6sfw - Revision history

OCA at 06:08, 11 April 2020

2020-04-11T06:08:06Z

←Older revision		Revision as of 06:08, 11 April 2020
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	<SX load='6sfw' size='340' side='right' viewer='molstar' caption='[[6sfw]], [[Resolution\|resolution]] 6.00Å' scene=''>		<SX load='6sfw' size='340' side='right' viewer='molstar' caption='[[6sfw]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sfw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_monocytogenes_hominis"_nyfeldt_1932 "bacterium monocytogenes hominis" nyfeldt 1932]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SFW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SFW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sfw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_monocytogenes_hominis"_nyfeldt_1932 "bacterium monocytogenes hominis" nyfeldt 1932]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SFW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SFW FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sfx\|6sfx]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sfx\|6sfx]]</td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpX, ARJ20_08095, B4Y57_02215, D3B94_07125, DWE46_10580, DWE48_07885, FA029_07915, FORC68_1290, LmNIHS28_00678 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1639 "Bacterium monocytogenes hominis" Nyfeldt 1932])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpX, ARJ20_08095, B4Y57_02215, D3B94_07125, DWE46_10580, DWE48_07885, FA029_07915, FORC68_1290, LmNIHS28_00678 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1639 "Bacterium monocytogenes hominis" Nyfeldt 1932])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sfw OCA], [http://pdbe.org/6sfw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sfw RCSB], [http://www.ebi.ac.uk/pdbsum/6sfw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sfw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sfw OCA], [http://pdbe.org/6sfw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sfw RCSB], [http://www.ebi.ac.uk/pdbsum/6sfw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sfw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 00:47, 7 March 2020

2020-03-07T00:47:02Z

←Older revision		Revision as of 00:47, 7 March 2020
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	==Cryo-EM Structure of the ClpX component of the ClpXP1/2 degradation machinery.==		==Cryo-EM Structure of the ClpX component of the ClpXP1/2 degradation machinery.==
-	<~~StructureSection~~ load='6sfw' size='340' side='right'caption='[[6sfw]], [[Resolution\|resolution]] 6.00Å' scene=''>	+	<SX load='6sfw' size='340' side='right' viewer='molstar' caption='[[6sfw]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6sfw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_monocytogenes_hominis"_nyfeldt_1932 "bacterium monocytogenes hominis" nyfeldt 1932]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SFW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SFW FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sfw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_monocytogenes_hominis"_nyfeldt_1932 "bacterium monocytogenes hominis" nyfeldt 1932]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SFW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SFW FirstGlance]. <br>
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	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Bacterium monocytogenes hominis nyfeldt 1932]]		[[Category: Bacterium monocytogenes hominis nyfeldt 1932]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 16:52, 22 January 2020

2020-01-22T16:52:58Z

←Older revision		Revision as of 16:52, 22 January 2020
Line 3:		Line 3:
	<StructureSection load='6sfw' size='340' side='right'caption='[[6sfw]], [[Resolution\|resolution]] 6.00Å' scene=''>		<StructureSection load='6sfw' size='340' side='right'caption='[[6sfw]], [[Resolution\|resolution]] 6.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sfw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SFW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SFW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sfw]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_monocytogenes_hominis"_nyfeldt_1932 "bacterium monocytogenes hominis" nyfeldt 1932]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SFW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SFW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sfw OCA], [http://pdbe.org/6sfw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sfw RCSB], [http://www.ebi.ac.uk/pdbsum/6sfw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sfw ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6sfx\|6sfx]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">clpX, ARJ20_08095, B4Y57_02215, D3B94_07125, DWE46_10580, DWE48_07885, FA029_07915, FORC68_1290, LmNIHS28_00678 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1639 "Bacterium monocytogenes hominis" Nyfeldt 1932])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sfw OCA], [http://pdbe.org/6sfw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sfw RCSB], [http://www.ebi.ac.uk/pdbsum/6sfw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sfw ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacterium monocytogenes hominis nyfeldt 1932]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gatsogiannis, C]]		[[Category: Gatsogiannis, C]]

