6rxu - Revision history

OCA at 10:13, 22 May 2024

2024-05-22T10:13:38Z

←Older revision		Revision as of 10:13, 22 May 2024
Line 3:		Line 3:
	<SX load='6rxu' size='340' side='right' viewer='molstar' caption='[[6rxu]], [[Resolution\|resolution]] 3.50Å' scene=''>		<SX load='6rxu' size='340' side='right' viewer='molstar' caption='[[6rxu]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rxu]] is a 66 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6RXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rxu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RXU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 3.5Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6rxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxu OCA], [~~http~~://pdbe.org/6rxu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6rxu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6rxu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxu ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxu OCA], [https://pdbe.org/6rxu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rxu RCSB], [https://www.ebi.ac.uk/pdbsum/6rxu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/G0S3V7_CHATD G0S3V7_CHATD]] Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[PIRNR:PIRNR006515] [[http://www.uniprot.org/uniprot/PNO1_CHATD PNO1_CHATD]] Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.[UniProtKB:Q99216] [[http://www.uniprot.org/uniprot/UTP11_CHATD UTP11_CHATD]] Involved in nucleolar processing of pre-18S ribosomal RNA.[UniProtKB:P34247] [[http://www.uniprot.org/uniprot/NOL10_CHATD NOL10_CHATD]] May be involved in rRNA-processing and ribosome biosynthesis.[UniProtKB:P48234]	+	[https://www.uniprot.org/uniprot/G0SBN9_CHATD G0SBN9_CHATD]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 22:
	==See Also==		==See Also==
	*[[Ribosome 3D structures\|Ribosome 3D structures]]		*[[Ribosome 3D structures\|Ribosome 3D structures]]
		+	*[[Ribosome biogenesis protein 3D structures\|Ribosome biogenesis protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 27:		Line 29:
	[[Category: Chaetomium thermophilum]]		[[Category: Chaetomium thermophilum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Beckmann, R]]	+	[[Category: Beckmann R]]
-	[[Category: Berninghausen, O]]	+	[[Category: Berninghausen O]]
-	[[Category: Cheng, J]]	+	[[Category: Cheng J]]
-	[[Category: Griesel, S]]	+	[[Category: Griesel S]]
-	[[Category: Hurt, E]]	+	[[Category: Hurt E]]
-	[[Category: Kellner, N]]	+	[[Category: Kellner N]]
-	~~[[Category: Ribosome]]~~	+
-	~~[[Category: Ribosome biogenesis]]~~	+
-	~~[[Category: Rrna~~]]	+

OCA at 05:55, 11 April 2020

2020-04-11T05:55:39Z

←Older revision		Revision as of 05:55, 11 April 2020
Line 3:		Line 3:
	<SX load='6rxu' size='340' side='right' viewer='molstar' caption='[[6rxu]], [[Resolution\|resolution]] 3.50Å' scene=''>		<SX load='6rxu' size='340' side='right' viewer='molstar' caption='[[6rxu]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6rxu]] is a 66 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6RXU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6rxu]] is a 66 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6RXU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6rxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxu OCA], [http://pdbe.org/6rxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rxu RCSB], [http://www.ebi.ac.uk/pdbsum/6rxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6rxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxu OCA], [http://pdbe.org/6rxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rxu RCSB], [http://www.ebi.ac.uk/pdbsum/6rxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[http://www.uniprot.org/uniprot/G0S3V7_CHATD G0S3V7_CHATD]] Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[PIRNR:PIRNR006515] [[http://www.uniprot.org/uniprot/PNO1_CHATD PNO1_CHATD]] Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.[UniProtKB:Q99216] [[http://www.uniprot.org/uniprot/~~NOL10_CHATD NOL10_CHATD~~]] ~~May be involved~~ in ~~rRNA-~~processing ~~and ribosome biosynthesis~~.[UniProtKB:~~P48234~~] [[http://www.uniprot.org/uniprot/~~UTP11_CHATD UTP11_CHATD~~]] ~~Involved~~ in ~~nucleolar processing of pre~~-~~18S ribosomal RNA~~.[UniProtKB:~~P34247~~]	+	[[http://www.uniprot.org/uniprot/G0S3V7_CHATD G0S3V7_CHATD]] Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[PIRNR:PIRNR006515] [[http://www.uniprot.org/uniprot/PNO1_CHATD PNO1_CHATD]] Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.[UniProtKB:Q99216] [[http://www.uniprot.org/uniprot/UTP11_CHATD UTP11_CHATD]] Involved in nucleolar processing of pre-18S ribosomal RNA.[UniProtKB:P34247] [[http://www.uniprot.org/uniprot/NOL10_CHATD NOL10_CHATD]] May be involved in rRNA-processing and ribosome biosynthesis.[UniProtKB:P48234]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 00:28, 7 March 2020

