OCA at 06:00, 3 July 2019

2019-07-03T06:00:51Z

←Older revision		Revision as of 06:00, 3 July 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6qj0 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of the C. thermophilum condensin Smc2 ATPase head (crystal form II)==
		+	<StructureSection load='6qj0' size='340' side='right'caption='[[6qj0]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qj0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QJ0 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qj0 OCA], [http://pdbe.org/6qj0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qj0 RCSB], [http://www.ebi.ac.uk/pdbsum/6qj0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qj0 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The condensin protein complex plays a key role in the structural organization of genomes. How the ATPase activity of its SMC subunits drives large-scale changes in chromosome topology has remained unknown. Here we reconstruct, at near-atomic resolution, the sequence of events that take place during the condensin ATPase cycle. We show that ATP binding induces a conformational switch in the Smc4 head domain that releases its hitherto undescribed interaction with the Ycs4 HEAT-repeat subunit and promotes its engagement with the Smc2 head into an asymmetric heterodimer. SMC head dimerization subsequently enables nucleotide binding at the second active site and disengages the Brn1 kleisin subunit from the Smc2 coiled coil to open the condensin ring. These large-scale transitions in the condensin architecture lay out a mechanistic path for its ability to extrude DNA helices into large loop structures.

-	~~Authors~~:	+	Structural Basis of an Asymmetric Condensin ATPase Cycle.,Hassler M, Shaltiel IA, Kschonsak M, Simon B, Merkel F, Tharichen L, Bailey HJ, Macosek J, Bravo S, Metz J, Hennig J, Haering CH Mol Cell. 2019 Jun 20;74(6):1175-1188.e9. doi: 10.1016/j.molcel.2019.03.037. PMID:31226277<ref>PMID:31226277</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qj0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Haering, C H]]
		+	[[Category: Hassler, M]]
		+	[[Category: Cell cycle]]
		+	[[Category: Condensin smc complex atpase chromosome condensation loop extrusion]]

OCA: Protected "6qj0" [edit=sysop:move=sysop]

2019-01-30T07:02:01Z

Protected "6qj0" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:02, 30 January 2019

OCA: New page: '''Unreleased structure''' The entry 6qj0 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2019-01-30T07:02:00Z

New page: '''Unreleased structure''' The entry 6qj0 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qj0 is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6qj0 - Revision history

OCA at 06:00, 3 July 2019

OCA: Protected "6qj0" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6qj0 is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures