6u5a - Revision history

OCA at 07:44, 11 October 2023

2023-10-11T07:44:24Z

←Older revision		Revision as of 07:44, 11 October 2023
Line 3:		Line 3:
	<StructureSection load='6u5a' size='340' side='right'caption='[[6u5a]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6u5a' size='340' side='right'caption='[[6u5a]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u5a]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5A OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6U5A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u5a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U5A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PWY:(6-methoxynaphthalen-2-yl)acetic+acid'>PWY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.65Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6u5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5a OCA], [~~http~~://pdbe.org/6u5a PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6u5a RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6u5a PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5a ProSAT]</span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PWY:(6-methoxynaphthalen-2-yl)acetic+acid'>PWY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5a OCA], [https://pdbe.org/6u5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u5a RCSB], [https://www.ebi.ac.uk/pdbsum/6u5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5a ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ALBU_HORSE ALBU_HORSE]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 25:		Line 28:
	[[Category: Equus caballus]]		[[Category: Equus caballus]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Structural genomic]]~~	+	[[Category: Cymborowski MT]]
-	[[Category: Cymborowski~~, M T~~]]	+	[[Category: Czub MP]]
-	[[Category: Czub~~, M P~~]]	+	[[Category: Handing KB]]
-	[[Category: Handing~~, K B~~]]	+	[[Category: Joachimiak A]]
-	[[Category: Joachimiak, A]]	+	[[Category: Minor W]]
-	[[Category: Minor, W]]	+	[[Category: Satchell KJ]]
-	[[Category: Satchell~~, K J~~]]	+	[[Category: Shabalin IG]]
-	[[Category: Shabalin~~, I G~~]]	+	[[Category: Venkataramany BS]]
-	[[Category: Venkataramany~~, B S]]~~	+
-	~~[[Category: 6-mna]]~~	+
-	~~[[Category: Albumin]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Esa]]~~	+
-	~~[[Category: Nabumetone]]~~	+
-	~~[[Category: Nsaid]]~~	+
-	~~[[Category: Sa]]~~	+
-	~~[[Category: Transport protein~~]]	+

OCA at 11:36, 22 July 2020

2020-07-22T11:36:14Z

←Older revision		Revision as of 11:36, 22 July 2020
Line 3:		Line 3:
	<StructureSection load='6u5a' size='340' side='right'caption='[[6u5a]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='6u5a' size='340' side='right'caption='[[6u5a]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6u5a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5A OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6U5A FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u5a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5A OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6U5A FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PWY:(6-methoxynaphthalen-2-yl)acetic+acid'>PWY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PWY:(6-methoxynaphthalen-2-yl)acetic+acid'>PWY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6u5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5a OCA], [http://pdbe.org/6u5a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5a RCSB], [http://www.ebi.ac.uk/pdbsum/6u5a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5a ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6u5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5a OCA], [http://pdbe.org/6u5a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5a RCSB], [http://www.ebi.ac.uk/pdbsum/6u5a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5a ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Every day, hundreds of millions of people worldwide take nonsteroidal anti-inflammatory drugs (NSAIDs), often in conjunction with multiple other medications. In the bloodstream, NSAIDs are mostly bound to serum albumin (SA). We report the crystal structures of equine serum albumin complexed with four NSAIDs (ibuprofen, ketoprofen, etodolac, and nabumetone) and the active metabolite of nabumetone (6-methoxy-2-naphthylacetic acid, 6-MNA). These compounds bind to seven drug-binding sites on SA. These sites are generally well-conserved between equine and human SAs, but ibuprofen binds to both SAs in two drug-binding sites, only one of which is common. We also compare the binding of ketoprofen by equine SA to binding of it by bovine and leporine SAs. Our comparative analysis of known SA complexes with FDA-approved drugs clearly shows that multiple medications compete for the same binding sites, indicating possibilities for undesirable physiological effects caused by drug-drug displacement or competition with common metabolites. We discuss the consequences of NSAID binding to SA in a broader scientific and medical context, particularly regarding achieving desired therapeutic effects based on an individual's drug regimen.
		+
		+	Albumin-Based Transport of Nonsteroidal Anti-Inflammatory Drugs in Mammalian Blood Plasma.,Czub MP, Handing KB, Venkataramany BS, Cooper DR, Shabalin IG, Minor W J Med Chem. 2020 Jul 9;63(13):6847-6862. doi: 10.1021/acs.jmedchem.0c00225. Epub , 2020 Jun 17. PMID:32469516<ref>PMID:32469516</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6u5a" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Albumin 3D structures\|Albumin 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA: Protected "6u5a" [edit=sysop:move=sysop]

2019-12-18T13:17:29Z

Protected "6u5a" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:17, 18 December 2019

OCA: New page: ==Crystal structure of Equine Serum Albumin complex with 6-MNA== =...

2019-12-18T13:17:27Z

New page: ==Crystal structure of Equine Serum Albumin complex with 6-MNA== <StructureSection load='6u5a' size='340' side='right'caption='6u5a, resolution 2.65Å' scene=''> =...

New page

==Crystal structure of Equine Serum Albumin complex with 6-MNA==
<StructureSection load='6u5a' size='340' side='right'caption='[[6u5a]], [[Resolution|resolution]] 2.65Å' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6u5a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U5A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U5A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PWY:(6-methoxynaphthalen-2-yl)acetic+acid'>PWY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u5a OCA], [http://pdbe.org/6u5a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u5a RCSB], [http://www.ebi.ac.uk/pdbsum/6u5a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u5a ProSAT]</span></td></tr>
</table>
__TOC__
</StructureSection>
[[Category: Equus caballus]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Cymborowski, M T]]
[[Category: Czub, M P]]
[[Category: Handing, K B]]
[[Category: Joachimiak, A]]
[[Category: Minor, W]]
[[Category: Satchell, K J]]
[[Category: Shabalin, I G]]
[[Category: Venkataramany, B S]]
[[Category: 6-mna]]
[[Category: Albumin]]
[[Category: Csgid]]
[[Category: Esa]]
[[Category: Nabumetone]]
[[Category: Nsaid]]
[[Category: Sa]]
[[Category: Transport protein]]