6ql4 - Revision history

OCA at 08:43, 24 July 2019

2019-07-24T08:43:38Z

←Older revision		Revision as of 08:43, 24 July 2019
Line 3:		Line 3:
	<StructureSection load='6ql4' size='340' side='right'caption='[[6ql4]], [[Resolution\|resolution]] 3.60Å' scene=''>		<StructureSection load='6ql4' size='340' side='right'caption='[[6ql4]], [[Resolution\|resolution]] 3.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ql4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QL4 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ql4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Chatd Chatd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QL4 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0065850 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=759272 CHATD])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ql4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ql4 OCA], [http://pdbe.org/6ql4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ql4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ql4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ql4 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ql4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ql4 OCA], [http://pdbe.org/6ql4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ql4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ql4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ql4 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Balanced fusion and fission are key for the proper function and physiology of mitochondria(1,2). Remodelling of the mitochondrial inner membrane is mediated by the dynamin-like protein mitochondrial genome maintenance 1 (Mgm1) in fungi or the related protein optic atrophy 1 (OPA1) in animals(3-5). Mgm1 is required for the preservation of mitochondrial DNA in yeast(6), whereas mutations in the OPA1 gene in humans are a common cause of autosomal dominant optic atrophy-a genetic disorder that affects the optic nerve(7,8). Mgm1 and OPA1 are present in mitochondria as a membrane-integral long form and a short form that is soluble in the intermembrane space. Yeast strains that express temperature-sensitive mutants of Mgm1(9,10) or mammalian cells that lack OPA1 display fragmented mitochondria(11,12), which suggests that Mgm1 and OPA1 have an important role in inner-membrane fusion. Consistently, only the mitochondrial outer membrane-not the inner membrane-fuses in the absence of functional Mgm1(13). Mgm1 and OPA1 have also been shown to maintain proper cristae architecture(10,14); for example, OPA1 prevents the release of pro-apoptotic factors by tightening crista junctions(15). Finally, the short form of OPA1 localizes to mitochondrial constriction sites, where it presumably promotes mitochondrial fission(16). How Mgm1 and OPA1 perform their diverse functions in membrane fusion, scission and cristae organization is at present unknown. Here we present crystal and electron cryo-tomography structures of Mgm1 from Chaetomium thermophilum. Mgm1 consists of a GTPase (G) domain, a bundle signalling element domain, a stalk, and a paddle domain that contains a membrane-binding site. Biochemical and cell-based experiments demonstrate that the Mgm1 stalk mediates the assembly of bent tetramers into helical filaments. Electron cryo-tomography studies of Mgm1-decorated lipid tubes and fluorescence microscopy experiments on reconstituted membrane tubes indicate how the tetramers assemble on positively or negatively curved membranes. Our findings convey how Mgm1 and OPA1 filaments dynamically remodel the mitochondrial inner membrane.
		+
		+	Structure and assembly of the mitochondrial membrane remodelling GTPase Mgm1.,Faelber K, Dietrich L, Noel JK, Wollweber F, Pfitzner AK, Muhleip A, Sanchez R, Kudryashev M, Chiaruttini N, Lilie H, Schlegel J, Rosenbaum E, Hessenberger M, Matthaeus C, Kunz S, von der Malsburg A, Noe F, Roux A, van der Laan M, Kuhlbrandt W, Daumke O Nature. 2019 Jul;571(7765):429-433. doi: 10.1038/s41586-019-1372-3. Epub 2019 Jul, 10. PMID:31292547<ref>PMID:31292547</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ql4" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chatd]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Chiaruttin, N]]		[[Category: Chiaruttin, N]]

OCA at 06:01, 3 July 2019

2019-07-03T06:01:56Z

←Older revision		Revision as of 06:01, 3 July 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6ql4 ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of nucleotide-free Mgm1==
-		+	<StructureSection load='6ql4' size='340' side='right'caption='[[6ql4]], [[Resolution\|resolution]] 3.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ql4]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QL4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QL4 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ql4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ql4 OCA], [http://pdbe.org/6ql4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ql4 RCSB], [http://www.ebi.ac.uk/pdbsum/6ql4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ql4 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Chiaruttin, N]]
		+	[[Category: Daumke, O]]
		+	[[Category: Dietrich, L]]
		+	[[Category: Faelber, K]]
		+	[[Category: Hessenberger, M]]
		+	[[Category: Kudryashev, M]]
		+	[[Category: Kuehlbrandt, W]]
		+	[[Category: Lilie, H]]
		+	[[Category: Matthaeus, C]]
		+	[[Category: Muehleip, A]]
		+	[[Category: Noe, F]]
		+	[[Category: Noel, J K]]
		+	[[Category: Pfitzner, A K]]
		+	[[Category: Rosenbaum, E]]
		+	[[Category: Roux, A]]
		+	[[Category: Sanchez, R]]
		+	[[Category: Schlegel, J]]
		+	[[Category: Wollweber, F]]
		+	[[Category: VanderLaan, M]]
		+	[[Category: Dynamin superfamily]]
		+	[[Category: Dynamin-like protein]]
		+	[[Category: Membrane remodeling]]
		+	[[Category: Mitochondrial genome maintenance 1 protein]]
		+	[[Category: Mitochondrial inner membrane]]
		+	[[Category: Motor protein]]

OCA at 04:41, 29 May 2019

2019-05-29T04:41:07Z

←Older revision		Revision as of 04:41, 29 May 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ql4 is ON HOLD	+	The entry 6ql4 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 05:18, 21 February 2019

2019-02-21T05:18:51Z

←Older revision		Revision as of 05:18, 21 February 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ql4 is ON HOLD ~~until sometime in the future~~	+	The entry 6ql4 is ON HOLD

	Authors:		Authors:

OCA: Protected "6ql4" [edit=sysop:move=sysop]

2019-02-13T08:02:14Z

Protected "6ql4" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:02, 13 February 2019

OCA: New page: '''Unreleased structure''' The entry 6ql4 is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

2019-02-13T08:02:12Z

New page: '''Unreleased structure''' The entry 6ql4 is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6ql4 is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]