2020-03-07T00:28:00Z

←Older revision		Revision as of 00:28, 7 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B1==		==Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B1==
-	<~~StructureSection~~ load='6rxu' size='340' side='right'caption='[[6rxu]], [[Resolution\|resolution]] 3.50Å' scene=''>	+	<SX load='6rxu' size='340' side='right' viewer='molstar' caption='[[6rxu]], [[Resolution\|resolution]] 3.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6rxu]] is a 66 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RXU FirstGlance]. <br>		<table><tr><td colspan='2'>[[6rxu]] is a 66 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RXU FirstGlance]. <br>
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 6rxu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6rxu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ribosome 3D structures\|Ribosome 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Chaetomium thermophilum]]		[[Category: Chaetomium thermophilum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 16:47, 14 August 2019

2019-08-14T16:47:07Z

←Older revision		Revision as of 16:47, 14 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6rxu is ~~ON HOLD~~	+	==Cryo-EM structure of the 90S pre-ribosome (Kre33-Noc4) from Chaetomium thermophilum, state B1==
		+	<StructureSection load='6rxu' size='340' side='right'caption='[[6rxu]], [[Resolution\|resolution]] 3.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6rxu]] is a 66 chain structure with sequence from [http://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RXU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RXU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rxu OCA], [http://pdbe.org/6rxu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rxu RCSB], [http://www.ebi.ac.uk/pdbsum/6rxu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rxu ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/G0S3V7_CHATD G0S3V7_CHATD]] Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.[PIRNR:PIRNR006515] [[http://www.uniprot.org/uniprot/PNO1_CHATD PNO1_CHATD]] Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.[UniProtKB:Q99216] [[http://www.uniprot.org/uniprot/NOL10_CHATD NOL10_CHATD]] May be involved in rRNA-processing and ribosome biosynthesis.[UniProtKB:P48234] [[http://www.uniprot.org/uniprot/UTP11_CHATD UTP11_CHATD]] Involved in nucleolar processing of pre-18S ribosomal RNA.[UniProtKB:P34247]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Eukaryotic ribosome biogenesis involves RNA folding and processing that depend on assembly factors and small nucleolar RNAs (snoRNAs). The 90S (SSU-processome) is the earliest pre-ribosome structurally analyzed, which was suggested to assemble stepwise along the growing pre-rRNA from 5' > 3', but this directionality may not be accurate. Here, by analyzing the structure of a series of 90S assembly intermediates from Chaetomium thermophilum, we discover a reverse order of 18S rRNA subdomain incorporation. Large parts of the 18S rRNA 3' and central domains assemble first into the 90S before the 5' domain is integrated. This final incorporation depends on a contact between a heterotrimer Enp2-Bfr2-Lcp5 recruited to the flexible 5' domain and Kre33, which reconstitutes the Kre33-Enp-Brf2-Lcp5 module on the compacted 90S. Keeping the 5' domain temporarily segregated from the 90S scaffold could provide extra time to complete the multifaceted 5' domain folding, which depends on a distinct set of snoRNAs and processing factors.

-	~~Authors~~:	+	Thermophile 90S Pre-ribosome Structures Reveal the Reverse Order of Co-transcriptional 18S rRNA Subdomain Integration.,Cheng J, Bassler J, Fischer P, Lau B, Kellner N, Kunze R, Griesel S, Kallas M, Berninghausen O, Strauss D, Beckmann R, Hurt E Mol Cell. 2019 Jul 15. pii: S1097-2765(19)30489-7. doi:, 10.1016/j.molcel.2019.06.032. PMID:31378463<ref>PMID:31378463</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6rxu" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chaetomium thermophilum]]
		+	[[Category: Large Structures]]
		+	[[Category: Beckmann, R]]
		+	[[Category: Berninghausen, O]]
		+	[[Category: Cheng, J]]
		+	[[Category: Griesel, S]]
		+	[[Category: Hurt, E]]
		+	[[Category: Kellner, N]]
		+	[[Category: Ribosome]]
		+	[[Category: Ribosome biogenesis]]
		+	[[Category: Rrna]]

OCA: Protected "6rxu" [edit=sysop:move=sysop]

2019-06-19T04:30:30Z

Protected "6rxu" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:30, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6rxu is ON HOLD Authors: Description: Category: Unreleased Structures

2019-06-19T04:30:29Z

New page: '''Unreleased structure''' The entry 6rxu is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6rxu is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]