6s7v - Revision history

OCA at 05:51, 13 May 2020

2020-05-13T05:51:43Z

←Older revision		Revision as of 05:51, 13 May 2020
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	==Lipoteichoic acids flippase LtaA==		==Lipoteichoic acids flippase LtaA==
-	<StructureSection load='6s7v' size='340' side='right'caption='[[6s7v]]' scene=''>	+	<StructureSection load='6s7v' size='340' side='right'caption='[[6s7v]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S7V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S7V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6s7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S7V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S7V FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s7v OCA], [http://pdbe.org/6s7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s7v RCSB], [http://www.ebi.ac.uk/pdbsum/6s7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s7v ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BTN44_07740, FA040_03480, RK64_05390 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s7v OCA], [http://pdbe.org/6s7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s7v RCSB], [http://www.ebi.ac.uk/pdbsum/6s7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s7v ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Lipoteichoic acids (LTAs) are essential cell-wall components in Gram-positive bacteria, including the human pathogen Staphylococcus aureus, contributing to cell adhesion, cell division and antibiotic resistance. Genetic evidence has suggested that LtaA is the flippase that mediates the translocation of the lipid-linked disaccharide that anchors LTA to the cell membrane, a rate-limiting step in S. aureus LTA biogenesis. Here, we present the structure of LtaA, describe its flipping mechanism and show its functional relevance for S. aureus fitness. We demonstrate that LtaA is a proton-coupled antiporter flippase that contributes to S. aureus survival under physiological acidic conditions. Our results provide foundations for the development of new strategies to counteract S. aureus infections.
		+
		+	Structure of a proton-dependent lipid transporter involved in lipoteichoic acids biosynthesis.,Zhang B, Liu X, Lambert E, Mas G, Hiller S, Veening JW, Perez C Nat Struct Mol Biol. 2020 May 4. pii: 10.1038/s41594-020-0425-5. doi:, 10.1038/s41594-020-0425-5. PMID:32367070<ref>PMID:32367070</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6s7v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Perez C]]	+	[[Category: Perez, C]]
-	[[Category: Zhang B]]	+	[[Category: Zhang, B]]
		+	[[Category: Flippase]]
		+	[[Category: Lipoteichoic acid]]
		+	[[Category: Transport protein]]

OCA at 05:42, 22 April 2020

2020-04-22T05:42:41Z

←Older revision		Revision as of 05:42, 22 April 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6s7v ~~is ON HOLD until Paper Publication~~	+	==Lipoteichoic acids flippase LtaA==
-		+	<StructureSection load='6s7v' size='340' side='right'caption='[[6s7v]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S7V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S7V FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s7v OCA], [http://pdbe.org/6s7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s7v RCSB], [http://www.ebi.ac.uk/pdbsum/6s7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s7v ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Perez C]]
		+	[[Category: Zhang B]]

OCA at 06:22, 4 December 2019

2019-12-04T06:22:17Z

←Older revision		Revision as of 06:22, 4 December 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6s7v is ON HOLD	+	The entry 6s7v is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6s7v" [edit=sysop:move=sysop]

2019-07-17T09:15:55Z

Protected "6s7v" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:15, 17 July 2019

OCA: New page: '''Unreleased structure''' The entry 6s7v is ON HOLD Authors: Description: Category: Unreleased Structures

2019-07-17T09:15:53Z

New page: '''Unreleased structure''' The entry 6s7v is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6s7v is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]