov, O]]		[[Category: Yefanov, O]]
-	[[Category: ~~Bergtholdt, J~~]]	+	[[Category: Adp]]
-	[[Category: ~~Lieske, J~~]]	+	[[Category: Drak2]]
-	[[Category: ~~Lane, T.J~~]]	+	[[Category: On-chip ligand soaking]]
-	[[Category: ~~Fischer, P~~]]	+	[[Category: Stk17b]]
-	[[Category: ~~Meents, A]]~~	+	[[Category: Transferase]]
-	~~[[Category: Mariani, V]]~~	+
-	~~[[Category: Barthelmess, M]]~~	+
-	~~[[Category: Guenther, S~~]]	+

OCA at 06:53, 30 January 2019

2019-01-30T06:53:00Z

←Older revision		Revision as of 06:53, 30 January 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6qf4 is ON HOLD	+	The entry 6qf4 is ON HOLD until Paper Publication

	Authors: Lieske, J., Cerv, M., Kreida, S., Barthelmess, M., Fischer, P., Pakendorf, T., Yefanov, O., Mariani, V., Seine, T., Ross, B.H., Crosas, E., Lorbeer, O., Burkhardt, A., Lane, T.J., Guenther, S., Bergtholdt, J., Schoen, S., Tornroth-Horsefield, S., Chapman, H.N., Meents, A.		Authors: Lieske, J., Cerv, M., Kreida, S., Barthelmess, M., Fischer, P., Pakendorf, T., Yefanov, O., Mariani, V., Seine, T., Ross, B.H., Crosas, E., Lorbeer, O., Burkhardt, A., Lane, T.J., Guenther, S., Bergtholdt, J., Schoen, S., Tornroth-Horsefield, S., Chapman, H.N., Meents, A.

OCA: Protected "6qf4" [edit=sysop:move=sysop]

2019-01-16T10:50:43Z

Protected "6qf4" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:50, 16 January 2019

OCA: New page: '''Unreleased structure''' The entry 6qf4 is ON HOLD Authors: Lieske, J., Cerv, M., Kreida, S., Barthelmess, M., Fischer, P., Pakendorf, T., Yefanov, O., Mariani, V., Seine, T., Ross, B...

2019-01-16T10:50:41Z

New page: '''Unreleased structure''' The entry 6qf4 is ON HOLD Authors: Lieske, J., Cerv, M., Kreida, S., Barthelmess, M., Fischer, P., Pakendorf, T., Yefanov, O., Mariani, V., Seine, T., Ross, B...

New page

'''Unreleased structure'''

The entry 6qf4 is ON HOLD

Authors: Lieske, J., Cerv, M., Kreida, S., Barthelmess, M., Fischer, P., Pakendorf, T., Yefanov, O., Mariani, V., Seine, T., Ross, B.H., Crosas, E., Lorbeer, O., Burkhardt, A., Lane, T.J., Guenther, S., Bergtholdt, J., Schoen, S., Tornroth-Horsefield, S., Chapman, H.N., Meents, A.

Description: X-Ray structure of human Serine/Threonine Kinase 17B (STK17B) aka DRAK2 in complex with ADP obtained by on-chip soaking
[[Category: Unreleased Structures]]
[[Category: Schoen, S]]
[[Category: Crosas, E]]
[[Category: Lorbeer, O]]
[[Category: Kreida, S]]
[[Category: Seine, T]]
[[Category: Chapman, H.N]]
[[Category: Burkhardt, A]]
[[Category: Cerv, M]]
[[Category: Tornroth-Horsefield, S]]
[[Category: Pakendorf, T]]
[[Category: Ross, B.H]]
[[Category: Yefanov, O]]
[[Category: Bergtholdt, J]]
[[Category: Lieske, J]]
[[Category: Lane, T.J]]
[[Category: Fischer, P]]
[[Category: Meents, A]]
[[Category: Mariani, V]]
[[Category: Barthelmess, M]]
[[Category: Guenther, S]]