6v1n - Revision history

OCA at 16:59, 22 January 2020

2020-01-22T16:59:43Z

←Older revision		Revision as of 16:59, 22 January 2020
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/CSP1_STREE CSP1_STREE]] Acts as a pheromone, induces cells to develop competence for genetic transformation.		[[http://www.uniprot.org/uniprot/CSP1_STREE CSP1_STREE]] Acts as a pheromone, induces cells to develop competence for genetic transformation.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Streptococcus pneumoniae is an opportunistic human pathogen that utilizes the competence regulon, a quorum-sensing circuitry, to acquire antibiotic resistance genes and initiate its attack on the human host. Interception of the competence regulon can therefore be utilized to study S. pneumoniae cell-cell communication and behavioral changes, as well as attenuate S. pneumoniae infectivity. Herein we report the design and synthesis of cyclic dominant negative competence-stimulating peptide (dnCSP) analogs capable of intercepting the competence regulon in both S. pneumoniae specificity groups with activities at the low nanomolar range. Structural analysis of lead analogs provided important insights as to the molecular mechanism that drives CSP receptor binding and revealed that the pan-group cyclic CSPs exhibit a chimeric hydrophobic patch conformation that resembles the hydrophobic patches required for both ComD1 and ComD2 binding. Moreover, the lead cyclic dnCSP, CSP1-E1A-cyc(Dap6E10), was found to possess superior pharmacological properties, including improved resistance to enzymatic degradation, while remaining nontoxic. Lastly, CSP1-E1A-cyc(Dap6E10) was capable of attenuating mouse mortality during acute pneumonia caused by both group 1 and group 2 S. pneumoniae strains. This cyclic pan-group dnCSP is therefore a promising drug lead scaffold against S. pneumoniae infections that could be administered individually or utilized in combination therapy to augment the effects of current antimicrobial agents.
		+
		+	Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in Streptococcus pneumoniae.,Yang Y, Lin J, Harrington A, Cornilescu G, Lau GW, Tal-Gan Y Proc Natl Acad Sci U S A. 2020 Jan 8. pii: 1915812117. doi:, 10.1073/pnas.1915812117. PMID:31915298<ref>PMID:31915298</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 6v1n" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 07:42, 8 January 2020

2020-01-08T07:42:28Z

←Older revision		Revision as of 07:42, 8 January 2020
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-	'''Unreleased structure'''

-	~~The entry~~ 6v1n is ~~ON HOLD~~	+	==CSP1-E1A-cyc(Dap6E10)==
-		+	<StructureSection load='6v1n' size='340' side='right'caption='[[6v1n]], [[NMR_Ensembles_of_Models \| 20 NMR models]]' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[6v1n]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6V1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6V1N FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DPP:DIAMINOPROPANOIC+ACID'>DPP</scene></td></tr>
-	[[Category: ~~Unreleased~~ Structures]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6v1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6v1n OCA], [http://pdbe.org/6v1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6v1n RCSB], [http://www.ebi.ac.uk/pdbsum/6v1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6v1n ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CSP1_STREE CSP1_STREE]] Acts as a pheromone, induces cells to develop competence for genetic transformation.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Yang, Y]]
		+	[[Category: Biosynthetic protein]]
		+	[[Category: Modulator]]
		+	[[Category: Quorum sensing]]

OCA: Protected "6v1n" [edit=sysop:move=sysop]

2019-11-27T05:29:04Z

Protected "6v1n" [edit=sysop:move=sysop]

←Older revision

Revision as of 05:29, 27 November 2019

OCA: New page: '''Unreleased structure''' The entry 6v1n is ON HOLD Authors: Description: Category: Unreleased Structures

2019-11-27T05:29:02Z

New page: '''Unreleased structure''' The entry 6v1n is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 6v1n is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]