6txk - Revision history

OCA at 13:11, 24 January 2024

2024-01-24T13:11:45Z

←Older revision		Revision as of 13:11, 24 January 2024
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	<StructureSection load='6txk' size='340' side='right'caption='[[6txk]], [[Resolution\|resolution]] 2.36Å' scene=''>		<StructureSection load='6txk' size='340' side='right'caption='[[6txk]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6txk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Thema Thema~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6txk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXK FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.359Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TM_1128 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Bacterial_non-heme_ferritin Bacterial non-heme ferritin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.2 1.16.3.2] </span></td></tr>	+
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txk OCA], [https://pdbe.org/6txk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txk RCSB], [https://www.ebi.ac.uk/pdbsum/6txk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txk ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txk OCA], [https://pdbe.org/6txk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txk RCSB], [https://www.ebi.ac.uk/pdbsum/6txk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txk ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/Q9X0L2_THEMA Q9X0L2_THEMA]] Iron storage protein (By similarity).[RuleBase:RU361145]	+	[https://www.uniprot.org/uniprot/Q9X0L2_THEMA Q9X0L2_THEMA] Iron storage protein (By similarity).[RuleBase:RU361145]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 6txk" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6txk" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacterial non-heme ferritin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Thema~~]]	+	[[Category: Thermotoga maritima MSB8]]
-	[[Category: Chakraborti, S]]	+	[[Category: Chakraborti S]]
-	[[Category: Grudnik, P]]	+	[[Category: Grudnik P]]
-	[[Category: Heddle, J]]	+	[[Category: Heddle J]]
-	[[Category: Kumar, M]]	+	[[Category: Kumar M]]
-	[[Category: Wilk, P]]	+	[[Category: Wilk P]]
-	~~[[Category: Engineered protein]]~~	+
-	~~[[Category: Metal binding]]~~	+
-	~~[[Category: Metal binding protein~~]]	+

OCA at 05:05, 10 August 2022

2022-08-10T05:05:17Z

←Older revision		Revision as of 05:05, 10 August 2022
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	==Crystal structure of thermotoga maritima E65K Ferritin==		==Crystal structure of thermotoga maritima E65K Ferritin==
-	<StructureSection load='6txk' size='340' side='right'caption='[[6txk]]' scene=''>	+	<StructureSection load='6txk' size='340' side='right'caption='[[6txk]], [[Resolution\|resolution]] 2.36Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXK FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6txk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Thema Thema]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXK FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txk OCA], [https://pdbe.org/6txk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txk RCSB], [https://www.ebi.ac.uk/pdbsum/6txk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txk ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LFA:EICOSANE'>LFA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TM_1128 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 THEMA])</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Bacterial_non-heme_ferritin Bacterial non-heme ferritin], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.2 1.16.3.2] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txk OCA], [https://pdbe.org/6txk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txk RCSB], [https://www.ebi.ac.uk/pdbsum/6txk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txk ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[[https://www.uniprot.org/uniprot/Q9X0L2_THEMA Q9X0L2_THEMA]] Iron storage protein (By similarity).[RuleBase:RU361145]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cage forming proteins have numerous potential applications in biomedicine and biotechnology, where the iron storage ferritin is a widely used example. However, controlling ferritin cage assembly/disassembly remains challenging, typically requiring extreme conditions incompatible with many desirable cargoes, particularly for more fragile biopharmaceuticals. Recently, a ferritin from the hyperthermophile bacterium Thermotoga maritima (TmFtn) has been shown to have reversible assembly under mild conditions, offering greater potential biocompatibility in terms of cargo access and encapsulation. Like Archeoglobus fulgidus ferritin (AfFtn), TmFtn forms 24mer cages mediated by metal ions (Mg2+). We have solved the crystal structure of the wild type TmFtn and several mutants displaying different assembly/disassembly properties. These data combined with other biophysical studies allow us to suggest candidate interfacial amino acids crucial in controlling assembly. This work deepens our understanding of how these ferritin complexes assemble and is a useful step towards production of triggerable ferritins in which these properties can be finely designed and controlled.
		+
		+	A single residue can modulate nanocage assembly in salt dependent ferritin.,Kumar M, Markiewicz-Mizera J, Janna Olmos JD, Wilk P, Grudnik P, Biela AP, Jemiola-Rzeminska M, Gorecki A, Chakraborti S, Heddle JG Nanoscale. 2021 Jul 15;13(27):11932-11942. doi: 10.1039/d1nr01632f. PMID:34195748<ref>PMID:34195748</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6txk" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacterial non-heme ferritin]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chakraborti S]]	+	[[Category: Thema]]
-	[[Category: Grudnik P]]	+	[[Category: Chakraborti, S]]
-	[[Category: Heddle J]]	+	[[Category: Grudnik, P]]
-	[[Category: Kumar M]]	+	[[Category: Heddle, J]]
-	[[Category: Wilk P]]	+	[[Category: Kumar, M]]
		+	[[Category: Wilk, P]]
		+	[[Category: Engineered protein]]
		+	[[Category: Metal binding]]
		+	[[Category: Metal binding protein]]

