6u3g - Revision history

OCA at 15:21, 29 November 2023

2023-11-29T15:21:35Z

←Older revision		Revision as of 15:21, 29 November 2023
Line 3:		Line 3:
	<SX load='6u3g' size='340' side='right' viewer='molstar' caption='[[6u3g]], [[Resolution\|resolution]] 53.00Å' scene=''>		<SX load='6u3g' size='340' side='right' viewer='molstar' caption='[[6u3g]], [[Resolution\|resolution]] 53.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u3g]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3G OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6U3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U3G FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=4IP:INOSITOL-(1~~,~~3,4,5)-TETRAKISPHOSPHATE'>4IP</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 53Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~CYTH3~~, ~~ARNO3~~, ~~GRP1~~, ~~PSCD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=~~5~~&id=9606 HUMAN]~~)</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3g OCA], [~~http~~://pdbe.org/6u3g PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6u3g RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6u3g PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3g OCA], [https://pdbe.org/6u3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u3g RCSB], [https://www.ebi.ac.uk/pdbsum/6u3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CYH3_HUMAN CYH3_HUMAN]] Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP.	+	[https://www.uniprot.org/uniprot/CYH3_HUMAN CYH3_HUMAN] Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 23:
	__TOC__		__TOC__
	</SX>		</SX>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Das, S]]	+	[[Category: Das S]]
-	[[Category: Lambright~~, D G]]~~	+	[[Category: Lambright DG]]
-	~~[[Category: Arf gef]]~~	+
-	~~[[Category: Endocytosis]]~~	+
-	~~[[Category: Ph domain]]~~	+
-	~~[[Category: Phosphoinositide binding]]~~	+
-	~~[[Category: Sec7 domain~~]]	+

OCA at 06:39, 11 April 2020

2020-04-11T06:39:05Z

←Older revision		Revision as of 06:39, 11 April 2020
Line 3:		Line 3:
	<SX load='6u3g' size='340' side='right' viewer='molstar' caption='[[6u3g]], [[Resolution\|resolution]] 53.00Å' scene=''>		<SX load='6u3g' size='340' side='right' viewer='molstar' caption='[[6u3g]], [[Resolution\|resolution]] 53.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3G OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6U3G FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U3G FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr>
	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYTH3, ARNO3, GRP1, PSCD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>		<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYTH3, ARNO3, GRP1, PSCD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3g OCA], [http://pdbe.org/6u3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3g RCSB], [http://www.ebi.ac.uk/pdbsum/6u3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3g ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3g OCA], [http://pdbe.org/6u3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3g RCSB], [http://www.ebi.ac.uk/pdbsum/6u3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3g ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 01:06, 7 March 2020

2020-03-07T01:06:46Z

←Older revision		Revision as of 01:06, 7 March 2020
Line 1:		Line 1:

	==Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)==		==Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)==
-	<~~StructureSection~~ load='6u3g' size='340' side='right'caption='[[6u3g]], [[Resolution\|resolution]] 53.00Å' scene=''>	+	<SX load='6u3g' size='340' side='right' viewer='molstar' caption='[[6u3g]], [[Resolution\|resolution]] 53.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6u3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U3G FirstGlance]. <br>		<table><tr><td colspan='2'>[[6u3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U3G FirstGlance]. <br>
Line 22:		Line 22:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Human]]		[[Category: Human]]
	[[Category: Large Structures]]		[[Category: Large Structures]]

OCA at 08:16, 23 October 2019

2019-10-23T08:16:31Z

←Older revision		Revision as of 08:16, 23 October 2019
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 6u3g is ~~ON HOLD~~	+	==Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)==
		+	<StructureSection load='6u3g' size='340' side='right'caption='[[6u3g]], [[Resolution\|resolution]] 53.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[6u3g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U3G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U3G FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4IP:INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE'>4IP</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CYTH3, ARNO3, GRP1, PSCD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u3g OCA], [http://pdbe.org/6u3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u3g RCSB], [http://www.ebi.ac.uk/pdbsum/6u3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u3g ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CYH3_HUMAN CYH3_HUMAN]] Promotes guanine-nucleotide exchange on ARF1. Promotes the activation of ARF through replacement of GDP with GTP.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Membrane dynamic processes require Arf GTPase activation by guanine nucleotide exchange factors (GEFs) with a Sec7 domain. Cytohesin family Arf GEFs function in signaling and cell migration through Arf GTPase activation on the plasma membrane and endosomes. In this study, the structural organization of two cytohesins (Grp1 and ARNO) was investigated in solution by size exclusion-small angle X-ray scattering and negative stain-electron microscopy and on membranes by dynamic light scattering, hydrogen-deuterium exchange-mass spectrometry and guanosine diphosphate (GDP)/guanosine triphosphate (GTP) exchange assays. The results suggest that cytohesins form elongated dimers with a central coiled coil and membrane-binding pleckstrin-homology (PH) domains at opposite ends. The dimers display significant conformational heterogeneity, with a preference for compact to intermediate conformations. Phosphoinositide-dependent membrane recruitment is mediated by one PH domain at a time and alters the conformational dynamics to prime allosteric activation by Arf-GTP. A structural model for membrane targeting and allosteric activation of full-length cytohesin dimers is discussed.

-	~~Authors:~~ Das, S., Lambright, D.G.	+	Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.,Das S, Malaby AW, Nawrotek A, Zhang W, Zeghouf M, Maslen S, Skehel M, Chakravarthy S, Irving TC, Bilsel O, Cherfils J, Lambright DG Structure. 2019 Oct 5. pii: S0969-2126(19)30313-2. doi:, 10.1016/j.str.2019.09.007. PMID:31601460<ref>PMID:31601460</ref>

-	~~Description: Best fitting antiparallel model for Volume 2~~ of ~~truncated dimeric Cytohesin~~-~~3 (Grp1; amino acids 14~~-~~399)~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased~~ Structures]]	+	</div>
		+	<div class="pdbe-citations 6u3g" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Das, S]]		[[Category: Das, S]]
-	[[Category: Lambright, D.G]]	+	[[Category: Lambright, D G]]
		+	[[Category: Arf gef]]
		+	[[Category: Endocytosis]]
		+	[[Category: Ph domain]]
		+	[[Category: Phosphoinositide binding]]
		+	[[Category: Sec7 domain]]

OCA: Protected "6u3g" [edit=sysop:move=sysop]

2019-08-28T14:06:29Z

Protected "6u3g" [edit=sysop:move=sysop]

←Older revision

Revision as of 14:06, 28 August 2019

OCA: New page: '''Unreleased structure''' The entry 6u3g is ON HOLD Authors: Das, S., Lambright, D.G. Description: Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1;...

2019-08-28T14:06:28Z

New page: '''Unreleased structure''' The entry 6u3g is ON HOLD Authors: Das, S., Lambright, D.G. Description: Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1;...

New page

'''Unreleased structure'''

The entry 6u3g is ON HOLD

Authors: Das, S., Lambright, D.G.

Description: Best fitting antiparallel model for Volume 2 of truncated dimeric Cytohesin-3 (Grp1; amino acids 14-399)
[[Category: Unreleased Structures]]
[[Category: Das, S]]
[[Category: Lambright, D.G]]