6rp5 - Revision history

OCA at 12:25, 24 January 2024

2024-01-24T12:25:29Z

←Older revision		Revision as of 12:25, 24 January 2024
Line 3:		Line 3:
	<StructureSection load='6rp5' size='340' side='right'caption='[[6rp5]], [[Resolution\|resolution]] 1.49Å' scene=''>		<StructureSection load='6rp5' size='340' side='right'caption='[[6rp5]], [[Resolution\|resolution]] 1.49Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rp5]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Eleginops_maclovinus Eleginops maclovinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RP5 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RP5 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rp5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Eleginops_maclovinus Eleginops maclovinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RP5 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=DTN:DITHIONITE'>DTN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4~~</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.49Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE~~</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=DTN:DITHIONITE'>DTN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rp5 OCA], [~~http~~://pdbe.org/6rp5 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rp5 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rp5 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rp5 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rp5 OCA], [https://pdbe.org/6rp5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rp5 RCSB], [https://www.ebi.ac.uk/pdbsum/6rp5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rp5 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HBA1_ELEMC HBA1_ELEMC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6rp5" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rp5" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemoglobin 3D structures\|Hemoglobin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 23:		Line 28:
	[[Category: Eleginops maclovinus]]		[[Category: Eleginops maclovinus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Balasco, N]]	+	[[Category: Balasco N]]
-	[[Category: Mazzarella, L]]	+	[[Category: Mazzarella L]]
-	[[Category: Merlino, A]]	+	[[Category: Merlino A]]
-	[[Category: Verde, C]]	+	[[Category: Verde C]]
-	[[Category: Vergara, A]]	+	[[Category: Vergara A]]
-	[[Category: Vitagliano, L]]	+	[[Category: Vitagliano L]]
-	~~[[Category: Hemoglobin]]~~	+
-	~~[[Category: Oxygen transport]]~~	+
-	~~[[Category: Sub-antarctic fish~~]]	+

OCA at 09:15, 25 December 2019

2019-12-25T09:15:54Z

←Older revision		Revision as of 09:15, 25 December 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rp5 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of monocarboxylated hemoglobin from the sub-Antarctic fish Eleginops maclovinus==
		+	<StructureSection load='6rp5' size='340' side='right'caption='[[6rp5]], [[Resolution\|resolution]] 1.49Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rp5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eleginops_maclovinus Eleginops maclovinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RP5 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=DTN:DITHIONITE'>DTN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rp5 OCA], [http://pdbe.org/6rp5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rp5 RCSB], [http://www.ebi.ac.uk/pdbsum/6rp5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rp5 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Tetrameric hemoglobins (Hbs) are prototypical systems for the investigations of fundamental properties of proteins. Although the structure of these proteins has been known for nearly sixty years, there are many aspects related to their function/structure that are still obscure. Here, we report the crystal structure of a carbonmonoxy form of the Hb isolated from the sub-Antarctic notothenioid fish Eleginops maclovinus characterised by either rare or unique features. In particular, the distal site of the alpha chain results to be very unusual since the distal His is displaced from its canonical position. This displacement is coupled with a shortening of the highly conserved E helix and the formation of novel interactions at tertiary structure level. Interestingly, the quaternary structure is closer to the T-deoxy state of Hbs than to the R-state despite the full coordination of all chains. Notably, these peculiar structural features provide a rationale for some spectroscopic properties exhibited by the protein in solution. Finally, this unexpected structural plasticity of the heme distal side has been associated with specific sequence signatures of various Hbs.

-	~~Authors: Balasco~~, N., Vitagliano, L., Merlino, A., Verde, C., Mazzarella, L., Vergara, A.	+	The unique structural features of carbonmonoxy hemoglobin from the sub-Antarctic fish Eleginops maclovinus.,Balasco N, Vitagliano L, Merlino A, Verde C, Mazzarella L, Vergara A Sci Rep. 2019 Dec 12;9(1):18987. doi: 10.1038/s41598-019-55331-3. PMID:31831781<ref>PMID:31831781</ref>

-	~~Description: Crystal structure~~ of ~~monocarboxylated hemoglobin from~~ the ~~sub~~-~~Antarctic fish~~ Eleginops maclovinus	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6rp5" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Eleginops maclovinus]]
		+	[[Category: Large Structures]]
	[[Category: Balasco, N]]		[[Category: Balasco, N]]
	[[Category: Mazzarella, L]]		[[Category: Mazzarella, L]]
-	[[Category: Vitagliano, L]]
-	[[Category: Vergara, A]]
	[[Category: Merlino, A]]		[[Category: Merlino, A]]
	[[Category: Verde, C]]		[[Category: Verde, C]]
		+	[[Category: Vergara, A]]
		+	[[Category: Vitagliano, L]]
		+	[[Category: Hemoglobin]]
		+	[[Category: Oxygen transport]]
		+	[[Category: Sub-antarctic fish]]

OCA: Protected "6rp5" [edit=sysop:move=sysop]

2019-05-22T04:18:28Z

Protected "6rp5" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:18, 22 May 2019

OCA: New page: '''Unreleased structure''' The entry 6rp5 is ON HOLD until Paper Publication Authors: Balasco, N., Vitagliano, L., Merlino, A., Verde, C., Mazzarella, L., Vergara, A. Description: Crys...

2019-05-22T04:18:26Z

New page: '''Unreleased structure''' The entry 6rp5 is ON HOLD until Paper Publication Authors: Balasco, N., Vitagliano, L., Merlino, A., Verde, C., Mazzarella, L., Vergara, A. Description: Crys...

New page

'''Unreleased structure'''

The entry 6rp5 is ON HOLD until Paper Publication

Authors: Balasco, N., Vitagliano, L., Merlino, A., Verde, C., Mazzarella, L., Vergara, A.

Description: Crystal structure of monocarboxylated hemoglobin from the sub-Antarctic fish Eleginops maclovinus
[[Category: Unreleased Structures]]
[[Category: Balasco, N]]
[[Category: Mazzarella, L]]
[[Category: Vitagliano, L]]
[[Category: Vergara, A]]
[[Category: Merlino, A]]
[[Category: Verde, C]]