6sie - Revision history

OCA at 12:42, 24 January 2024

2024-01-24T12:42:18Z

←Older revision		Revision as of 12:42, 24 January 2024
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	<StructureSection load='6sie' size='340' side='right'caption='[[6sie]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6sie' size='340' side='right'caption='[[6sie]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sie]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sie]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SIE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Arc2, CG13941 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sie OCA], [https://pdbe.org/6sie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sie RCSB], [https://www.ebi.ac.uk/pdbsum/6sie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sie ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sie OCA], [https://pdbe.org/6sie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sie RCSB], [https://www.ebi.ac.uk/pdbsum/6sie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sie ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/ARC2_DROME ARC2_DROME]] Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer. Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells.[UniProtKB:Q7K1U0]	+	[https://www.uniprot.org/uniprot/ARC2_DROME ARC2_DROME] Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer. Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells.[UniProtKB:Q7K1U0]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Hallin~~, E I~~]]	+	[[Category: Hallin EI]]
-	[[Category: Kursula, P]]	+	[[Category: Kursula P]]
-	~~[[Category: Arc]]~~	+
-	~~[[Category: Atomic resolution]]~~	+
-	~~[[Category: Capsid assembly]]~~	+
-	~~[[Category: Gag homology]]~~	+
-	~~[[Category: Virus like particle~~]]	+

OCA at 15:31, 22 December 2021

2021-12-22T15:31:20Z

←Older revision		Revision as of 15:31, 22 December 2021
Line 3:		Line 3:
	<StructureSection load='6sie' size='340' side='right'caption='[[6sie]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6sie' size='340' side='right'caption='[[6sie]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sie]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SIE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sie]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SIE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arc2, CG13941 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arc2, CG13941 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sie OCA], [~~http~~://pdbe.org/6sie PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sie RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sie PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sie ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sie OCA], [https://pdbe.org/6sie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sie RCSB], [https://www.ebi.ac.uk/pdbsum/6sie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sie ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/ARC2_DROME ARC2_DROME]] Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer. Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells.[UniProtKB:Q7K1U0]	+	[[https://www.uniprot.org/uniprot/ARC2_DROME ARC2_DROME]] Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer. Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells.[UniProtKB:Q7K1U0]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the activity-regulated cytoskeleton-associated protein (Arc). Mammalian Arc forms virus-like capsid structures in a process requiring the N-terminal domain and contains two C-terminal lobes that are structural homologues to retroviral capsids. Drosophila has two isoforms of Arc, dArc1 and dArc2, with low sequence similarity to mammalian Arc, but lacking a large N-terminal domain. Both dArc isoforms are related to the Ty3/gypsy retrotransposon capsid, consisting of N- and C-terminal lobes. Structures of dArc1, as well as capsids formed by both dArc isoforms, have been recently determined. We carried out structural characterization of the four individual dArc lobe domains. As opposed to the corresponding mammalian Arc lobe domains, which are monomeric, the dArc lobes were all oligomeric in solution, indicating a strong propensity for homophilic interactions. A truncated N-lobe from dArc2 formed a domain-swapped dimer in the crystal structure, resulting in a novel dimer interaction that could be relevant for capsid assembly or other dArc functions. This domain-swapped structure resembles the dimeric protein C of flavivirus capsids, as well as the structure of histones dimers, domain-swapped transcription factors, and membrane-interacting BAK domains. The strong oligomerization properties of the isolated dArc lobe domains explain the ability of dArc to form capsids in the absence of any large N-terminal domain, in contrast to the mammalian protein.
		+
		+	Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc.,Hallin EI, Markusson S, Bottger L, Torda AE, Bramham CR, Kursula P PLoS One. 2021 May 14;16(5):e0251459. doi: 10.1371/journal.pone.0251459., eCollection 2021. PMID:33989344<ref>PMID:33989344</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6sie" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 08:15, 23 October 2019

2019-10-23T08:15:15Z

←Older revision		Revision as of 08:15, 23 October 2019
Line 3:		Line 3:
	<StructureSection load='6sie' size='340' side='right'caption='[[6sie]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='6sie' size='340' side='right'caption='[[6sie]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SIE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sie]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SIE FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Arc2, CG13941 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sie OCA], [http://pdbe.org/6sie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sie RCSB], [http://www.ebi.ac.uk/pdbsum/6sie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sie ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sie OCA], [http://pdbe.org/6sie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sie RCSB], [http://www.ebi.ac.uk/pdbsum/6sie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sie ProSAT]</span></td></tr>
	</table>		</table>
Line 11:		Line 12:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Hallin, E I]]		[[Category: Hallin, E I]]

OCA at 15:44, 28 August 2019

2019-08-28T15:44:01Z

←Older revision		Revision as of 15:44, 28 August 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6sie is ~~ON HOLD~~	+	==Crystal structure of the C-lobe of drosophila Arc 2==
-		+	<StructureSection load='6sie' size='340' side='right'caption='[[6sie]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Hallin~~, E.I., ~~Kursula~~, P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6sie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SIE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SIE FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the C~~-~~lobe~~ of ~~drosophila Arc 2~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sie OCA], [http://pdbe.org/6sie PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sie RCSB], [http://www.ebi.ac.uk/pdbsum/6sie PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sie ProSAT]</span></td></tr>
-	[[Category: Hallin, E.I]]	+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ARC2_DROME ARC2_DROME]] Self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer. Arc2 protein is released from cells in extracellular vesicles that mediate the transfer of mRNA into neighboring cells.[UniProtKB:Q7K1U0]
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Hallin, E I]]
	[[Category: Kursula, P]]		[[Category: Kursula, P]]
		+	[[Category: Arc]]
		+	[[Category: Atomic resolution]]
		+	[[Category: Capsid assembly]]
		+	[[Category: Gag homology]]
		+	[[Category: Virus like particle]]

OCA: Protected "6sie" [edit=sysop:move=sysop]

2019-08-21T04:16:54Z

Protected "6sie" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:16, 21 August 2019

OCA: New page: '''Unreleased structure''' The entry 6sie is ON HOLD Authors: Hallin, E.I., Kursula, P. Description: Crystal structure of the C-lobe of drosophila Arc 2 [[Category: Unreleased Structur...

2019-08-21T04:16:53Z

New page: '''Unreleased structure''' The entry 6sie is ON HOLD Authors: Hallin, E.I., Kursula, P. Description: Crystal structure of the C-lobe of drosophila Arc 2 [[Category: Unreleased Structur...

New page

'''Unreleased structure'''

The entry 6sie is ON HOLD

Authors: Hallin, E.I., Kursula, P.

Description: Crystal structure of the C-lobe of drosophila Arc 2
[[Category: Unreleased Structures]]
[[Category: Hallin, E.I]]
[[Category: Kursula, P]]