6qta - Revision history

OCA at 12:08, 24 January 2024

2024-01-24T12:08:18Z

←Older revision		Revision as of 12:08, 24 January 2024
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	<StructureSection load='6qta' size='340' side='right'caption='[[6qta]], [[Resolution\|resolution]] 1.89Å' scene=''>		<StructureSection load='6qta' size='340' side='right'caption='[[6qta]], [[Resolution\|resolution]] 1.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qta]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QTA OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QTA FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qta]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QTA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QTA FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.89Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qt8\|6qt8]], [[6qtb\|6qtb]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qta OCA], [~~http~~://pdbe.org/6qta PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qta RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qta PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qta ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qta OCA], [https://pdbe.org/6qta PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qta RCSB], [https://www.ebi.ac.uk/pdbsum/6qta PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qta ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/G0SHE6_CHATD G0SHE6_CHATD]] Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.[PIRNR:PIRNR010340] [[http://www.uniprot.org/uniprot/NLE1_CHATD NLE1_CHATD]] Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin, which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.[UniProtKB:P25382]	+	[https://www.uniprot.org/uniprot/G0SHE6_CHATD G0SHE6_CHATD] Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.[PIRNR:PIRNR010340]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Chaetomium thermophilum var. thermophilum DSM 1495]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ahmed~~, Y L~~]]	+	[[Category: Ahmed YL]]
-	[[Category: Hurt, E]]	+	[[Category: Hurt E]]
-	[[Category: Sinning, I]]	+	[[Category: Sinning I]]
-	[[Category: Thoms, M]]	+	[[Category: Thoms M]]
-	~~[[Category: Integrin]]~~	+
-	~~[[Category: Mida]]~~	+
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Ribosome biogenesis~~]]	+

OCA at 06:02, 7 August 2019

2019-08-07T06:02:37Z

←Older revision		Revision as of 06:02, 7 August 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6qta is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of Rea1-MIDAS/Rsa4-UBL complex from Chaetomium thermophilum==
		+	<StructureSection load='6qta' size='340' side='right'caption='[[6qta]], [[Resolution\|resolution]] 1.89Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qta]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QTA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QTA FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qt8\|6qt8]], [[6qtb\|6qtb]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qta FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qta OCA], [http://pdbe.org/6qta PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qta RCSB], [http://www.ebi.ac.uk/pdbsum/6qta PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qta ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/G0SHE6_CHATD G0SHE6_CHATD]] Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.[PIRNR:PIRNR010340] [[http://www.uniprot.org/uniprot/NLE1_CHATD NLE1_CHATD]] Involved in ribosome biogenesis. Required for processing and efficient intra-nuclear transport of pre-60S ribosomal subunits. Interacts with the AAA-ATPase Midasin, which is essential for the ATP-dependent dissociation of a group of nonribosomal factors from the pre-60S particle.[UniProtKB:P25382]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The Rea1 AAA(+)-ATPase dislodges assembly factors from pre-60S ribosomes upon ATP hydrolysis, thereby driving ribosome biogenesis. Here, we present crystal structures of Rea1-MIDAS, the conserved domain at the tip of the flexible Rea1 tail, alone and in complex with its substrate ligands, the UBL domains of Rsa4 or Ytm1. These complexes have structural similarity to integrin alpha-subunit domains when bound to extracellular matrix ligands, which for integrin biology is a key determinant for force-bearing cell-cell adhesion. However, the presence of additional motifs equips Rea1-MIDAS for its tasks in ribosome maturation. One loop insert cofunctions as an NLS and to activate the mechanochemical Rea1 cycle, whereas an additional beta-hairpin provides an anchor to hold the ligand UBL domains in place. Our data show the versatility of the MIDAS fold for mechanical force transmission in processes as varied as integrin-mediated cell adhesion and mechanochemical removal of assembly factors from pre-ribosomes.

-	~~Authors~~:	+	Crystal structures of Rea1-MIDAS bound to its ribosome assembly factor ligands resembling integrin-ligand-type complexes.,Ahmed YL, Thoms M, Mitterer V, Sinning I, Hurt E Nat Commun. 2019 Jul 11;10(1):3050. doi: 10.1038/s41467-019-10922-6. PMID:31296859<ref>PMID:31296859</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qta" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Ahmed, Y L]]
		+	[[Category: Hurt, E]]
		+	[[Category: Sinning, I]]
		+	[[Category: Thoms, M]]
		+	[[Category: Integrin]]
		+	[[Category: Mida]]
		+	[[Category: Ribosome]]
		+	[[Category: Ribosome biogenesis]]

OCA: Protected "6qta" [edit=sysop:move=sysop]

2019-03-06T05:52:08Z

Protected "6qta" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:52, 6 March 2019

OCA: New page: '''Unreleased structure''' The entry 6qta is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2019-03-06T05:52:06Z

New page: '''Unreleased structure''' The entry 6qta is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6qta is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]