OCA at 10:30, 28 July 2021

2021-07-28T10:30:51Z

←Older revision		Revision as of 10:30, 28 July 2021
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6txk ~~is ON HOLD until Paper Publication~~	+	==Crystal structure of thermotoga maritima E65K Ferritin==
-		+	<StructureSection load='6txk' size='340' side='right'caption='[[6txk]]' scene=''>
-	~~Authors~~: ~~Wilk, P~~., ~~Grudnik~~, P., ~~Kumar, M~~., ~~Heddle, J~~., ~~Chakraborti, S~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TXK FirstGlance]. <br>
-	~~Description: Crystal structure of thermotoga maritima E65K Ferritin~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6txk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txk OCA], [https://pdbe.org/6txk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6txk RCSB], [https://www.ebi.ac.uk/pdbsum/6txk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6txk ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Chakraborti, S]]	+	__TOC__
-	[[Category: ~~Wilk,~~ P]]	+	</StructureSection>
-	[[Category: ~~Grudnik, P~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Heddle, J~~]]	+	[[Category: Chakraborti S]]
-	[[Category: ~~Kumar, M~~]]	+	[[Category: Grudnik P]]
		+	[[Category: Heddle J]]
		+	[[Category: Kumar M]]
		+	[[Category: Wilk P]]

OCA at 06:27, 22 July 2020

2020-07-22T06:27:14Z

←Older revision		Revision as of 06:27, 22 July 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6txk is ON HOLD	+	The entry 6txk is ON HOLD until Paper Publication

	Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S.		Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S.
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	Description: Crystal structure of thermotoga maritima E65K Ferritin		Description: Crystal structure of thermotoga maritima E65K Ferritin
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Chakraborti, S]]
	[[Category: Wilk, P]]		[[Category: Wilk, P]]
	[[Category: Grudnik, P]]		[[Category: Grudnik, P]]
-	[[Category: Kumar, M]]
-	[[Category: Chakraborti, S]]
	[[Category: Heddle, J]]		[[Category: Heddle, J]]
		+	[[Category: Kumar, M]]

OCA: Protected "6txk" [edit=sysop:move=sysop]

2020-01-22T14:05:42Z

Protected "6txk" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:05, 22 January 2020

OCA: New page: '''Unreleased structure''' The entry 6txk is ON HOLD Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S. Description: Crystal structure of thermotoga maritima E65K F...

2020-01-22T14:05:40Z

New page: '''Unreleased structure''' The entry 6txk is ON HOLD Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S. Description: Crystal structure of thermotoga maritima E65K F...

New page

'''Unreleased structure'''

The entry 6txk is ON HOLD

Authors: Wilk, P., Grudnik, P., Kumar, M., Heddle, J., Chakraborti, S.

Description: Crystal structure of thermotoga maritima E65K Ferritin
[[Category: Unreleased Structures]]
[[Category: Wilk, P]]
[[Category: Grudnik, P]]
[[Category: Kumar, M]]
[[Category: Chakraborti, S]]
[[Category: Heddle, J]]