6qf9 - Revision history

OCA at 11:49, 13 November 2019

2019-11-13T11:49:11Z

←Older revision		Revision as of 11:49, 13 November 2019
Line 3:		Line 3:
	<StructureSection load='6qf9' size='340' side='right'caption='[[6qf9]], [[Resolution\|resolution]] 1.43Å' scene=''>		<StructureSection load='6qf9' size='340' side='right'caption='[[6qf9]], [[Resolution\|resolution]] 1.43Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qf9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QF9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qf9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QF9 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qb3\|6qb3]], [[6qb9\|6qb9]], [[6qf6\|6qf6]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qb3\|6qb3]], [[6qb9\|6qb9]], [[6qf6\|6qf6]]</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf9 OCA], [http://pdbe.org/6qf9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qf9 RCSB], [http://www.ebi.ac.uk/pdbsum/6qf9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf9 OCA], [http://pdbe.org/6qf9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qf9 RCSB], [http://www.ebi.ac.uk/pdbsum/6qf9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf9 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Apoptosis is a crucial process by which multicellular organisms control tissue growth, removal and inflammation. Disruption of the normal apoptotic function is often observed in cancer, where cell death is avoided by the overexpression of anti-apoptotic proteins of the Bcl-2 (B-cell lymphoma 2) family, including Mcl-1 (myeloid cell leukaemia 1). This makes Mcl-1 a potential target for drug therapy, through which normal apoptosis may be restored by inhibiting the protective function of Mcl-1. Here, the discovery and biophysical properties of an anti-Mcl-1 antibody fragment are described and the utility of both the scFv and Fab are demonstrated in generating an Mcl-1 crystal system amenable to iterative structure-guided drug design.
		+
		+	Antibody fragments structurally enable a drug-discovery campaign on the cancer target Mcl-1.,Luptak J, Bista M, Fisher D, Flavell L, Gao N, Wickson K, Kazmirski SL, Howard T, Rawlins PB, Hargreaves D Acta Crystallogr D Struct Biol. 2019 Nov 1;75(Pt 11):1003-1014. doi:, 10.1107/S2059798319014116. Epub 2019 Oct 31. PMID:31692474<ref>PMID:31692474</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6qf9" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==
	*[[Kallikrein 3D structures\|Kallikrein 3D structures]]		*[[Kallikrein 3D structures\|Kallikrein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Luptak, J]]		[[Category: Luptak, J]]

OCA at 06:47, 6 November 2019

2019-11-06T06:47:52Z

←Older revision		Revision as of 06:47, 6 November 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qf9 is ~~ON HOLD~~	+	==Structure of an anti-Mcl1 scFv==
		+	<StructureSection load='6qf9' size='340' side='right'caption='[[6qf9]], [[Resolution\|resolution]] 1.43Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qf9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QF9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QF9 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qb3\|6qb3]], [[6qb9\|6qb9]], [[6qf6\|6qf6]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qf9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qf9 OCA], [http://pdbe.org/6qf9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qf9 RCSB], [http://www.ebi.ac.uk/pdbsum/6qf9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qf9 ProSAT]</span></td></tr>
		+	</table>

-	~~Authors: Luptak, J.~~	+	==See Also==
-		+	*[[Kallikrein 3D structures\|Kallikrein 3D structures]]
-	~~Description: Structure of an anti-Mcl1 scFv~~	+	__TOC__
-	[[Category: ~~Unreleased~~ Structures]]	+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Luptak, J]]		[[Category: Luptak, J]]
		+	[[Category: Apoptosis]]
		+	[[Category: Mcl1]]
		+	[[Category: Scfv]]

OCA: Protected "6qf9" [edit=sysop:move=sysop]

2019-01-16T10:51:03Z

Protected "6qf9" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:51, 16 January 2019

OCA: New page: '''Unreleased structure''' The entry 6qf9 is ON HOLD Authors: Luptak, J. Description: Structure of an anti-Mcl1 scFv Category: Unreleased Structures Category: Luptak, J

2019-01-16T10:51:02Z

New page: '''Unreleased structure''' The entry 6qf9 is ON HOLD Authors: Luptak, J. Description: Structure of an anti-Mcl1 scFv Category: Unreleased Structures Category: Luptak, J

New page

'''Unreleased structure'''

The entry 6qf9 is ON HOLD

Authors: Luptak, J.

Description: Structure of an anti-Mcl1 scFv
[[Category: Unreleased Structures]]
[[Category: Luptak, J]]