6ufy - Revision history

OCA at 07:50, 11 October 2023

2023-10-11T07:50:29Z

←Older revision		Revision as of 07:50, 11 October 2023
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	<StructureSection load='6ufy' size='340' side='right'caption='[[6ufy]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='6ufy' size='340' side='right'caption='[[6ufy]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ufy]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bactn Bactn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFY OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6UFY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ufy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UFY FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BT_2086 (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=226186 BACTN])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.71Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=6ufy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufy OCA], [~~http~~://pdbe.org/6ufy PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6ufy RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6ufy PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufy ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ufy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufy OCA], [https://pdbe.org/6ufy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ufy RCSB], [https://www.ebi.ac.uk/pdbsum/6ufy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufy ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8A600_BACTN Q8A600_BACTN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bactn~~]]	+	[[Category: Bacteroides thetaiotaomicron VPI-5482]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Seegar~~, T C.M]]~~	+	[[Category: Seegar TCM]]
-	~~[[Category: Bile salt hydrolase]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 10:33, 26 February 2020

2020-02-26T10:33:37Z

←Older revision		Revision as of 10:33, 26 February 2020
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	<StructureSection load='6ufy' size='340' side='right'caption='[[6ufy]], [[Resolution\|resolution]] 2.71Å' scene=''>		<StructureSection load='6ufy' size='340' side='right'caption='[[6ufy]], [[Resolution\|resolution]] 2.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[6ufy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UFY FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ufy]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bactn Bactn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UFY FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ufy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufy OCA], [http://pdbe.org/6ufy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ufy RCSB], [http://www.ebi.ac.uk/pdbsum/6ufy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufy ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BT_2086 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=226186 BACTN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ufy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufy OCA], [http://pdbe.org/6ufy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ufy RCSB], [http://www.ebi.ac.uk/pdbsum/6ufy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufy ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bile salt hydrolase (BSH) enzymes are widely expressed by human gut bacteria and catalyze the gateway reaction leading to secondary bile acid formation. Bile acids regulate key metabolic and immune processes by binding to host receptors. There is an unmet need for a potent tool to inhibit BSHs across all gut bacteria to study the effects of bile acids on host physiology. Here, we report the development of a covalent pan-inhibitor of gut bacterial BSHs. From a rationally designed candidate library, we identified a lead compound bearing an alpha-fluoromethyl ketone warhead that modifies BSH at the catalytic cysteine residue. This inhibitor abolished BSH activity in conventional mouse feces. Mice gavaged with a single dose of this compound displayed decreased BSH activity and decreased deconjugated bile acid levels in feces. Our studies demonstrate the potential of a covalent BSH inhibitor to modulate bile acid composition in vivo.
		+
		+	Development of a covalent inhibitor of gut bacterial bile salt hydrolases.,Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD, Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin AS Nat Chem Biol. 2020 Mar;16(3):318-326. doi: 10.1038/s41589-020-0467-3. Epub 2020 , Feb 10. PMID:32042200<ref>PMID:32042200</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ufy" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bactn]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Seegar, T C.M]]		[[Category: Seegar, T C.M]]
	[[Category: Bile salt hydrolase]]		[[Category: Bile salt hydrolase]]
	[[Category: Hydrolase]]		[[Category: Hydrolase]]

OCA at 06:42, 19 February 2020

2020-02-19T06:42:42Z

←Older revision		Revision as of 06:42, 19 February 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6ufy ~~is ON HOLD until Paper Publication~~	+	==B. theta Bile Salt Hydrolase==
-		+	<StructureSection load='6ufy' size='340' side='right'caption='[[6ufy]], [[Resolution\|resolution]] 2.71Å' scene=''>
-	~~Authors~~: ~~Seegar, T~~.C.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6ufy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UFY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UFY FirstGlance]. <br>
-	~~Description~~: B. ~~theta Bile Salt Hydrolase~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ufy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ufy OCA], [http://pdbe.org/6ufy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ufy RCSB], [http://www.ebi.ac.uk/pdbsum/6ufy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ufy ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
-	[[Category: Seegar, T.C.M]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Seegar, T C.M]]
		+	[[Category: Bile salt hydrolase]]
		+	[[Category: Hydrolase]]

OCA at 06:05, 8 January 2020

2020-01-08T06:05:36Z

←Older revision		Revision as of 06:05, 8 January 2020
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6ufy is ON HOLD	+	The entry 6ufy is ON HOLD until Paper Publication

	Authors: Seegar, T.C.M.		Authors: Seegar, T.C.M.

OCA: Protected "6ufy" [edit=sysop:move=sysop]

2019-10-02T08:47:52Z

Protected "6ufy" [edit=sysop:move=sysop]

←Older revision

Revision as of 08:47, 2 October 2019

OCA: New page: '''Unreleased structure''' The entry 6ufy is ON HOLD Authors: Seegar, T.C.M. Description: B. theta Bile Salt Hydrolase Category: Unreleased Structures Category: Seegar, T.C.M

2019-10-02T08:47:51Z

New page: '''Unreleased structure''' The entry 6ufy is ON HOLD Authors: Seegar, T.C.M. Description: B. theta Bile Salt Hydrolase Category: Unreleased Structures Category: Seegar, T.C.M

New page

'''Unreleased structure'''

The entry 6ufy is ON HOLD

Authors: Seegar, T.C.M.

Description: B. theta Bile Salt Hydrolase
[[Category: Unreleased Structures]]
[[Category: Seegar, T.C.M]]