6taz - Revision history

OCA at 11:03, 14 June 2023

2023-06-14T11:03:09Z

←Older revision		Revision as of 11:03, 14 June 2023
Line 1:		Line 1:

	==Timeless couples G quadruplex detection with processing by DDX11 during DNA replication==		==Timeless couples G quadruplex detection with processing by DDX11 during DNA replication==
-	<StructureSection load='6taz' size='340' side='right'caption='[[6taz~~]], [[NMR_Ensembles_of_Models \| 20 NMR models~~]]' scene=''>	+	<StructureSection load='6taz' size='340' side='right'caption='[[6taz]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6taz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Human Human~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6taz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TAZ FirstGlance]. <br>
-	</td></tr>~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6t9q\|6t9q]]</div></td></tr>~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6taz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6taz OCA], [https://pdbe.org/6taz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6taz RCSB], [https://www.ebi.ac.uk/pdbsum/6taz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6taz ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIMELESS, TIM, TIM1, TIMELESS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6taz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6taz OCA], [https://pdbe.org/6taz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6taz RCSB], [https://www.ebi.ac.uk/pdbsum/6taz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6taz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/TIM_HUMAN TIM_HUMAN]] Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK\|NPAS2-ARTNL/BMAL1\|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.<ref>PMID:17141802</ref> <ref>PMID:17296725</ref> <ref>PMID:23418588</ref> <ref>PMID:9856465</ref>	+	[https://www.uniprot.org/uniprot/TIM_HUMAN TIM_HUMAN] Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK\|NPAS2-ARTNL/BMAL1\|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.<ref>PMID:17141802</ref> <ref>PMID:17296725</ref> <ref>PMID:23418588</ref> <ref>PMID:9856465</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bittleston, A]]	+	[[Category: Bittleston A]]
-	[[Category: Branzei, D]]	+	[[Category: Branzei D]]
-	[[Category: Holzer, S]]	+	[[Category: Holzer S]]
-	[[Category: Kilkenny~~, M L~~]]	+	[[Category: Kilkenny ML]]
-	[[Category: Koch, L ~~Lerner~~]]	+	[[Category: Lerner Koch L]]
-	[[Category: Maman~~, J D~~]]	+	[[Category: Maman JD]]
-	[[Category: Murat, P]]	+	[[Category: Murat P]]
-	[[Category: Pellegrini, L]]	+	[[Category: Pellegrini L]]
-	[[Category: Sale~~, E J~~]]	+	[[Category: Sale EJ]]
-	[[Category: Schiavone, D]]	+	[[Category: Schiavone D]]
-	[[Category: Stott, K]]	+	[[Category: Stott K]]
-	[[Category: Svikovic, S]]	+	[[Category: Svikovic S]]
-	~~[[Category: 3-helix bundle]]~~	+
-	~~[[Category: Dna binding protein]]~~	+
-	~~[[Category: Dna-binding protein]]~~	+
-	~~[[Category: Tandem repeat~~]]	+

OCA at 08:55, 18 February 2021

2021-02-18T08:55:58Z

←Older revision		Revision as of 08:55, 18 February 2021
Line 3:		Line 3:
	<StructureSection load='6taz' size='340' side='right'caption='[[6taz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>		<StructureSection load='6taz' size='340' side='right'caption='[[6taz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6taz]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6taz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TAZ FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6t9q\|6t9q]]</div></td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6t9q\|6t9q]]</div></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIMELESS, TIM, TIM1, TIMELESS1 ([~~http~~://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIMELESS, TIM, TIM1, TIMELESS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6taz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6taz OCA], [~~http~~://pdbe.org/6taz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6taz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6taz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6taz ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6taz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6taz OCA], [https://pdbe.org/6taz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6taz RCSB], [https://www.ebi.ac.uk/pdbsum/6taz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6taz ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/TIM_HUMAN TIM_HUMAN]] Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK\|NPAS2-ARTNL/BMAL1\|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.<ref>PMID:17141802</ref> <ref>PMID:17296725</ref> <ref>PMID:23418588</ref> <ref>PMID:9856465</ref>	+	[[https://www.uniprot.org/uniprot/TIM_HUMAN TIM_HUMAN]] Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK\|NPAS2-ARTNL/BMAL1\|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.<ref>PMID:17141802</ref> <ref>PMID:17296725</ref> <ref>PMID:23418588</ref> <ref>PMID:9856465</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 12:46, 16 December 2020

2020-12-16T12:46:38Z

←Older revision		Revision as of 12:46, 16 December 2020
Line 1:		Line 1:

