6tyl - Revision history

OCA at 07:40, 11 October 2023

2023-10-11T07:40:19Z

←Older revision		Revision as of 07:40, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6tyl' size='340' side='right'caption='[[6tyl]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6tyl' size='340' side='right'caption='[[6tyl]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tyl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~] and [https://en.wikipedia.org/wiki/~~Camelus_glama Camelus glama~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tyl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TYL FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=SEP:PHOSPHOSERINE'>SEP</scene~~>, ~~<scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.3Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Ric8a, rCG_48458 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=10116 Buffalo rat]), Gnai1, Gnai-1 ([https~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tyl OCA], [https://pdbe.org/6tyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tyl RCSB], [https://www.ebi.ac.uk/pdbsum/6tyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tyl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tyl OCA], [https://pdbe.org/6tyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tyl RCSB], [https://www.ebi.ac.uk/pdbsum/6tyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tyl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/~~GNAI1_RAT GNAI1_RAT~~]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>	+	[https://www.uniprot.org/uniprot/B1H241_RAT B1H241_RAT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 26:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat]]~~	+	[[Category: Lama glama]]
-	~~[[Category: Camelus~~ glama]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: McClelland, L]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Mou~~, T C~~]]	+	[[Category: McClelland L]]
-	[[Category: Sprang~~, S R~~]]	+	[[Category: Mou TC]]
-	[[Category: Yates-Hansen, C]]	+	[[Category: Sprang SR]]
-	~~[[Category: G protein]]~~	+	[[Category: Yates-Hansen C]]
-	~~[[Category: Gef]]~~	+
-	~~[[Category: Ric-8a]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 07:10, 16 March 2022

2022-03-16T07:10:35Z

←Older revision		Revision as of 07:10, 16 March 2022
Line 3:		Line 3:
	<StructureSection load='6tyl' size='340' side='right'caption='[[6tyl]], [[Resolution\|resolution]] 3.30Å' scene=''>		<StructureSection load='6tyl' size='340' side='right'caption='[[6tyl]], [[Resolution\|resolution]] 3.30Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6tyl]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TYL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6TYL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6tyl]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [https://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TYL FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tyl OCA], [~~http~~://pdbe.org/6tyl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6tyl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6tyl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6tyl ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Ric8a, rCG_48458 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), Gnai1, Gnai-1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tyl OCA], [https://pdbe.org/6tyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tyl RCSB], [https://www.ebi.ac.uk/pdbsum/6tyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tyl ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>	+	[[https://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 18:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 6tyl" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 6tyl" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[GTP-binding protein 3D structures\|GTP-binding protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Camelus glama]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: McClelland, L]]		[[Category: McClelland, L]]

OCA at 07:28, 11 March 2020

2020-03-11T07:28:28Z

←Older revision		Revision as of 07:28, 11 March 2020
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6tyl is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of mammalian Ric-8A:Galpha(i):nanobody complex==
		+	<StructureSection load='6tyl' size='340' side='right'caption='[[6tyl]], [[Resolution\|resolution]] 3.30Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6tyl]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TYL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TYL FirstGlance]. <br>
		+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tyl OCA], [http://pdbe.org/6tyl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tyl RCSB], [http://www.ebi.ac.uk/pdbsum/6tyl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tyl ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GNAI1_RAT GNAI1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:16870394</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G protein alpha subunits (Galpha) and serves as an essential Galpha chaperone. Mechanisms by which Ric-8A catalyzes these activities, which are stimulated by Casein Kinase II phosphorylation, are unknown. We report the structure of the nanobody-stabilized complex of nucleotide-free Galpha bound to phosphorylated Ric-8A at near atomic resolution by cryo-electron microscopy and X-ray crystallography. The mechanism of Ric-8A GEF activity differs considerably from that employed by G protein-coupled receptors at the plasma membrane. Ric-8A engages a specific conformation of Galpha at multiple interfaces to form a complex that is stabilized by phosphorylation within a Ric-8A segment that connects two Galpha binding sites. The C-terminus of Galpha is ejected from its beta sheet core, thereby dismantling the GDP binding site. Ric-8A binds to the exposed Galpha beta sheet and switch II to stabilize the nucleotide-free state of Galpha.

-	~~Authors~~:	+	Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Galphai1.,McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR Nat Commun. 2020 Feb 26;11(1):1077. doi: 10.1038/s41467-020-14943-4. PMID:32103024<ref>PMID:32103024</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6tyl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: McClelland, L]]
		+	[[Category: Mou, T C]]
		+	[[Category: Sprang, S R]]
		+	[[Category: Yates-Hansen, C]]
		+	[[Category: G protein]]
		+	[[Category: Gef]]
		+	[[Category: Ric-8a]]
		+	[[Category: Signaling protein]]

OCA: Protected "6tyl" [edit=sysop:move=sysop]

2019-08-21T04:23:04Z

Protected "6tyl" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:23, 21 August 2019

OCA: New page: '''Unreleased structure''' The entry 6tyl is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2019-08-21T04:23:02Z

New page: '''Unreleased structure''' The entry 6tyl is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6tyl is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]