6qxq - Revision history

OCA at 12:10, 24 January 2024

2024-01-24T12:10:40Z

←Older revision		Revision as of 12:10, 24 January 2024
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	<StructureSection load='6qxq' size='340' side='right'caption='[[6qxq]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='6qxq' size='340' side='right'caption='[[6qxq]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qxq]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Myca9 Myca9~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QXQ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6QXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qxq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacteroides_abscessus_ATCC_19977 Mycobacteroides abscessus ATCC 19977]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6QXQ FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=COA:COENZYME+A'>COA</scene>~~, ~~<scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[6qwu\|6qwu]], [[6qxr\|6qxr]], [[6qyf\|6qyf]], [[6qyg\|6qyg]], [[6rcx\|6rcx]]~~<~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<~~tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">MAB_3117c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=561007 MYCA9])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qxq OCA], [https://pdbe.org/6qxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qxq RCSB], [https://www.ebi.ac.uk/pdbsum/6qxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qxq ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6qxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qxq OCA], [~~http~~://pdbe.org/6qxq PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6qxq RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6qxq PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6qxq ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B1MD73_MYCA9 B1MD73_MYCA9]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Myca9~~]]	+	[[Category: Mycobacteroides abscessus ATCC 19977]]
-	[[Category: Mourey, L]]	+	[[Category: Mourey L]]
-	[[Category: Nguyen~~, M C~~]]	+	[[Category: Nguyen MC]]
-	[[Category: Pedelacq~~, J D]]~~	+	[[Category: Pedelacq JD]]
-	~~[[Category: Transferase~~]]	+

OCA at 08:08, 11 November 2020

2020-11-11T08:08:17Z

←Older revision		Revision as of 08:08, 11 November 2020
Line 3:		Line 3:
	<StructureSection load='6qxq' size='340' side='right'caption='[[6qxq]], [[Resolution\|resolution]] 1.45Å' scene=''>		<StructureSection load='6qxq' size='340' side='right'caption='[[6qxq]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6qxq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QXQ OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6QXQ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6qxq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myca9 Myca9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QXQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6QXQ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qwu\|6qwu]], [[6qxr\|6qxr]], [[6qyf\|6qyf]], [[6qyg\|6qyg]], [[6rcx\|6rcx]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qwu\|6qwu]], [[6qxr\|6qxr]], [[6qyf\|6qyf]], [[6qyg\|6qyg]], [[6rcx\|6rcx]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6qxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qxq OCA], [http://pdbe.org/6qxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qxq RCSB], [http://www.ebi.ac.uk/pdbsum/6qxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qxq ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MAB_3117c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=561007 MYCA9])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6qxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qxq OCA], [http://pdbe.org/6qxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qxq RCSB], [http://www.ebi.ac.uk/pdbsum/6qxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qxq ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Myca9]]
	[[Category: Mourey, L]]		[[Category: Mourey, L]]
	[[Category: Nguyen, M C]]		[[Category: Nguyen, M C]]
	[[Category: Pedelacq, J D]]		[[Category: Pedelacq, J D]]
	[[Category: Transferase]]		[[Category: Transferase]]

OCA at 10:15, 27 March 2020

2020-03-27T10:15:29Z

←Older revision		Revision as of 10:15, 27 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6qxq is ~~ON HOLD~~	+	==4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus at pH 7 with Mn2+ and CoA.==
		+	<StructureSection load='6qxq' size='340' side='right'caption='[[6qxq]], [[Resolution\|resolution]] 1.45Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6qxq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QXQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QXQ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6qwu\|6qwu]], [[6qxr\|6qxr]], [[6qyf\|6qyf]], [[6qyg\|6qyg]], [[6rcx\|6rcx]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qxq OCA], [http://pdbe.org/6qxq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qxq RCSB], [http://www.ebi.ac.uk/pdbsum/6qxq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qxq ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	One central question surrounding the biosynthesis of fatty acids and polyketide-derived natural products is how the 4'-phosphopantetheinyl transferase (PPTase) interrogates the essential acyl carrier protein (ACP) domain to fulfill the initial activation step. The triggering factor of this study was the lack of structural information on PPTases at physiological pH, which could bias our comprehension of the mechanism of action of these important enzymes. Structural and functional studies on the family II PPTase PptAb of Mycobacterium abscessus show that pH has a profound effect on the coordination of metal ions and on the conformation of endogenously bound coenzyme A (CoA). The observed conformational flexibility of CoA at physiological pH is accompanied by a disordered 4'-phosphopantetheine (Ppant) moiety. Finally, structural and dynamical information on an isolated mycobacterial ACP domain, in its apo form and in complex with the activator PptAb, suggests an alternate mechanism for the post-translational modification of modular megasynthases.

-	~~Authors:~~ Nguyen, M.C., ~~Mourey~~, L., Pedelacq, J.D.	+	Conformational flexibility of coenzyme A and its impact on the post-translational modification of acyl carrier proteins by 4'-phosphopantetheinyl transferases.,Nguyen MC, Saurel O, Carivenc C, Gavalda S, Saitta S, Tran MP, Milon A, Chalut C, Guilhot C, Mourey L, Pedelacq JD FEBS J. 2020 Mar 3. doi: 10.1111/febs.15273. PMID:32128972<ref>PMID:32128972</ref>

-	~~Description: 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus at pH 7 with Mn2+ and CoA~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6qxq" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Mourey, L]]		[[Category: Mourey, L]]
-	[[Category: Nguyen, M.C]]	+	[[Category: Nguyen, M C]]
-	[[Category: Pedelacq, J.D]]	+	[[Category: Pedelacq, J D]]
		+	[[Category: Transferase]]

OCA: Protected "6qxq" [edit=sysop:move=sysop]

2019-03-13T10:32:31Z

Protected "6qxq" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:32, 13 March 2019

OCA: New page: '''Unreleased structure''' The entry 6qxq is ON HOLD Authors: Nguyen, M.C., Mourey, L., Pedelacq, J.D. Description: 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessu...

2019-03-13T10:32:30Z

New page: '''Unreleased structure''' The entry 6qxq is ON HOLD Authors: Nguyen, M.C., Mourey, L., Pedelacq, J.D. Description: 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessu...

New page

'''Unreleased structure'''

The entry 6qxq is ON HOLD

Authors: Nguyen, M.C., Mourey, L., Pedelacq, J.D.

Description: 4'-phosphopantetheinyl transferase PptAb from Mycobacterium abscessus at pH 7 with Mn2+ and CoA.
[[Category: Unreleased Structures]]
[[Category: Mourey, L]]
[[Category: Nguyen, M.C]]
[[Category: Pedelacq, J.D]]