6sp2 - Revision history

OCA at 11:09, 30 March 2022

2022-03-30T11:09:08Z

←Older revision		Revision as of 11:09, 30 March 2022
Line 3:		Line 3:
	<SX load='6sp2' size='340' side='right' viewer='molstar' caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>		<SX load='6sp2' size='340' side='right' viewer='molstar' caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMS1, CG4672 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMS1, CG4672 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6sp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sp2 OCA], [~~http~~://pdbe.org/6sp2 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6sp2 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6sp2 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6sp2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sp2 OCA], [https://pdbe.org/6sp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sp2 RCSB], [https://www.ebi.ac.uk/pdbsum/6sp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sp2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 06:15, 11 April 2020

2020-04-11T06:15:19Z

←Older revision		Revision as of 06:15, 11 April 2020
Line 3:		Line 3:
	<SX load='6sp2' size='340' side='right' viewer='molstar' caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>		<SX load='6sp2' size='340' side='right' viewer='molstar' caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMS1, CG4672 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMS1, CG4672 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6sp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sp2 OCA], [http://pdbe.org/6sp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sp2 RCSB], [http://www.ebi.ac.uk/pdbsum/6sp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sp2 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6sp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sp2 OCA], [http://pdbe.org/6sp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sp2 RCSB], [http://www.ebi.ac.uk/pdbsum/6sp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sp2 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 00:54, 7 March 2020

2020-03-07T00:54:26Z

←Older revision		Revision as of 00:54, 7 March 2020
Line 1:		Line 1:

	==CryoEM structure of SERINC from Drosophila melanogaster==		==CryoEM structure of SERINC from Drosophila melanogaster==
-	<~~StructureSection~~ load='6sp2' size='340' side='right'caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>	+	<SX load='6sp2' size='340' side='right' viewer='molstar' caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>
Line 20:		Line 20:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Drome]]		[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 16:54, 22 January 2020

2020-01-22T16:54:03Z

←Older revision		Revision as of 16:54, 22 January 2020
Line 3:		Line 3:
	<StructureSection load='6sp2' size='340' side='right'caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>		<StructureSection load='6sp2' size='340' side='right'caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TMS1, CG4672 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sp2 OCA], [http://pdbe.org/6sp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sp2 RCSB], [http://www.ebi.ac.uk/pdbsum/6sp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sp2 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sp2 OCA], [http://pdbe.org/6sp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sp2 RCSB], [http://www.ebi.ac.uk/pdbsum/6sp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sp2 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The human integral membrane protein SERINC5 potently restricts HIV-1 infectivity and sensitizes the virus to antibody-mediated neutralization. Here, using cryo-EM, we determine the structures of human SERINC5 and its orthologue from Drosophila melanogaster at subnanometer and near-atomic resolution, respectively. The structures reveal a novel fold comprised of ten transmembrane helices organized into two subdomains and bisected by a long diagonal helix. A lipid binding groove and clusters of conserved residues highlight potential functional sites. A structure-based mutagenesis scan identified surface-exposed regions and the interface between the subdomains of SERINC5 as critical for HIV-1-restriction activity. The same regions are also important for viral sensitization to neutralizing antibodies, directly linking the antiviral activity of SERINC5 with remodeling of the HIV-1 envelope glycoprotein.
		+
		+	A bipartite structural organization defines the SERINC family of HIV-1 restriction factors.,Pye VE, Rosa A, Bertelli C, Struwe WB, Maslen SL, Corey R, Liko I, Hassall M, Mattiuzzo G, Ballandras-Colas A, Nans A, Takeuchi Y, Stansfeld PJ, Skehel JM, Robinson CV, Pizzato M, Cherepanov P Nat Struct Mol Biol. 2020 Jan;27(1):78-83. doi: 10.1038/s41594-019-0357-0. Epub, 2020 Jan 6. PMID:31907454<ref>PMID:31907454</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6sp2" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Cherepanov, P]]		[[Category: Cherepanov, P]]

OCA at 08:22, 1 January 2020

2020-01-01T08:22:45Z

←Older revision		Revision as of 08:22, 1 January 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6sp2 ~~is ON HOLD until Paper Publication~~	+	==CryoEM structure of SERINC from Drosophila melanogaster==
-		+	<StructureSection load='6sp2' size='340' side='right'caption='[[6sp2]], [[Resolution\|resolution]] 3.33Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6sp2]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SP2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SP2 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=LMN:LAURYL+MALTOSE+NEOPENTYL+GLYCOL'>LMN</scene>, <scene name='pdbligand=P5S:O-[(R)-{[(2R)-2,3-BIS(OCTADECANOYLOXY)PROPYL]OXY}(HYDROXY)PHOSPHORYL]-L-SERINE'>P5S</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sp2 OCA], [http://pdbe.org/6sp2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sp2 RCSB], [http://www.ebi.ac.uk/pdbsum/6sp2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sp2 ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Cherepanov, P]]
		+	[[Category: Nans, A]]
		+	[[Category: Pye, V E]]
		+	[[Category: Anti-retroviral]]
		+	[[Category: Membrane protein]]
		+	[[Category: Novel fold]]
		+	[[Category: Serinc fold]]
		+	[[Category: Tm10]]

OCA at 13:32, 11 December 2019

2019-12-11T13:32:05Z

←Older revision		Revision as of 13:32, 11 December 2019
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6sp2 is ON HOLD	+	The entry 6sp2 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6sp2" [edit=sysop:move=sysop]

2019-10-02T07:30:51Z

Protected "6sp2" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:30, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6sp2 is ON HOLD Authors: Description: Category: Unreleased Structures

2019-10-02T07:30:49Z

New page: '''Unreleased structure''' The entry 6sp2 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6sp2 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]