http://52.214.119.220/wiki/index.php?action=history&feed=atom&title=6tjt
6tjt - Revision history
2026-04-04T03:36:03Z
Revision history for this page on the wiki
MediaWiki 1.11.2
http://52.214.119.220/wiki/index.php?title=6tjt&diff=4027079&oldid=prev
OCA at 13:03, 24 January 2024
2024-01-24T13:03:29Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 13:03, 24 January 2024</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>====</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>==<ins style="color: red; font-weight: bold; text-decoration: none;">Neuropilin2-b1 domain in a complex with the C-terminal VEGFC peptide</ins>==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><StructureSection load='6tjt' size='340' side='right'caption='[[6tjt]]' scene=''></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><StructureSection load='6tjt' size='340' side='right'caption='[[6tjt]]<ins style="color: red; font-weight: bold; text-decoration: none;">, [[Resolution|resolution]] 1.31&Aring;</ins>' scene=''></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Structural highlights ==</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><table><tr><td colspan='2'><ins style="color: red; font-weight: bold; text-decoration: none;">[[6tjt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. </ins>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=<ins style="color: red; font-weight: bold; text-decoration: none;">6TJT </ins>OCA]. For a <b>guided tour on the structure components</b> use [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://proteopedia.org/fgij/fg.htm?mol=<ins style="color: red; font-weight: bold; text-decoration: none;">6TJT </ins>FirstGlance]. <br></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div></td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://proteopedia.org/fgij/fg.htm?mol=6tjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tjt OCA], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://pdbe.org/6tjt PDBe], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://www.rcsb.org/pdb/explore.do?structureId=6tjt RCSB], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://www.ebi.ac.uk/pdbsum/6tjt PDBsum], [<del style="color: red; font-weight: bold; text-decoration: none;">http</del>://prosat.h-its.org/prosat/prosatexe?pdbcode=6tjt ProSAT]</span></td></tr></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></td></tr><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.31&#8491;</td></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://proteopedia.org/fgij/fg.htm?mol=6tjt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tjt OCA], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://pdbe.org/6tjt PDBe], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://www.rcsb.org/pdb/explore.do?structureId=6tjt RCSB], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://www.ebi.ac.uk/pdbsum/6tjt PDBsum], [<ins style="color: red; font-weight: bold; text-decoration: none;">https</ins>://prosat.h-its.org/prosat/prosatexe?pdbcode=6tjt ProSAT]</span></td></tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></table></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>== Function ==</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[https://www.uniprot.org/uniprot/NRP2_HUMAN NRP2_HUMAN] High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>==See Also==</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>*[[Neuropilin|Neuropilin]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>__TOC__</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div></StructureSection></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Homo sapiens]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Large Structures]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Large Structures]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Z-disk</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Djordjevic S]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Eldrid C]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Fotinou C]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Yelland T]]</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">[[Category: Yu L</ins>]]</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=6tjt&diff=3330505&oldid=prev
OCA at 12:30, 16 December 2020
2020-12-16T12:30:15Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 12:30, 16 December 2020</td>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">The entry </del>6tjt <del style="color: red; font-weight: bold; text-decoration: none;">is ON HOLD until Paper Publication</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">====</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><StructureSection load='</ins>6tjt<ins style="color: red; font-weight: bold; text-decoration: none;">' size='340' side='right'caption='[[6tjt]]' scene=''></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Authors</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Eldrid, C</del>.<del style="color: red; font-weight: bold; text-decoration: none;">, Yu, L</del>.<del style="color: red; font-weight: bold; text-decoration: none;">, Yelland, T</del>.<del style="color: red; font-weight: bold; text-decoration: none;">, Fotinou, C., Djordjevic, S</del>.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">== Structural highlights ==</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"><table><tr><td colspan='2'>Full crystallographic information is available from [http</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//oca</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">weizmann</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">ac</ins>.