6sey - Revision history

OCA at 12:40, 24 January 2024

2024-01-24T12:40:57Z

←Older revision		Revision as of 12:40, 24 January 2024
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	==Human Carbonic Anhydrase II in complex with aliphatically substituted benzenesulfonamide==		==Human Carbonic Anhydrase II in complex with aliphatically substituted benzenesulfonamide==
-	<StructureSection load='6sey' size='340' side='right'caption='[[6sey]]' scene=''>	+	<StructureSection load='6sey' size='340' side='right'caption='[[6sey]], [[Resolution\|resolution]] 1.23Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SEY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SEY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sey]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SEY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SEY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6sey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sey OCA], [~~http~~://pdbe.org/6sey PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sey RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sey PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sey ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.23Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BE7:(4-CARBOXYPHENYL)(CHLORO)MERCURY'>BE7</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=L9B:4-(4-oxidanylbutyl)benzenesulfonamide'>L9B</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sey OCA], [https://pdbe.org/6sey PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sey RCSB], [https://www.ebi.ac.uk/pdbsum/6sey PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sey ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gloeckner S]]		[[Category: Gloeckner S]]

OCA at 11:13, 26 August 2020

2020-08-26T11:13:41Z

←Older revision		Revision as of 11:13, 26 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6sey ~~is ON HOLD until Paper Publication~~	+	==Human Carbonic Anhydrase II in complex with aliphatically substituted benzenesulfonamide==
-		+	<StructureSection load='6sey' size='340' side='right'caption='[[6sey]]' scene=''>
-	~~Authors~~: ~~Gloeckner~~, S., ~~Ngo~~, K., ~~Heine, A~~., ~~Klebe, G~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SEY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SEY FirstGlance]. <br>
-	~~Description: Human Carbonic Anhydrase II in complex with aliphatically substituted benzenesulfonamide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sey FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sey OCA], [http://pdbe.org/6sey PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sey RCSB], [http://www.ebi.ac.uk/pdbsum/6sey PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sey ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: ~~Ngo, K~~]]	+	__TOC__
-	[[Category: ~~Gloeckner, S~~]]	+	</StructureSection>
-	[[Category: ~~Heine, A~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Klebe, G~~]]	+	[[Category: Gloeckner S]]
		+	[[Category: Heine A]]
		+	[[Category: Klebe G]]
		+	[[Category: Ngo K]]

OCA: Protected "6sey" [edit=sysop:move=sysop]

2019-08-07T04:33:09Z

Protected "6sey" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:33, 7 August 2019

OCA: New page: '''Unreleased structure''' The entry 6sey is ON HOLD until Paper Publication Authors: Gloeckner, S., Ngo, K., Heine, A., Klebe, G. Description: Human Carbonic Anhydrase II in complex w...

2019-08-07T04:33:08Z

New page: '''Unreleased structure''' The entry 6sey is ON HOLD until Paper Publication Authors: Gloeckner, S., Ngo, K., Heine, A., Klebe, G. Description: Human Carbonic Anhydrase II in complex w...

New page

'''Unreleased structure'''

The entry 6sey is ON HOLD until Paper Publication

Authors: Gloeckner, S., Ngo, K., Heine, A., Klebe, G.

Description: Human Carbonic Anhydrase II in complex with aliphatically substituted benzenesulfonamide
[[Category: Unreleased Structures]]
[[Category: Ngo, K]]
[[Category: Gloeckner, S]]
[[Category: Heine, A]]
[[Category: Klebe, G]]