6s06 - Revision history

OCA at 12:32, 24 January 2024

2024-01-24T12:32:16Z

←Older revision		Revision as of 12:32, 24 January 2024
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	==Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26==		==Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26==
-	<StructureSection load='6s06' size='340' side='right'caption='[[6s06]]' scene=''>	+	<StructureSection load='6s06' size='340' side='right'caption='[[6s06]], [[Resolution\|resolution]] 1.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S06 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s06]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sphingobium_japonicum_UT26S Sphingobium japonicum UT26S]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S06 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s06 OCA], [https://pdbe.org/6s06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s06 RCSB], [https://www.ebi.ac.uk/pdbsum/6s06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s06 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.15Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s06 OCA], [https://pdbe.org/6s06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s06 RCSB], [https://www.ebi.ac.uk/pdbsum/6s06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s06 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/LINB_SPHJU LINB_SPHJU] Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons. Has a broad substrate specificity since not only monochloroalkanes (C3 to C10) but also dichloroalkanes (> C3), bromoalkanes, and chlorinated aliphatic alcohols are good substrates (PubMed:9293022, PubMed:10100638). Shows almost no activity with 1,2-dichloroethane, but very high activity with the brominated analog (PubMed:9293022). Is involved in the degradation of the important environmental pollutant gamma-hexachlorocyclohexane (gamma-HCH or lindane) as it also catalyzes conversion of 1,3,4,6-tetrachloro-1,4-cyclohexadiene (1,4-TCDN) to 2,5-dichloro-2,5-cyclohexadiene-1,4-diol (2,5-DDOL) via the intermediate 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (2,4,5-DNOL) (PubMed:7691794). This degradation pathway allows S.japonicum UT26 to grow on gamma-HCH as the sole source of carbon and energy.<ref>PMID:10100638</ref> <ref>PMID:7691794</ref> <ref>PMID:9293022</ref>
		+
		+	==See Also==
		+	*[[Dehalogenase 3D structures\|Dehalogenase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
		+	[[Category: Sphingobium japonicum UT26S]]
	[[Category: Chaloupkova R]]		[[Category: Chaloupkova R]]
	[[Category: Degtjarik O]]		[[Category: Degtjarik O]]

OCA at 08:00, 27 January 2021

2021-01-27T08:00:51Z

←Older revision		Revision as of 08:00, 27 January 2021
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-	'''Unreleased structure'''

-	~~The entry 6s06 is ON HOLD until Paper Publication~~	+	==Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26==
-		+	<StructureSection load='6s06' size='340' side='right'caption='[[6s06]]' scene=''>
-	~~Authors: Iermak, I., Mesters, J.R., Degtjarik, O., Chaloupkova, R., Kuta Smatanova, I.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S06 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s06 OCA], [https://pdbe.org/6s06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s06 RCSB], [https://www.ebi.ac.uk/pdbsum/6s06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s06 ProSAT]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[[~~Category~~: ~~Mesters~~, J.R]]	+	__TOC__
-	[[Category: ~~Iermak, I~~]]	+	</StructureSection>
-	[[Category: Degtjarik, O]]	+	[[Category: Large Structures]]
-	[[Category: Kuta Smatanova, I]]	+	[[Category: Chaloupkova R]]
-	[[Category: ~~Chaloupkova, R~~]]	+	[[Category: Degtjarik O]]
		+	[[Category: Iermak I]]
		+	[[Category: Kuta Smatanova I]]
		+	[[Category: Mesters JR]]

OCA at 05:25, 26 June 2019

2019-06-26T05:25:11Z

←Older revision		Revision as of 05:25, 26 June 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6s06 is ON HOLD	+	The entry 6s06 is ON HOLD until Paper Publication

	Authors: Iermak, I., Mesters, J.R., Degtjarik, O., Chaloupkova, R., Kuta Smatanova, I.		Authors: Iermak, I., Mesters, J.R., Degtjarik, O., Chaloupkova, R., Kuta Smatanova, I.
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	[[Category: Mesters, J.R]]		[[Category: Mesters, J.R]]
	[[Category: Iermak, I]]		[[Category: Iermak, I]]
-	[[Category: Kuta Smatanova, I]]
	[[Category: Degtjarik, O]]		[[Category: Degtjarik, O]]
		+	[[Category: Kuta Smatanova, I]]
	[[Category: Chaloupkova, R]]		[[Category: Chaloupkova, R]]

OCA: Protected "6s06" [edit=sysop:move=sysop]

2019-06-19T04:36:41Z

Protected "6s06" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:36, 19 June 2019

OCA: New page: '''Unreleased structure''' The entry 6s06 is ON HOLD Authors: Iermak, I., Mesters, J.R., Degtjarik, O., Chaloupkova, R., Kuta Smatanova, I. Description: Crystal structure of haloalkane...

2019-06-19T04:36:40Z

New page: '''Unreleased structure''' The entry 6s06 is ON HOLD Authors: Iermak, I., Mesters, J.R., Degtjarik, O., Chaloupkova, R., Kuta Smatanova, I. Description: Crystal structure of haloalkane...

New page

'''Unreleased structure'''

The entry 6s06 is ON HOLD

Authors: Iermak, I., Mesters, J.R., Degtjarik, O., Chaloupkova, R., Kuta Smatanova, I.

Description: Crystal structure of haloalkane dehalogenase LinB D147C+L177C mutant (LinB73) from Sphingobium japonicum UT26
[[Category: Unreleased Structures]]
[[Category: Mesters, J.R]]
[[Category: Iermak, I]]
[[Category: Kuta Smatanova, I]]
[[Category: Degtjarik, O]]
[[Category: Chaloupkova, R]]