OCA at 06:02, 16 October 2019

2019-10-16T06:02:17Z

←Older revision		Revision as of 06:02, 16 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6sfw is ~~ON HOLD~~	+	==Cryo-EM Structure of the ClpX component of the ClpXP1/2 degradation machinery.==
		+	<StructureSection load='6sfw' size='340' side='right'caption='[[6sfw]], [[Resolution\|resolution]] 6.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6sfw]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SFW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SFW FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sfw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sfw OCA], [http://pdbe.org/6sfw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sfw RCSB], [http://www.ebi.ac.uk/pdbsum/6sfw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sfw ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/L8DZH5_LISMN L8DZH5_LISMN]] ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.[HAMAP-Rule:MF_00175][SAAS:SAAS01076750]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The ClpXP machinery is a two-component protease complex that performs targeted protein degradation in bacteria and mitochondria. The complex consists of the AAA+ chaperone ClpX and the peptidase ClpP. The hexameric ClpX utilizes the energy of ATP binding and hydrolysis to engage, unfold and translocate substrates into the catalytic chamber of tetradecameric ClpP, where they are degraded. Formation of the complex involves a symmetry mismatch, because hexameric AAA+ rings bind axially to the opposing stacked heptameric rings of the tetradecameric ClpP. Here we present the cryo-EM structure of ClpXP from Listeria monocytogenes. We unravel the heptamer-hexamer binding interface and provide novel insight into the ClpX-ClpP cross-talk and activation mechanism. Comparison with available crystal structures of ClpP and ClpX in different states allows us to understand important aspects of the complex mode of action of ClpXP and provides a structural framework for future pharmacological applications.

-	~~Authors: Gatsogiannis~~, C., ~~Merino~~, F., ~~Raunser~~, S.	+	Cryo-EM structure of the ClpXP protein degradation machinery.,Gatsogiannis C, Balogh D, Merino F, Sieber SA, Raunser S Nat Struct Mol Biol. 2019 Oct;26(10):946-954. doi: 10.1038/s41594-019-0304-0., Epub 2019 Oct 3. PMID:31582852<ref>PMID:31582852</ref>

-	~~Description: Cryo-EM Structure~~ of the ~~ClpX component~~ of ~~the ClpXP1/2 degradation machinery~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Merino, F~~]]	+	<div class="pdbe-citations 6sfw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Gatsogiannis, C]]		[[Category: Gatsogiannis, C]]
		+	[[Category: Merino, F]]
	[[Category: Raunser, S]]		[[Category: Raunser, S]]
		+	[[Category: Aaa+]]
		+	[[Category: Atpase]]
		+	[[Category: Chaperone]]
		+	[[Category: Listeria]]
		+	[[Category: Motor protein]]
		+	[[Category: Protease]]
		+	[[Category: Transport protein]]

OCA: Protected "6sfw" [edit=sysop:move=sysop]

2019-08-14T15:10:18Z

Protected "6sfw" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:10, 14 August 2019

OCA: New page: '''Unreleased structure''' The entry 6sfw is ON HOLD Authors: Gatsogiannis, C., Merino, F., Raunser, S. Description: Cryo-EM Structure of the ClpX component of the ClpXP1/2 degradation...

2019-08-14T15:10:16Z

New page: '''Unreleased structure''' The entry 6sfw is ON HOLD Authors: Gatsogiannis, C., Merino, F., Raunser, S. Description: Cryo-EM Structure of the ClpX component of the ClpXP1/2 degradation...

New page

'''Unreleased structure'''

The entry 6sfw is ON HOLD

Authors: Gatsogiannis, C., Merino, F., Raunser, S.

Description: Cryo-EM Structure of the ClpX component of the ClpXP1/2 degradation machinery.
[[Category: Unreleased Structures]]
[[Category: Merino, F]]
[[Category: Gatsogiannis, C]]
[[Category: Raunser, S]]