OCA at 07:54, 11 October 2023

2023-10-11T07:54:08Z

←Older revision		Revision as of 07:54, 11 October 2023
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-	====	+	==BRD2-BD2 in complex with the cyclic peptide 4.2_3==
-	<StructureSection load='6ult' size='340' side='right'caption='[[6ult]]' scene=''>	+	<StructureSection load='6ult' size='340' side='right'caption='[[6ult]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6ult]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ULT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ULT FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ult FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ult OCA], [https://pdbe.org/6ult PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ult RCSB], [https://www.ebi.ac.uk/pdbsum/6ult PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ult ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ult FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ult OCA], [https://pdbe.org/6ult PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ult RCSB], [https://www.ebi.ac.uk/pdbsum/6ult PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ult ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cyclic peptide library screening technologies show immense promise for identifying drug leads and chemical probes for challenging targets. However, the structural and functional diversity encoded within such libraries is largely undefined. We have systematically profiled the affinity, selectivity, and structural features of library-derived cyclic peptides selected to recognize three closely related targets: the acetyllysine-binding bromodomain proteins BRD2, -3, and -4. We report affinities as low as 100 pM and specificities of up to 10(6)-fold. Crystal structures of 13 peptide-bromodomain complexes reveal remarkable diversity in both structure and binding mode, including both alpha-helical and beta-sheet structures as well as bivalent binding modes. The peptides can also exhibit a high degree of structural preorganization. Our data demonstrate the enormous potential within these libraries to provide diverse binding modes against a single target, which underpins their capacity to yield highly potent and selective ligands.
		+
		+	Cyclic peptides can engage a single binding pocket through highly divergent modes.,Patel K, Walport LJ, Walshe JL, Solomon PD, Low JKK, Tran DH, Mouradian KS, Silva APG, Wilkinson-White L, Norman A, Franck C, Matthews JM, Guss JM, Payne RJ, Passioura T, Suga H, Mackay JP Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26728-26738. doi: , 10.1073/pnas.2003086117. Epub 2020 Oct 12. PMID:33046654<ref>PMID:33046654</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6ult" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Z-disk~~]]	+	[[Category: Synthetic construct]]
		+	[[Category: Mackay JP]]
		+	[[Category: Patel K]]
		+	[[Category: Walport LJ]]
		+	[[Category: Walshe JL]]

OCA at 06:38, 24 February 2021

2021-02-24T06:38:29Z

←Older revision		Revision as of 06:38, 24 February 2021
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-	'''Unreleased structure'''

-	~~The entry~~ 6ult ~~is ON HOLD~~	+	====
-		+	<StructureSection load='6ult' size='340' side='right'caption='[[6ult]]' scene=''>
-	~~Authors~~: ~~Patel, K~~.~~, Walshe, J~~.L.~~, Walport, L~~.J.~~, Mackay, J~~.P.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
-	~~Description~~: ~~BRD2-BD2 in complex with the cyclic peptide 4~~.~~2_3~~	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ult FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ult OCA], [https://pdbe.org/6ult PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ult RCSB], [https://www.ebi.ac.uk/pdbsum/6ult PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ult ProSAT]</span></td></tr>
-	[~~[Category~~: ~~Unreleased Structures]~~]	+	</table>
-	[~~[Category~~: ~~Mackay, J~~.P]]	+	__TOC__
-	[~~[Category~~: ~~Walport~~, L.J]]	+	</StructureSection>
-	[[Category: ~~Patel, K~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Walshe, J.L~~]]	+	[[Category: Z-disk]]

OCA: Protected "6ult" [edit=sysop:move=sysop]

2019-10-16T04:39:51Z

Protected "6ult" [edit=sysop:move=sysop]

←Older revision

Revision as of 04:39, 16 October 2019

OCA: New page: '''Unreleased structure''' The entry 6ult is ON HOLD Authors: Patel, K., Walshe, J.L., Walport, L.J., Mackay, J.P. Description: BRD2-BD2 in complex with the cyclic peptide 4.2_3 [[Cate...

2019-10-16T04:39:49Z

New page: '''Unreleased structure''' The entry 6ult is ON HOLD Authors: Patel, K., Walshe, J.L., Walport, L.J., Mackay, J.P. Description: BRD2-BD2 in complex with the cyclic peptide 4.2_3 [[Cate...

New page

'''Unreleased structure'''

The entry 6ult is ON HOLD

Authors: Patel, K., Walshe, J.L., Walport, L.J., Mackay, J.P.

Description: BRD2-BD2 in complex with the cyclic peptide 4.2_3
[[Category: Unreleased Structures]]
[[Category: Mackay, J.P]]
[[Category: Walport, L.J]]
[[Category: Patel, K]]
[[Category: Walshe, J.L]]

6ult - Revision history

OCA at 07:54, 11 October 2023

OCA at 06:38, 24 February 2021

OCA: Protected "6ult" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6ult is ON HOLD Authors: Patel, K., Walshe, J.L., Walport, L.J., Mackay, J.P. Description: BRD2-BD2 in complex with the cyclic peptide 4.2_3 [[Cate...