6tvw - Revision history

OCA at 10:42, 15 November 2023

2023-11-15T10:42:39Z

←Older revision		Revision as of 10:42, 15 November 2023
Line 1:		Line 1:

-	====	+	==Structure of native gp41 derived peptide fusion inhibitor==
-	<StructureSection load='6tvw' size='340' side='right'caption='[[6tvw]]' scene=''>	+	<StructureSection load='6tvw' size='340' side='right'caption='[[6tvw]], [[Resolution\|resolution]] 1.45Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tvw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TVW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TVW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tvw OCA], [https://pdbe.org/6tvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tvw RCSB], [https://www.ebi.ac.uk/pdbsum/6tvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tvw ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.45Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O0B:(2~{S},3~{S})-2-azanyl-5,5,5-tris(fluoranyl)-3-methyl-pentanal'>O0B</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tvw OCA], [https://pdbe.org/6tvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tvw RCSB], [https://www.ebi.ac.uk/pdbsum/6tvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tvw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q5VGF0_9HIV1 Q5VGF0_9HIV1]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	With the emergence of novel viruses, the development of new antivirals is more urgent than ever. A key step in human immunodeficiency virus type 1 (HIV-1) infection is six-helix bundle formation within the envelope protein subunit gp41. Selective disruption of bundle formation by peptides has been shown to be effective; however, these drugs, exemplified by T20, are prone to rapid clearance from the patient. The incorporation of non-natural amino acids is known to improve these pharmacokinetic properties. Here, we evaluate a peptide inhibitor in which a critical Ile residue is replaced by fluorinated analogues. We characterized the influence of the fluorinated analogues on the biophysical properties of the peptide. Furthermore, we show that the fluorinated peptides can block HIV-1 infection of target cells at nanomolar levels. These findings demonstrate that fluorinated amino acids are appropriate tools for the development of novel peptide therapeutics.
		+
		+	Systematic Evaluation of Fluorination as Modification for Peptide-Based Fusion Inhibitors against HIV-1 Infection.,Huhmann S, Nyakatura EK, Rohrhofer A, Moschner J, Schmidt B, Eichler J, Roth C, Koksch B Chembiochem. 2021 Dec 10;22(24):3443-3451. doi: 10.1002/cbic.202100417. Epub 2021 , Oct 22. PMID:34605595<ref>PMID:34605595</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6tvw" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human immunodeficiency virus 1]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Eichler J]]
		+	[[Category: Huhmann S]]
		+	[[Category: Koksch B]]
		+	[[Category: Moschner J]]
		+	[[Category: Nyakatura EK]]
		+	[[Category: Rohrhofer A]]
		+	[[Category: Roth C]]
		+	[[Category: Schmidt B]]

OCA at 07:53, 27 January 2021

2021-01-27T07:53:34Z

←Older revision		Revision as of 07:53, 27 January 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tvw ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6tvw' size='340' side='right'caption='[[6tvw]]' scene=''>
-	~~Authors~~: ~~Huhmann, S~~.~~, Nyakatura, E~~.K.~~, Rohrhofer, A~~.~~, Schmidt, B~~.~~, Eichler, J~~.~~, Moschner, J., Roth, C., Koksch, B~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~Structure of native gp41 derived peptide fusion inhibitor~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tvw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tvw OCA], [https://pdbe.org/6tvw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tvw RCSB], [https://www.ebi.ac.uk/pdbsum/6tvw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tvw ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures~~]]	+	</table>
-	[~~[Category~~: ~~Koksch~~, ~~B]]~~	+	__TOC__
-	[~~[Category~~: ~~Schmidt, B~~]]	+	</StructureSection>
-	[~~[Category~~: ~~Moschner~~, ~~J]]~~	+	[[Category: Large Structures]]
-	[~~[Category~~: ~~Huhmann, S~~]]	+	[[Category: Z-disk]]
-	~~[[Category: Rohrhofer~~, ~~A]]~~	+
-	[~~[Category~~: ~~Eichler, J]~~]	+
-	[[Category: ~~Roth, C~~]]	+
-	[[Category: ~~Nyakatura, E.K~~]]	+

OCA at 13:18, 29 January 2020

2020-01-29T13:18:19Z

←Older revision		Revision as of 13:18, 29 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6tvw is ON HOLD	+	The entry 6tvw is ON HOLD until Paper Publication

	Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C., Koksch, B.		Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C., Koksch, B.
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	[[Category: Koksch, B]]		[[Category: Koksch, B]]
	[[Category: Schmidt, B]]		[[Category: Schmidt, B]]
		+	[[Category: Moschner, J]]
	[[Category: Huhmann, S]]		[[Category: Huhmann, S]]
	[[Category: Rohrhofer, A]]		[[Category: Rohrhofer, A]]
-	[[Category: Roth, C]]
-	[[Category: Moschner, J]]
	[[Category: Eichler, J]]		[[Category: Eichler, J]]
		+	[[Category: Roth, C]]
	[[Category: Nyakatura, E.K]]		[[Category: Nyakatura, E.K]]

OCA: Protected "6tvw" [edit=sysop:move=sysop]

2020-01-22T14:00:06Z

Protected "6tvw" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:00, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6tvw is ON HOLD Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C., Koksch, B. Description: Str...

2020-01-22T14:00:02Z

New page: '''Unreleased structure''' The entry 6tvw is ON HOLD Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C., Koksch, B. Description: Str...

New page

'''Unreleased structure'''

The entry 6tvw is ON HOLD

Authors: Huhmann, S., Nyakatura, E.K., Rohrhofer, A., Schmidt, B., Eichler, J., Moschner, J., Roth, C., Koksch, B.

Description: Structure of native gp41 derived peptide fusion inhibitor
[[Category: Unreleased Structures]]
[[Category: Koksch, B]]
[[Category: Schmidt, B]]
[[Category: Huhmann, S]]
[[Category: Rohrhofer, A]]
[[Category: Roth, C]]
[[Category: Moschner, J]]
[[Category: Eichler, J]]
[[Category: Nyakatura, E.K]]