<ins style="color: red; font-weight: bold; text-decoration: none;">il/oca-bin/ocashort?id= OCA]</ins>. <ins style="color: red; font-weight: bold; text-decoration: none;">For </ins>a <ins style="color: red; font-weight: bold; text-decoration: none;"><b>guided tour on </ins>the <ins style="color: red; font-weight: bold; text-decoration: none;">structure components</b> use </ins>[<ins style="color: red; font-weight: bold; text-decoration: none;">http</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//proteopedia.org/fgij/fg.htm?mol= FirstGlance</ins>]<ins style="color: red; font-weight: bold; text-decoration: none;">. <br></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">Description: Neuropilin2-b1 domain in </del>a <del style="color: red; font-weight: bold; text-decoration: none;">complex with </del>the <del style="color: red; font-weight: bold; text-decoration: none;">C-terminal VEGFC peptide</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'></ins>[<ins style="color: red; font-weight: bold; text-decoration: none;">http</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//proteopedia.org/fgij/fg.htm?mol=6tjt FirstGlance</ins>]<ins style="color: red; font-weight: bold; text-decoration: none;">, </ins>[<ins style="color: red; font-weight: bold; text-decoration: none;">http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tjt OCA], </ins>[<ins style="color: red; font-weight: bold; text-decoration: none;">http</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//pdbe.org/6tjt PDBe]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://www.rcsb.org/pdb/explore.do?structureId=6tjt RCSB</ins>]<ins style="color: red; font-weight: bold; text-decoration: none;">, </ins>[<ins style="color: red; font-weight: bold; text-decoration: none;">http</ins>:<ins style="color: red; font-weight: bold; text-decoration: none;">//www.ebi.ac.uk/pdbsum/6tjt PDBsum]</ins>, <ins style="color: red; font-weight: bold; text-decoration: none;">[http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tjt ProSAT</ins>]<ins style="color: red; font-weight: bold; text-decoration: none;"></span></td></tr></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[<del style="color: red; font-weight: bold; text-decoration: none;">[Category</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Unreleased Structures]</del>]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></table></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[<del style="color: red; font-weight: bold; text-decoration: none;">[Category</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Fotinou, C</del>]<del style="color: red; font-weight: bold; text-decoration: none;">]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">__TOC__</ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[<del style="color: red; font-weight: bold; text-decoration: none;">Category</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Djordjevic</del>, <del style="color: red; font-weight: bold; text-decoration: none;">S</del>]<del style="color: red; font-weight: bold; text-decoration: none;">]</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></StructureSection></ins></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[<del style="color: red; font-weight: bold; text-decoration: none;">[Category</del>: <del style="color: red; font-weight: bold; text-decoration: none;">Yelland</del>, <del style="color: red; font-weight: bold; text-decoration: none;">T]</del>]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Large Structures</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Yu, L</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: <ins style="color: red; font-weight: bold; text-decoration: none;">Z-disk</ins>]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: <del style="color: red; font-weight: bold; text-decoration: none;">Eldrid, C</del>]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=6tjt&diff=3265531&oldid=prev
OCA at 06:16, 22 July 2020
2020-07-22T06:16:52Z
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<td colspan='2' style="background-color: white; color:black;">Revision as of 06:16, 22 July 2020</td>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Unreleased structure'''</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>The entry 6tjt is ON HOLD </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>The entry 6tjt is ON HOLD <ins style="color: red; font-weight: bold; text-decoration: none;"> until Paper Publication</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S.</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Description: Neuropilin2-b1 domain in a complex with the C-terminal VEGFC peptide</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Description: Neuropilin2-b1 domain in a complex with the C-terminal VEGFC peptide</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Unreleased Structures]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Unreleased Structures]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Yu, L]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Fotinou, C]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Fotinou, C]]</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[Category: Eldrid, C]]</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Djordjevic, S]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Djordjevic, S]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Yelland, T]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[Category: Yelland, T]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Yu, L]]</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[Category: Eldrid, C]]</div></td></tr>
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OCA
http://52.214.119.220/wiki/index.php?title=6tjt&diff=3119183&oldid=prev
OCA: Protected "6tjt" [edit=sysop:move=sysop]
2019-12-04T06:28:02Z
<p>Protected "<a href="/wiki/index.php/6tjt" title="6tjt">6tjt</a>" [edit=sysop:move=sysop]</p>
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<td colspan='2' style="background-color: white; color:black;">Revision as of 06:28, 4 December 2019</td>
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OCA
http://52.214.119.220/wiki/index.php?title=6tjt&diff=3119182&oldid=prev
OCA: New page: '''Unreleased structure''' The entry 6tjt is ON HOLD Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S. Description: Neuropilin2-b1 domain in a complex with the C-te...
2019-12-04T06:28:00Z
<p>New page: '''Unreleased structure''' The entry 6tjt is ON HOLD Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S. Description: Neuropilin2-b1 domain in a complex with the C-te...</p>
<p><b>New page</b></p><div>'''Unreleased structure'''<br />
<br />
The entry 6tjt is ON HOLD <br />
<br />
Authors: Eldrid, C., Yu, L., Yelland, T., Fotinou, C., Djordjevic, S.<br />
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Description: Neuropilin2-b1 domain in a complex with the C-terminal VEGFC peptide<br />
[[Category: Unreleased Structures]]<br />
[[Category: Yu, L]]<br />
[[Category: Fotinou, C]]<br />
[[Category: Eldrid, C]]<br />
[[Category: Djordjevic, S]]<br />
[[Category: Yelland, T]]</div>
OCA