6tqe - Revision history

OCA at 10:18, 22 May 2024

2024-05-22T10:18:51Z

←Older revision		Revision as of 10:18, 22 May 2024
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	<StructureSection load='6tqe' size='340' side='right'caption='[[6tqe]], [[Resolution\|resolution]] 4.30Å' scene=''>		<StructureSection load='6tqe' size='340' side='right'caption='[[6tqe]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tqe]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus~~ tuberculosis~~" (zopf 1883) klein 1884~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6TQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tqe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TQE FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>~~, ~~<scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 4.3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">yddA, yddA_3, DSI35_15825, ERS007665_02362, ERS007670_02474, ERS023446_03427, ERS027651_03600, ERS027652_02163, ERS027654_01933, ERS027656_03005, ERS027659_02286, ERS027661_01835, ERS027666_01377, ERS124361_03074, EZX46_07135, FDK60_09470, SAMEA2682835_03741, SAMEA2682864_01404, SAMEA2683035_00870 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=~~Info&srchmode~~=5~~&id~~=~~1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6tqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tqe OCA], [~~http~~://pdbe.org/6tqe PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tqe RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tqe PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tqe ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tqe OCA], [https://pdbe.org/6tqe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tqe RCSB], [https://www.ebi.ac.uk/pdbsum/6tqe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tqe ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BACA_MYCTU BACA_MYCTU] Multi-solute ABC transporter that mediates uptake of unrelated hydrophilic compounds (PubMed:32296172). Can transport vitamin B12 and related corrinoids, and antimicrobial peptides such as bleomycin (PubMed:18996991, PubMed:32296172, PubMed:23407640). Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation (PubMed:32296172). Contributes to maintenance of chronic infections (PubMed:18996991).<ref>PMID:18996991</ref> <ref>PMID:23407640</ref> <ref>PMID:32296172</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gati, C]]	+	[[Category: Mycobacterium tuberculosis]]
-	[[Category: Guskov, A]]	+	[[Category: Gati C]]
-	[[Category: Rempel, S]]	+	[[Category: Guskov A]]
-	[[Category: Slotboom~~, D J]]~~	+	[[Category: Rempel S]]
-	~~[[Category: Abc transporter]]~~	+	[[Category: Slotboom DJ]]
-	~~[[Category: Cobalamin]]~~	+
-	~~[[Category: Exporter fold]]~~	+
-	~~[[Category: Import]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Tuberculosis]]~~	+
-	~~[[Category: Vitamin b12~~]]	+

OCA at 07:10, 29 April 2020

2020-04-29T07:10:41Z

←Older revision		Revision as of 07:10, 29 April 2020
Line 3:		Line 3:
	<StructureSection load='6tqe' size='340' side='right'caption='[[6tqe]], [[Resolution\|resolution]] 4.30Å' scene=''>		<StructureSection load='6tqe' size='340' side='right'caption='[[6tqe]], [[Resolution\|resolution]] 4.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tqe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6TQE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tqe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6TQE FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6tqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tqe OCA], [http://pdbe.org/6tqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tqe RCSB], [http://www.ebi.ac.uk/pdbsum/6tqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tqe ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">yddA, yddA_3, DSI35_15825, ERS007665_02362, ERS007670_02474, ERS023446_03427, ERS027651_03600, ERS027652_02163, ERS027654_01933, ERS027656_03005, ERS027659_02286, ERS027661_01835, ERS027666_01377, ERS124361_03074, EZX46_07135, FDK60_09470, SAMEA2682835_03741, SAMEA2682864_01404, SAMEA2683035_00870 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6tqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tqe OCA], [http://pdbe.org/6tqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tqe RCSB], [http://www.ebi.ac.uk/pdbsum/6tqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tqe ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis(2). Mtb does not encode any characterized cobalamin transporter(4-6); however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold(1). Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 A(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).
		+
		+	A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.,Rempel S, Gati C, Nijland M, Thangaratnarajah C, Karyolaimos A, de Gier JW, Guskov A, Slotboom DJ Nature. 2020 Apr;580(7803):409-412. doi: 10.1038/s41586-020-2072-8. Epub 2020 Mar, 25. PMID:32296172<ref>PMID:32296172</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tqe" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 09:21, 1 April 2020

2020-04-01T09:21:43Z

←Older revision		Revision as of 09:21, 1 April 2020
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-	'''Unreleased structure'''

-	The ~~entry~~ 6tqe ~~is ON HOLD until Paper Publication~~	+	==The structure of ABC transporter Rv1819c without addition of substrate==
-		+	<StructureSection load='6tqe' size='340' side='right'caption='[[6tqe]], [[Resolution\|resolution]] 4.30Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6tqe]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TQE FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tqe OCA], [http://pdbe.org/6tqe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tqe RCSB], [http://www.ebi.ac.uk/pdbsum/6tqe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tqe ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Gati, C]]
		+	[[Category: Guskov, A]]
		+	[[Category: Rempel, S]]
		+	[[Category: Slotboom, D J]]
		+	[[Category: Abc transporter]]
		+	[[Category: Cobalamin]]
		+	[[Category: Exporter fold]]
		+	[[Category: Import]]
		+	[[Category: Transport protein]]
		+	[[Category: Tuberculosis]]
		+	[[Category: Vitamin b12]]

OCA at 13:17, 29 January 2020

2020-01-29T13:17:07Z

←Older revision		Revision as of 13:17, 29 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tqe is ON HOLD	+	The entry 6tqe is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6tqe" [edit=sysop:move=sysop]

2019-12-25T07:22:10Z

Protected "6tqe" [edit=sysop:move=sysop]

←Older revision

Revision as of 07:22, 25 December 2019

OCA: New page: '''Unreleased structure''' The entry 6tqe is ON HOLD Authors: Description: Category: Unreleased Structures

2019-12-25T07:22:08Z

New page: '''Unreleased structure''' The entry 6tqe is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tqe is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]