	==Timeless couples G quadruplex detection with processing by DDX11 during DNA replication==		==Timeless couples G quadruplex detection with processing by DDX11 during DNA replication==
-	<StructureSection load='6taz' size='340' side='right'caption='[[6taz]]' scene=''>	+	<StructureSection load='6taz' size='340' side='right'caption='[[6taz]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TAZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6taz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TAZ FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6taz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6taz OCA], [http://pdbe.org/6taz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6taz RCSB], [http://www.ebi.ac.uk/pdbsum/6taz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6taz ProSAT]</span></td></tr>	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6t9q\|6t9q]]</div></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TIMELESS, TIM, TIM1, TIMELESS1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6taz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6taz OCA], [http://pdbe.org/6taz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6taz RCSB], [http://www.ebi.ac.uk/pdbsum/6taz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6taz ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TIM_HUMAN TIM_HUMAN]] Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK\|NPAS2-ARTNL/BMAL1\|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.<ref>PMID:17141802</ref> <ref>PMID:17296725</ref> <ref>PMID:23418588</ref> <ref>PMID:9856465</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Regions of the genome with the potential to form secondary DNA structures pose a frequent and significant impediment to DNA replication and must be actively managed in order to preserve genetic and epigenetic integrity. How the replisome detects and responds to secondary structures is poorly understood. Here, we show that a core component of the fork protection complex in the eukaryotic replisome, Timeless, harbours in its C-terminal region a previously unappreciated DNA-binding domain that exhibits specific binding to G-quadruplex (G4) DNA structures. We show that this domain contributes to maintaining processive replication through G4-forming sequences, and exhibits partial redundancy with an adjacent PARP-binding domain. Further, this function of Timeless requires interaction with and activity of the helicase DDX11. Loss of both Timeless and DDX11 causes epigenetic instability at G4-forming sequences and DNA damage. Our findings indicate that Timeless contributes to the ability of the replisome to sense replication-hindering G4 formation and ensures the prompt resolution of these structures by DDX11 to maintain processive DNA synthesis.
		+
		+	Timeless couples G-quadruplex detection with processing by DDX11 helicase during DNA replication.,Lerner LK, Holzer S, Kilkenny ML, Svikovic S, Murat P, Schiavone D, Eldridge CB, Bittleston A, Maman JD, Branzei D, Stott K, Pellegrini L, Sale JE EMBO J. 2020 Jul 23:e104185. doi: 10.15252/embj.2019104185. PMID:32705708<ref>PMID:32705708</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6taz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bittleston A]]	+	[[Category: Bittleston, A]]
-	[[Category: Branzei D]]	+	[[Category: Branzei, D]]
-	[[Category: Holzer S]]	+	[[Category: Holzer, S]]
-	[[Category: Kilkenny ML]]	+	[[Category: Kilkenny, M L]]
-	[[Category: ~~Lerner~~ Koch L]]	+	[[Category: Koch, L Lerner]]
-	[[Category: Maman JD]]	+	[[Category: Maman, J D]]
-	[[Category: Murat P]]	+	[[Category: Murat, P]]
-	[[Category: Pellegrini L]]	+	[[Category: Pellegrini, L]]
-	[[Category: Sale EJ]]	+	[[Category: Sale, E J]]
-	[[Category: Schiavone D]]	+	[[Category: Schiavone, D]]
-	[[Category: Stott K]]	+	[[Category: Stott, K]]
-	[[Category: Svikovic S]]	+	[[Category: Svikovic, S]]
		+	[[Category: 3-helix bundle]]
		+	[[Category: Dna binding protein]]
		+	[[Category: Dna-binding protein]]
		+	[[Category: Tandem repeat]]

OCA at 10:00, 12 August 2020

2020-08-12T10:00:46Z

←Older revision		Revision as of 10:00, 12 August 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6taz is ~~ON HOLD~~	+	==Timeless couples G quadruplex detection with processing by DDX11 during DNA replication==
-		+	<StructureSection load='6taz' size='340' side='right'caption='[[6taz]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TAZ FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6taz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6taz OCA], [http://pdbe.org/6taz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6taz RCSB], [http://www.ebi.ac.uk/pdbsum/6taz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6taz ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Bittleston A]]
		+	[[Category: Branzei D]]
		+	[[Category: Holzer S]]
		+	[[Category: Kilkenny ML]]
		+	[[Category: Lerner Koch L]]
		+	[[Category: Maman JD]]
		+	[[Category: Murat P]]
		+	[[Category: Pellegrini L]]
		+	[[Category: Sale EJ]]
		+	[[Category: Schiavone D]]
		+	[[Category: Stott K]]
		+	[[Category: Svikovic S]]

OCA at 13:51, 22 January 2020

2020-01-22T13:51:35Z

←Older revision		Revision as of 13:51, 22 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6taz is ON HOLD ~~until sometime in the future~~	+	The entry 6taz is ON HOLD

	Authors:		Authors:

OCA: Protected "6taz" [edit=sysop:move=sysop]

2019-11-06T05:16:00Z

Protected "6taz" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:16, 6 November 2019

OCA: New page: '''Unreleased structure''' The entry 6taz is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

2019-11-06T05:15:58Z

New page: '''Unreleased structure''' The entry 6taz is ON HOLD until sometime in the future Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6taz is ON HOLD until sometime in the future

Authors:

Description:
[[Category: Unreleased Structures]]