OCA at 07:45, 11 October 2023

2023-10-11T07:45:05Z

←Older revision		Revision as of 07:45, 11 October 2023
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-	====	+	==Crystal structure of a vaccine-elicited anti-HIV-1 rhesus macaque antibody DH846==
-	<StructureSection load='6u6o' size='340' side='right'caption='[[6u6o]]' scene=''>	+	<StructureSection load='6u6o' size='340' side='right'caption='[[6u6o]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6u6o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U6O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U6O FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u6o OCA], [https://pdbe.org/6u6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u6o RCSB], [https://www.ebi.ac.uk/pdbsum/6u6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u6o ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.806Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u6o OCA], [https://pdbe.org/6u6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u6o RCSB], [https://www.ebi.ac.uk/pdbsum/6u6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u6o ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A primary goal of HIV-1 vaccine development is the consistent elicitation of protective, neutralizing antibodies. While highly similar neutralizing antibodies (nAbs) have been isolated from multiple HIV-infected individuals, it is unclear whether vaccination can consistently elicit highly similar nAbs in genetically diverse primates. Here, we show in three outbred rhesus macaques that immunization with Env elicits a genotypically and phenotypically conserved nAb response. From these vaccinated macaques, we isolated four antibody lineages that had commonalities in immunoglobulin variable, diversity, and joining gene segment usage. Atomic-level structures of the antigen binding fragments of the two most similar antibodies showed nearly identical paratopes. The Env binding modes of each of the four vaccine-induced nAbs were distinct from previously known monoclonal HIV-1 neutralizing antibodies, but were nearly identical to each other. The similarities of these antibodies show that the immune system in outbred primates can respond to HIV-1 Env vaccination with a similar structural and genotypic solution for recognizing a particular neutralizing epitope. These results support rational vaccine design for HIV-1 that aims to reproducibly elicit, in genetically diverse primates, nAbs with specific paratope structures capable of binding conserved epitopes.
		+
		+	Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates.,Cai F, Chen WH, Wu W, Jones JA, Choe M, Gohain N, Shen X, LaBranche C, Eaton A, Sutherland L, Lee EM, Hernandez GE, Wu NR, Scearce R, Seaman MS, Moody MA, Santra S, Wiehe K, Tomaras GD, Wagh K, Korber B, Bonsignori M, Montefiori DC, Haynes BF, de Val N, Joyce MG, Saunders KO PLoS Pathog. 2021 Jun 4;17(6):e1009624. doi: 10.1371/journal.ppat.1009624. , eCollection 2021 Jun. PMID:34086838<ref>PMID:34086838</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6u6o" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Z-~~disk~~]]	+	[[Category: Macaca mulatta]]
		+	[[Category: Chen W-H]]
		+	[[Category: Choe M]]
		+	[[Category: Joyce MG]]
		+	[[Category: Saunders KO]]

OCA at 06:37, 24 March 2021

2021-03-24T06:37:24Z

←Older revision		Revision as of 06:37, 24 March 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6u6o ~~is ON HOLD until Paper Publication~~	+	====
-		+	<StructureSection load='6u6o' size='340' side='right'caption='[[6u6o]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u6o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u6o OCA], [https://pdbe.org/6u6o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u6o RCSB], [https://www.ebi.ac.uk/pdbsum/6u6o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u6o ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Z-disk]]

OCA: Protected "6u6o" [edit=sysop:move=sysop]

2019-10-02T08:18:17Z

Protected "6u6o" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:18, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6u6o is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

2019-10-02T08:18:15Z

New page: '''Unreleased structure''' The entry 6u6o is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6u6o is ON HOLD until Paper Publication

Authors:

Description:
[[Category: Unreleased Structures]]

6u6o - Revision history

OCA at 07:45, 11 October 2023

OCA at 06:37, 24 March 2021

OCA: Protected "6u6o" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6u6o is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures