OCA at 08:28, 4 December 2019

2019-12-04T08:28:05Z

←Older revision		Revision as of 08:28, 4 December 2019
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-	'''Unreleased structure'''

-	~~The entry~~ 6uy1 is ~~ON HOLD~~	+	==Crystal structure of the Sth1 bromodomain from Saccharomyces cerevisiae at 2.2 Angstrom resolution==
-		+	<StructureSection load='6uy1' size='340' side='right'caption='[[6uy1]], [[Resolution\|resolution]] 2.21Å' scene=''>
-	~~Authors~~: ~~Stavropoulos~~, P., ~~Hoelz~~, A.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6uy1]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UY1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UY1 FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of the ~~Sth1 bromodomain~~ from ~~Saccharomyces cerevisiae at 2~~.~~2 Angstrom resolution~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[6mr4\|6mr4]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_helicase DNA helicase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.4.12 3.6.4.12] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uy1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uy1 OCA], [http://pdbe.org/6uy1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uy1 RCSB], [http://www.ebi.ac.uk/pdbsum/6uy1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uy1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/STH1_YEAST STH1_YEAST]] Catalytic component of the chromatin structure-remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is the essential ATPase of the complex. It is a DNA translocase capable of nucleosome remodeling. Required for full expression of early meiotic genes. Essential for mitotic growth and repression of CHA1 expression. Also involved in G2 phase control.<ref>PMID:10025404</ref> <ref>PMID:10320476</ref> <ref>PMID:10329629</ref> <ref>PMID:12072455</ref> <ref>PMID:12183366</ref> <ref>PMID:12697820</ref> <ref>PMID:8980231</ref> <ref>PMID:9799253</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: DNA helicase]]
		+	[[Category: Large Structures]]
		+	[[Category: Hoelz, A]]
	[[Category: Stavropoulos, P]]		[[Category: Stavropoulos, P]]
-	[[Category: ~~Hoelz, A~~]]	+	[[Category: Bromodomain]]
		+	[[Category: Nuclear protein]]
		+	[[Category: Sth1]]

OCA: Protected "6uy1" [edit=sysop:move=sysop]

2019-11-20T13:55:27Z

Protected "6uy1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:55, 20 November 2019

OCA: New page: '''Unreleased structure''' The entry 6uy1 is ON HOLD Authors: Stavropoulos, P., Hoelz, A. Description: Crystal structure of the Sth1 bromodomain from Saccharomyces cerevisiae at 2.2 An...

2019-11-20T13:55:25Z

New page: '''Unreleased structure''' The entry 6uy1 is ON HOLD Authors: Stavropoulos, P., Hoelz, A. Description: Crystal structure of the Sth1 bromodomain from Saccharomyces cerevisiae at 2.2 An...

New page

'''Unreleased structure'''

The entry 6uy1 is ON HOLD

Authors: Stavropoulos, P., Hoelz, A.

Description: Crystal structure of the Sth1 bromodomain from Saccharomyces cerevisiae at 2.2 Angstrom resolution
[[Category: Unreleased Structures]]
[[Category: Stavropoulos, P]]
[[Category: Hoelz, A]]

6uy1 - Revision history

OCA at 08:28, 4 December 2019

OCA: Protected "6uy1" [edit=sysop:move=sysop]

OCA: New page: '''Unreleased structure''' The entry 6uy1 is ON HOLD Authors: Stavropoulos, P., Hoelz, A. Description: Crystal structure of the Sth1 bromodomain from Saccharomyces cerevisiae at 2.2 An...