6uy3 - Revision history

OCA at 08:00, 11 October 2023

2023-10-11T08:00:35Z

←Older revision		Revision as of 08:00, 11 October 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[6uy3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae_mixed_library Camelidae mixed library]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UY3 FirstGlance]. <br>		<table><tr><td colspan='2'>[[6uy3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae_mixed_library Camelidae mixed library]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UY3 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~, ~~<scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"><~~div style~~='~~overflow~~: ~~auto; max-height~~: ~~3em;~~'>~~[[6uup\|6uup]]~~, ~~[[3f12\|3f12]]~~</~~div~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uy3 OCA], [https://pdbe.org/6uy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uy3 RCSB], [https://www.ebi.ac.uk/pdbsum/6uy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uy3 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uy3 OCA], [https://pdbe.org/6uy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uy3 RCSB], [https://www.ebi.ac.uk/pdbsum/6uy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uy3 ProSAT]</span></td></tr>
	</table>		</table>
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Monoclonal Antibodies 3D structures\|Monoclonal Antibodies 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	[[Category: Camelidae mixed library]]		[[Category: Camelidae mixed library]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kimberlin~~, C R~~]]	+	[[Category: Kimberlin CR]]
-	[[Category: Park, S]]	+	[[Category: Park S]]
-	~~[[Category: Antitumor protein]]~~	+
-	~~[[Category: Cd33]]~~	+
-	~~[[Category: Conditional antibody]]~~	+
-	~~[[Category: Conditional car]]~~	+
-	~~[[Category: Mtx~~]]	+

OCA at 16:52, 15 December 2021

2021-12-15T16:52:18Z

←Older revision		Revision as of 16:52, 15 December 2021
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	==Structure of anti-hCD33 conditional scFv with methotrexate==		==Structure of anti-hCD33 conditional scFv with methotrexate==
-	<StructureSection load='6uy3' size='340' side='right'caption='[[6uy3]]' scene=''>	+	<StructureSection load='6uy3' size='340' side='right'caption='[[6uy3]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UY3 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=6UY3 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[6uy3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae_mixed_library Camelidae mixed library]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6UY3 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=6uy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uy3 OCA], [~~http~~://pdbe.org/6uy3 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=6uy3 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/6uy3 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=6uy3 ProSAT]</span></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MTX:METHOTREXATE'>MTX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6uup\|6uup]], [[3f12\|3f12]]</div></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6uy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uy3 OCA], [https://pdbe.org/6uy3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6uy3 RCSB], [https://www.ebi.ac.uk/pdbsum/6uy3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6uy3 ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibody-based therapeutics have experienced a rapid growth in recent years and are now utilized in various modalities spanning from conventional antibodies, antibody-drug conjugates, bispecific antibodies to chimeric antigen receptor (CAR) T cells. Many next generation antibody therapeutics achieve enhanced potency but often increase the risk of adverse events. Antibody scaffolds capable of exhibiting inducible affinities could reduce the risk of adverse events by enabling a transient suspension of antibody activity. To demonstrate this, we develop conditionally activated, single-module CARs, in which tumor antigen recognition is directly modulated by an FDA-approved small molecule drug. The resulting CAR T cells demonstrate specific cytotoxicity of tumor cells comparable to that of traditional CARs, but the cytotoxicity is reversibly attenuated by the addition of the small molecule. The exogenous control of conditional CAR T cell activity allows continual modulation of therapeutic activity to improve the safety profile of CAR T cells across all disease indications.
		+
		+	Direct control of CAR T cells through small molecule-regulated antibodies.,Park S, Pascua E, Lindquist KC, Kimberlin C, Deng X, Mak YSL, Melton Z, Johnson TO, Lin R, Boldajipour B, Abraham RT, Pons J, Sasu BJ, Van Blarcom TJ, Chaparro-Riggers J Nat Commun. 2021 Jan 29;12(1):710. doi: 10.1038/s41467-020-20671-6. PMID:33514714<ref>PMID:33514714</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6uy3" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Camelidae mixed library]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kimberlin CR]]	+	[[Category: Kimberlin, C R]]
-	[[Category: Park S]]	+	[[Category: Park, S]]
		+	[[Category: Antitumor protein]]
		+	[[Category: Cd33]]
		+	[[Category: Conditional antibody]]
		+	[[Category: Conditional car]]
		+	[[Category: Mtx]]

OCA at 09:36, 18 November 2020

2020-11-18T09:36:31Z

←Older revision		Revision as of 09:36, 18 November 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6uy3 ~~is ON HOLD until Paper Publication~~	+	==Structure of anti-hCD33 conditional scFv with methotrexate==
-		+	<StructureSection load='6uy3' size='340' side='right'caption='[[6uy3]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UY3 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6UY3 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6uy3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uy3 OCA], [http://pdbe.org/6uy3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uy3 RCSB], [http://www.ebi.ac.uk/pdbsum/6uy3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uy3 ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Kimberlin CR]]
		+	[[Category: Park S]]

OCA at 06:33, 4 December 2019

2019-12-04T06:33:41Z

←Older revision		Revision as of 06:33, 4 December 2019
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 6uy3 is ON HOLD	+	The entry 6uy3 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "6uy3" [edit=sysop:move=sysop]

2019-11-20T13:55:38Z

Protected "6uy3" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:55, 20 November 2019

OCA: New page: '''Unreleased structure''' The entry 6uy3 is ON HOLD Authors: Description: Category: Unreleased Structures

2019-11-20T13:55:37Z

New page: '''Unreleased structure''' The entry 6uy3 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6uy3 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]