6sg0 - Revision history

OCA at 12:41, 24 January 2024

2024-01-24T12:41:26Z

←Older revision		Revision as of 12:41, 24 January 2024
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	==Atomic resolution structure of Human Carbonic Anhydrase II in complex with furosemide==		==Atomic resolution structure of Human Carbonic Anhydrase II in complex with furosemide==
-	<StructureSection load='6sg0' size='340' side='right'caption='[[6sg0]]' scene=''>	+	<StructureSection load='6sg0' size='340' side='right'caption='[[6sg0]], [[Resolution\|resolution]] 1.13Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SG0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SG0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sg0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SG0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SG0 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6sg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sg0 OCA], [~~http~~://pdbe.org/6sg0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sg0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sg0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sg0 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.13Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BE7:(4-CARBOXYPHENYL)(CHLORO)MERCURY'>BE7</scene>, <scene name='pdbligand=FUN:5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC+ACID'>FUN</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sg0 OCA], [https://pdbe.org/6sg0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sg0 RCSB], [https://www.ebi.ac.uk/pdbsum/6sg0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sg0 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Defects in CA2 are the cause of osteopetrosis autosomal recessive type 3 (OPTB3) [MIM:[https://omim.org/entry/259730 259730]; also known as osteopetrosis with renal tubular acidosis, carbonic anhydrase II deficiency syndrome, Guibaud-Vainsel syndrome or marble brain disease. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts. OPTB3 is associated with renal tubular acidosis, cerebral calcification (marble brain disease) and in some cases with mental retardation.<ref>PMID:1928091</ref> <ref>PMID:1542674</ref> <ref>PMID:8834238</ref> <ref>PMID:9143915</ref> <ref>PMID:15300855</ref>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CAH2_HUMAN CAH2_HUMAN] Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.<ref>PMID:10550681</ref> <ref>PMID:11831900</ref>
		+
		+	==See Also==
		+	*[[Carbonic anhydrase 3D structures\|Carbonic anhydrase 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Gloeckner S]]		[[Category: Gloeckner S]]
	[[Category: Heine A]]		[[Category: Heine A]]
	[[Category: Klebe G]]		[[Category: Klebe G]]

OCA at 11:13, 26 August 2020

2020-08-26T11:13:58Z

←Older revision		Revision as of 11:13, 26 August 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6sg0 ~~is ON HOLD until Paper Publication~~	+	==Atomic resolution structure of Human Carbonic Anhydrase II in complex with furosemide==
-		+	<StructureSection load='6sg0' size='340' side='right'caption='[[6sg0]]' scene=''>
-	~~Authors~~: ~~Gloeckner~~, S., ~~Heine~~, A., ~~Klebe~~, G.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SG0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SG0 FirstGlance]. <br>
-	~~Description: Atomic resolution structure of Human Carbonic Anhydrase II in complex with furosemide~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sg0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sg0 OCA], [http://pdbe.org/6sg0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sg0 RCSB], [http://www.ebi.ac.uk/pdbsum/6sg0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sg0 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Gloeckner, S]]	+	__TOC__
-	[[Category: Heine, A]]	+	</StructureSection>
-	[[Category: Klebe, G]]	+	[[Category: Large Structures]]
		+	[[Category: Gloeckner S]]
		+	[[Category: Heine A]]
		+	[[Category: Klebe G]]

OCA: Protected "6sg0" [edit=sysop:move=sysop]

2019-08-14T15:10:33Z

Protected "6sg0" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:10, 14 August 2019

OCA: New page: '''Unreleased structure''' The entry 6sg0 is ON HOLD until Paper Publication Authors: Gloeckner, S., Heine, A., Klebe, G. Description: Atomic resolution structure of Human Carbonic Anh...

2019-08-14T15:10:32Z

New page: '''Unreleased structure''' The entry 6sg0 is ON HOLD until Paper Publication Authors: Gloeckner, S., Heine, A., Klebe, G. Description: Atomic resolution structure of Human Carbonic Anh...

New page

'''Unreleased structure'''

The entry 6sg0 is ON HOLD until Paper Publication

Authors: Gloeckner, S., Heine, A., Klebe, G.

Description: Atomic resolution structure of Human Carbonic Anhydrase II in complex with furosemide
[[Category: Unreleased Structures]]
[[Category: Gloeckner, S]]
[[Category: Heine, A]]
[[Category: Klebe, G]]